Caplan, Michael J - Yale University - Biological & Biomedical Sciences

个人简介

Michael J. Caplan received his bachelors degree from Harvard University and his M.D. and Ph.D. degrees from Yale University in 1987. He joined Yale's Department of Cellular and Molecular Physiology as a faculty member in 1988, and is currently the C.N.H. Long Professor of Cellular and Molecular Physiology and Cell Biology. He has received fellowships from the Helen Hay Whitney Foundation, the David and Lucille Packard Foundation for Science and Engineering, and a National Young Investigator Award from the National Science Foundation. He has also received the Young Investigator Awards from the American Physiological Society and the American Society of Nephrologists. His work focuses on understanding the ways in which kidney cells organize and maintain their unique structures. His laboratory also studies the mechanisms responsible for Autosomal Dominant Polycystic Kidney Disease, and is working to identify targets for new therapies. PhD Yale University (1987) MD Yale University (1987)

研究领域

Cell Biology; Epithelial Cells; Kidney; Polycystic Kidney Diseases; Physiology; Ion Pumps

近期论文

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Mechanical stimuli induce the cleavage and nuclear translocation of the polycystin-1 C-terminus Chauvet V, et al. Mechanical stimuli induce the cleavage and nuclear translocation of the polycystin-1 C-terminus. J Clin Invest, 114:1433-1443, 2004. AMP-activated protein kinase regulates the assembly of epithelial tight junctions Zhang L, Li J, Young LH, Caplan MJ. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA, 103:17272-17277, 2006. MAL decreases the internalization of the aquaporin-2 water channel Kamsteeg EJ, Duffield AS, Konings IBM, Spencer J, Pagel P, Deen PMT, Caplan MJ. MAL decreases the internalization of the aquaporin-2 water channel. Proc Nat Acad Sci USA, 104:16696-16701, 2007. Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling Lal M, Song X, Pluznick JL, Di Giovanni V, Merrick DM, Rosenblum ND, Chauvet V, Gottardi CJ, Pei Y, Caplan MJ. Polycystin-1 C-terminal tail associates with β-catenin and inhibits canonical Wnt signaling. Hum Mol Gen, 17:3105-3117, 2008. Functional expression of the olfactory signaling system in the kidney Pluznick JL, Zou DJ, Zhang X, Yan Q, Rodriguez-Gil DJ, Eisner C, Wells E, Greer CA, Wang T, Firestein S, Schnermann J, Caplan MJ. Functional expression of the olfactory signaling system in the kidney. Proc Nat Acad Sci, 106:2059-2064, 2009. Membrane proteins follow multiple trafficking pathways to the basolateral cell surface in polarized epithelial cells Farr GA, Hull M, Mellman IS, Caplan MJ. Membrane proteins follow multiple trafficking pathways to the basolateral cell surface in polarized epithelial cells. J Cell Biol, 186:269-282, 2009. The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135 Stoops, E.H., M. Hull, C. Olesen, K. Mistry, J.L. Harder, F. Rivera-Molina, D. Toomre, and M.J. Caplan. The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135. J. Cell Biol. 211:287-294, 2015. Dual Pulse Chase Microscopy Reveals Early Divergence in the Biosynthetic Trafficking of the Na, K-ATPase and E-cadherin Farr, G.A., M. Hull, E.H. Stoops, R. Bateson and M.J. Caplan. Dual Pulse Chase Microscopy Reveals Early Divergence in the Biosynthetic Trafficking of the Na, K-ATPase and E-cadherin. Mol. Biol. Cell, 26:4401-4411, 2015. An Olfactory Receptor Responding to Gut Microbiota-Derived Signals Plays a Role in Renin Secretion and Blood Pressure Regulation Pluznick, J.L., R.J. Protzko, H. Gevorgyan, Z. Peterlin, A. Sipos, J. Han, I. Brunet, L.-X. Wan, F.E. Rey, T. Wang, S. Firestein, M. Yanagisawa, J.I. Gordon, A. Eichmann, J. Peti-Peterdi, M.J. Caplan. An Olfactory Receptor Responding to Gut Microbiota-Derived Signals Plays a Role in Renin Secretion and Blood Pressure Regulation. Proc. Nat. Acad. Sci. 110:4410-4415, 2013. The Gamma-secretase cleavage product of Polycystin-1 regulates Tcf and CHOP-mediated transcriptional activation through a p300-dependent mechanism Merrick, D.M., H.C. Chapin, Z. Yu, S. Somlo, J. Hogenesch, and M.J. Caplan. The Gamma-secretase cleavage product of Polycystin-1 regulates Tcf and CHOP-mediated transcriptional activation through a p300-dependent mechanism. Dev. Cell, 22, 197–210, 2012. The polycystins are modulated by cellular oxygen-sensing pathways and regulate mitochondrial function. Padovano V, Kuo IY, Stavola LK, Aerni HR, Flaherty BJ, Chapin HC, Ma M, Somlo S, Boletta A, Ehrlich BE, Rinehart J, Caplan MJ. Mol Biol Cell. Newly synthesized and recycling pools of the apical protein gp135 do not occupy the same compartments. Stoops EH, Hull M, Caplan MJ. Traffic. The periciliary ring in polarized epithelial cells is a hot spot for delivery of the apical protein gp135.