Chang, Sandy - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Chang graduated with a BS from Yale College in 1988, and obtained his MD from Cornell University Medical College and his PhD from Rockefeller University in 1997. He completed residency in Clinical Pathology at the Brigham and Women's Hospital, and did his postdoctoral fellowship with Dr. Ronald DePinho at the Dana Farber Cancer Institute, Harvard Medical School. He was an Assistant and then Associate Professor in the Department of Genetics, MD Anderson Cancer Center, before joining the faculty at Yale Medical School as a tenured Associate Professor in 2010. Dr. Chang's research interests focuses on how telomeres, protein/DNA structures at the ends of chromosomes, are properly maintained to protect chromosome ends from engaging a DNA damage response. Dr. Chang is the recipient of numerous awards, including those from the Howard Hughes Medical Institute, the Ellsion Medical Foundation, the Sidney Kimmel Foundation for Cancer Research, and the Ellis Benson Award from the Academy of Clinical Laboratory Physicians and Scientists. He was elected into the American Society of Clinical Investigation in 2009. MD Cornell University Medical College (1997) PhD Rockefeller University (1996) BS Yale University (1988) Resident Brigham & Women's Hospital Resident Brigham & Women's Hospital Board Certification AB of Pathology, Clinical Pathology (2003)

研究领域

DNA Damage; Molecular Biology; Pathology; Werner Syndrome; Telomere-Binding Proteins

近期论文

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NBS1 Phosphorylation Status Dictates Repair Choice of Dysfunctional Telomeres. Rai R, Hu C, Broton C, Chen Y, Lei M, Chang S. Molecular Cell. 2017 Mar 2;65(5):801-817.e4. doi: 10.1016/j.molcel.2017.01.016. Epub 2017 Feb 16. TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Rai R, Chen Y, Lei M, Chang S. Nat Commun. 2016 Mar 4;7:10881. doi: 10.1038/ncomms10881. Pot1 OB-fold mutations unleash telomere instability to initiate tumorigenesis. Gu P, Wang Y, Bisht KK, Wu L, Kukova L, Smith EM, Xiao Y, Bailey SM, Lei M, Nandakumar J, Chang S. Oncogene. 2016 Nov 21. doi: 10.1038/onc.2016.405. Cancer chromosomes going to POT1 Chang S. 2013. Cancer chromosomes going to POT1. Nat Genet. 45(5):473-475. Single strand binding proteins 1 and 2 protect newly replicated telomeres Gu P, Deng W, Lei M, and Chang S. 2013. Single strand binding proteins 1 and 2 protect newly replicated telomeres. Cell Research 23(5):705-719. See accompanying review "Mouse models uncap novel roles of SSBs" Bain AL, Shi W, Khanna KK. 2013 Cell Res. 2013 Jun;23(6):744-5. Chromosome ends teach unexpected lessons on DNA damage signalling Chang S. 2012. Chromosome ends teach unexpected lessons on DNA damage signalling. EMBO J. 31:3380-3381. Cooperation between p53 and the telomere-protecting shelter in component Pot1a in endometrial carcinogenesis Akbay EA, Peña CG, Ruder D, Michel JA, Nakada Y, Pathak S, Multani AS, Chang S, Castrillon DH. 2012. Cooperation between p53 and the telomere-protecting shelter in component Pot1a in endometrial carcinogenesis. Oncogene 32(17):2211-2219. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion Gu P, Min JN, Wang Y, Huang C, Peng T, Chai W, Chang S. 2012. CTC1 deletion results in defective telomere replication, leading to catastrophic telomere loss and stem cell exhaustion. EMBO J. 31(10):2309-23021. Essential roles for Pot1b in hematopoietic stem cell self-renewal and survival Wang Y, Shen MF, Chang S. 2011. Essential roles for Pot1b in hematopoietic stem cell self-renewal and survival. Blood 118(23):6068-6077. The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection Rai R, Li JM, Zheng H, Lok G, Deng Y, Huen M, Chen J, Jin J and Chang S. 2011. The E3 ubiquitin ligase RNF8 stabilizes TPP1 to promote telomere end protection. Nature Structural and Molecular Biology 18(12):1400-1407. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA Flynn RL, Centore RC, O’Sullivan RJ, Rai R, Tse A, Songyang Z, Chang S, Karlseder J, and Zou L. 2011. TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA. Nature. 471(7339):532-536. A conserved motif within RAP1 plays diversified roles in telomere protection and regulation in different organisms. Chen Y, Rai R, Zhou ZR, Kanoh J, Ribeyre C, et al . 2011. A conserved motif within RAP1 plays diversified roles in telomere protection and regulation in different organisms. Nature Structural and Molecular Biology 18: 213-221. The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres Rai R, Zheng H, He H, Luo Y, Multani A, Carpenter PB, Chang S. 2010. The function of classical and alternative non-homologous end-joining pathways in the fusion of dysfunctional telomeres. EMBO J. 29(15):2598-610. SNMIB/Apollo generates 3’ single-stranded overhangs at leading-strand telomeres to protect against NHEJ-mediated repair Lam YC, Akhter S, Gu P, Bailey SM, Legerski RJ and Chang S. 2010. SNMIB/Apollo generates 3’ single-stranded overhangs at leading-strand telomeres to protect against NHEJ-mediated repair. EMBO J. (2010) 29(13):2230-41.