Carrasco, Nancy - Yale University - Biological & Biomedical Sciences

个人简介

Nancy Carrasco received her M.D. and Masters in Biochemistry degrees from the National Autonomous University of Mexico and did her postdoctoral training at the Roche Institute of Molecular Biology. She joined the Department of Molecular Pharmacology at the Albert Einstein College of Medicine as a faculty member in 1987 and the Department of Cellular and Molecular Physiology at the Yale School of Medicine in 2011. She is the recipient of the Pew Award in the Biomedical Sciences, the Arnold and Mabel Beckman Foundation Award, the Maria Sibylla Merian Award (Germany), the Merck Prize from the European Thyroid Association (Poland), the Marshall S. Horwitz Faculty Award (New York), and the Light of Life Award (New York), among others. She delivered the Rose Pitt-Rivers Lecture (Scotland) and the American Thyroid Association Plenary Lecture (Canada), and was named Coleman Fellow in the Life Sciences (Israel), among many other honors. Her research on the Na+/I- symporter (NIS), the key plasma membrane protein that mediates active iodide transport in the thyroid, lactating breast, and other tissues, ranges from biochemical, biophysical, and physiological investigations to translational studies. She has served as president of the Society of Latin American Biophysicists. Dr. Carrasco was elected to the National Academy of Sciences in 2015. MS National Autonomous University of Mexico(UNAM), Biochemistry (1981) MD National Autonomous University of Mexico (UNAM) (1980) Fellow Roche Institute of Molecular Biology Fellow UNAM

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Nicola, JP., Carrasco, N*. and Amzel, LM* (2014) “Physiological Na+ concentra-tions enhance the I- affinity of the Na+/I- symporter (NIS)” Nature Comm 3;5:3948. doi: 10.1038/ncomms4948.PMID: 24888603 *co-corrresponding authors Highlighted in Science (2014), 344, 1355. Li W, Nicola JP, Amzel LM, and Carrasco N (2013) “Asn441 plays a key role in folding and function of the Na+/I- symporter (NIS)” FASEB J May 6. [Epub ahead of print] PMID: 23650190 Paroder V, Nicola JP, Ginter CS, and Carrasco N. (2013) “The iodide transport defect-causing mutation R124H: a d-amino group at position 124 is critical for maturation and trafficking of the Na+/I- symporter (NIS)” J. Cell Science May 20. [Epub ahead of print] PMID: 23690546 Paroder-Belenitsky M, Maestas MJ, Dohán O, Nicola JP, Reyna-Neyra A, Follenzi A, Dadachova E, Eskandari S, Amzel LM, Carrasco N. (2011) “Mechanism of anion selectivity and stoichiometry of the Na+/I- symporter (NIS)” Proc Natl Acad Sci USA. 108, 17933-17938. Epub 2011 Oct 19. Evaluated by “Faculty of 1000.” Roepke TK, King EC, Reyna-Neyra A, Paroder M, Purtell K, Koba W, Fine E, Lerner DJ, Carrasco N, Abbott GW (2009). "kcne2 deletion uncovers its critical role in thyroid hormone synthesis" Nature Medicine 15, 1186-1194. Epub Sep 20. Evaluated in: “Faculty of 1000.”, 2009. •Dohán O, Portulano C, Basquin C, Reyna-Neyra A, Amzel LM, and Carrasco N. (2007) "The Na+/I- symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate" Proc Natl Acad Sci USA Dec 104, 20250-20255. Epub 2007 Dec De la Vieja A, Reed M, Ginter CS, and Carrasco N. (2007) "Amino acid residues in transmembrane segment IX of the Na+/I- symporter (NIS) play a role in its Na+ dependence and are critical for transport activity" J Biol Chem 282, 25290-25298. Epub Jul 2. Ferrandino, G., Nicola, JP, Sánchez YE., Echeverría, I., Liu, Y., Amzel, L.M., and Carrasco, N (2016) Na+ coordination at the Na2 site of the Na+/I- symporter (NIS) Proc Natl Acad Sci USA. 13;113(37):E5379-88. doi: 10.1073/pnas.1607231113 • Nagarajah, J., Le, M., Knauf JA, Ferrandino G., Montero-Conde C., Pillarsetty N., Bolaender A., Irwin CP., Krishnamoorthy GP., Saqcena M., Larson, S., Ho AL., Seshan V., Ishii, N., Carrasco N., Rosen N., Weber WA., and Fagin JA (2016) “Sustained ERK inhibition maximizes responses of BrafV600E thyroid cancers to radioiodine” J Clin Invest 126(11):4119-4124. doi:10.1172/JCI89067