Cheng, Yung-Chi - Yale University - Biological & Biomedical Sciences

个人简介

The Cheng laboratory studies the action of antiviral drugs against HBV, HIV, EBV, and HCV, as well as the discovery of antivirals with unique mode of action against those viruses. PhD Brown University (1972)

研究领域

China; Drugs, Chinese Herbal; Hong Kong; Medicine, Chinese Traditional; Neoplasms by Histologic Type; Pharmacology

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities Uzuner H, Bauer R, Fan TP, Guo DA, Dias A, El-Nezami H, Efferth T, Williamson EM, Heinrich M, Robinson N, Hylands PJ, Hendry BM, Cheng YC, Xu Q.Traditional Chinese medicine research in the post-genomic era: good practice, priorities, challenges and opportunities. J Ethnopharmacol.(2012) Apr 10;140(3):458-68. PMCID: PMC22387462 Blocking HIV-1 entry by a gp120 surface binding inhibitor. Bioorg Med Chem Lett Tsou LK, Chen CH, Dutschman GE, Cheng YC, Hamilton AD.Blocking HIV-1 entry by a gp120 surface binding inhibitor. Bioorg Med Chem Lett. (2012) May 1;22(9):3358-61.PMCID: PMC3640310 Therapeutic development in targeting protein-protein interactions with synthetic topological mimetics Tsou LK, Cheng Y, Cheng YC. Therapeutic development in targeting protein-protein interactions with synthetic topological mimetics. Curr Opin Pharmacol. (2012) Aug;12(4):403-7. PMCID: PMC3660839 Antitumor agents 294. Novel E-ring-modified camptothecin-4ß-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents Ye D, Shi Q, Leung CH, Kim SW, Park SY, Gullen EA, Jiang ZL, Zhu H, Morris-Natschke SL, Cheng YC, Lee KH.Antitumor agents 294. Novel E-ring-modified camptothecin-4ß-anilino-4'-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents. Bioorg Med Chem. (2012) Jul 15;20(14):4489-94. PMCID: PMC3389137 Preclinical studies of the Chinese Herbal Medicine formulation PHY906 (KD018) as a potential adjunct to radiation therapy Rockwell S, Grove TA, Liu Y, Cheng YC, Higgins SA, Booth CJ. Preclinical studies of the Chinese Herbal Medicine formulation PHY906 (KD018) as a potential adjunct to radiation therapy. Int J Radiat Biol.( 2013) PMCID: PMC3660854. The journey of PHY906 as cancer adjuvant therapy Liu, S. H. & Cheng, Y. C. Old formula, new Rx: The journey of PHY906 as cancer adjuvant therapy. J Ethnopharmacol 140, 614-623, doi:10.1016/j.jep.2012.01.047 (2012).PMCID: PMC22326673 Zhou X, Chen LL, Xie RF, Lam W, Zhang ZJ, Jiang ZL, Cheng YC: Chemosynthesis pathway and bioactivities comparison of saponins in radix and flower of Panax notoginseng (Burk.) F.H. Chen. J Ethnopharmacol. 2017 Apr 6; 2016 Nov 9. PMID: 27838357 Chao J, Dai Y, Cheng HY, Lam W, Cheng YC, Li K, Peng WH, Pao LH, Hsieh MT, Qin XM, Lee MS: Improving the Concentrations of the Active Components in the Herbal Tea Ingredient, Uraria crinita: The Effect of Post-harvest Oven-drying Processing. Sci Rep. 2017 Jan 12; 2017 Jan 12. PMID: 28079108 Wang Y, Lam W, Chen SR, Guan FL, Dutchman GE, Francis S, Baker DC, Cheng YC: Tylophorine Analog DCB-3503 Inhibited Cyclin D1 Translation through Allosteric Regulation of Heat Shock Cognate Protein 70. Sci Rep. 2016 Sep 6; 2016 Sep 6. PMID: 27596272 Tsou LK, Lara-Tejero M, RoseFigura J, Zhang ZJ, Wang YC, Yount JS, Lefebre M, Dossa PD, Kato J, Guan F, Lam W, Cheng YC, Galán JE, Hang HC: Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. J Am Chem Soc. 2016 Feb 24; 2016 Feb 16. PMID: 26847396 Qin XJ, Yu MY, Ni W, Yan H, Chen CX, Cheng YC, He L, Liu HY: Steroidal saponins from stems and leaves of Paris polyphylla var. yunnanensis. Phytochemistry. 2016 Jan; 2015 Nov 3. PMID: 26546502 Wang J, Jiang Z, Lam W, Gullen EA, Yu Z, Wei Y, Wang L, Zeiss C, Beck A, Cheng EC, Wu C, Cheng YC, Zhang Y: Study of Malformin C, a Fungal Source Cyclic Pentapeptide, as an Anti-Cancer Drug. PLoS One. 2015; 2015 Nov 5. PMID: 26540166 Martín Sánchez C, Pérez Martín JM, Jin JS, Dávalos A, Zhang W, de la Peña G, Martínez-Botas J, Rodríguez-Acebes S, Suárez Y, Hazen MJ, Gómez-Coronado D, Busto R, Cheng YC, Lasunción MA: Disruption of the mevalonate pathway induces dNTP depletion and DNA damage. Biochim Biophys Acta. 2015 Sep; 2015 Jun 5. PMID: 26055626 Wu L, Sun W, Wang B, Zhao H, Li Y, Cai S, Xiang L, Zhu Y, Yao H, Song J, Cheng YC, Chen S: An integrated system for identifying the hidden assassins in traditional medicines containing aristolochic acids. Sci Rep. 2015 Aug 13; 2015 Aug 13. PMID: 26270958 Lam W, Jiang Z, Guan F, Huang X, Hu R, Wang J, Bussom S, Liu SH, Zhao H, Yen Y, Cheng YC: PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment. Sci Rep. 2015 Mar 30; 2015 Mar 30. PMID: 25819872 Liu SH, Chuang WC, Lam W, Jiang Z, Cheng YC: Safety surveillance of traditional Chinese medicine: current and future. Drug Saf. 2015 Feb. PMID: 25647717 Cheng YC: Opportunities for traditional Chinese medicine to address unmet challenges in modern healthcare. J Tradit Complement Med. 2015 Jan; 2015 Jan 7. PMID: 26151011 Lam W, Jiang Z, Guan F, Hu R, Liu SH, Chu E, Cheng YC: The number of intestinal bacteria is not critical for the enhancement of antitumor activity and reduction of intestinal toxicity of irinotecan by the Chinese herbal medicine PHY906 (KD018). BMC Complement Altern Med. 2014 Dec 15; 2014 Dec 15. PMID: 25510341 Fan J, Wang Y, Xiong H, Guo X, Cheng YC: Impact of the rtI187V polymerase substitution of hepatitis B virus on viral replication and antiviral drug susceptibility. J Gen Virol. 2014 Nov; 2014 Jul 15. PMID: 25028473