Cantley, Lloyd G - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Cantley performed his clinical Internal Medicine training at the University of North Carolina followed by Nephrology fellowship training at the Beth Israel and Brigham and Women's Hospitals in Boston. He then entered research training at Harvard in the laboratories of Dr. Franklin Epstein and Dr. Guido Guidotti before accepting a faculty position at the Beth Israel. In 2000 Dr. Cantley moved from Harvard to Yale where he established his research focus on the reparative tubular responses to kidney injury. MD West Virginia University (1981) BS West Virginia Wesleyan College (1977) Nephrology Fellow Beth Israel Hospital, Harvard Medical School Resident University of North Carolina Board Certification AB of Internal Medicine, Internal Medicine (1984) Board Certification AB of Internal Medicine, Nephrology (1988)

研究领域

Epithelial Cells; Kidney; Macrophages; Morphogenesis; Nephrology; Physiology

近期论文

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Kidney injury and repair utilize distinct macrophage phenotypes Lee S., Huen S., Nishio H., Nishio S., Lee H.K., Choi B-S., Ruhrberg C., and Cantley L.G. Kidney injury and repair utilize distinct macrophage phenotypes. J. Am. Soc. Nephrol., 2011; 22(2): 317-326. Macrophages promote Cyst Growth in Murine Polycystic Kidney Disease Karihaloo A., Koraishy F., Huen S., Lee Y., Merrick D., Caplan M., Somlo S., and Cantley L.G. Macrophages promote Cyst Growth in Murine Polycystic Kidney Disease. J. Am. Soc. Nephrol., 2011; 22(10):1809-14. Increased tubular proliferation as an adaptive response to glomerular albuminuria Guo J-K., Marlier A., Shi H., Shan A., Ardito T.A., Du Z-P, Kashgarian M., Krause D.S., Biemesderfer D., and Cantley L.G. Increased tubular proliferation as an adaptive response to glomerular albuminuria. J.Am.Soc.Nephrol. 2012; 23(3):429-437. Chitinase 3-like 1 regulates the renal response to ischemic injury and predicts delayed allograft function Schmidt I., Hall I.E., Kale S., Lee S., Lin S.R., He C.H., Lee Y., Chupp G., Moeckel G., Lee C.G., Elias J.A., Parikh C.R., and Cantley L.G. Chitinase 3-like 1 regulates the renal response to ischemic injury and predicts delayed allograft function. J.Am.Soc.Nephol. 2013; 24(2): 309-19. Brg1 regulates urothelial cell fate during ureter development Weiss R.M., Guo S., Shan A., Shi H., Romano R-A., Sinha S., Cantley L.G., Guo J-K. Brg1 regulates urothelial cell fate during ureter development. J.Am.Soc.Nephrol. 2013 24(4):618-26. The Terminator mouse: a diphtheria toxin receptor knockin mouse strain for rapid and efficient enrichment of desired cell lineages Guo J-K., Shi H., Koraishy F., Marlier A., Ding Z., Shan A., and Cantley L.G. The Terminator mouse: a diphtheria toxin receptor knockin mouse strain for rapid and efficient enrichment of desired cell lineages. Kid. Int., 2013; 84(5): 1041-1046. Chitinase 3-like-1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2 He C, Lee C., Dela Cruz C., Lee C-M., Zhou Y., Ahangari F., Ma B., Herzog E., Rosenberg S.A., Modis Y., Parikh C., Schmidt I., Cantley L., and Elias J.A. Chitinase 3-like-1 Regulates Cellular and Tissue Responses via IL-13 Receptor α2. Cell Reports, 2013; 4(4): 830-841. Met activation is required for early cytoprotection after ischemic kidney injury Mason S., Hader C., Marlier A., Moeckel G. and Cantley L.G. Met activation is required for early cytoprotection after ischemic kidney injury. J. Am. Soc. Nephrol., 2014; 25(2): 329-337. Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling Koraishy F., D’Alessandri-Silva C., Marlier A., Wu D. and Cantley L.G. Hepatocyte growth factor (Hgf) stimulates low density lipoprotein receptor-related protein (Lrp) 5/6 phosphorylation and promotes canonical Wnt signaling. J. Biol. Chem., 2014; 289(20): 14341-14350. Casein Kinase 2 maintains cytoplasmic localization of Foxc2 Golden D., and Cantley L.G. Casein Kinase 2 maintains cytoplasmic localization of Foxc2. Oncogene, 2015; in press. Granulocyte Macrophage Colony Stimulating Factor Promotes Macrophage Alternative Activation After Renal Ischemia/Reperfusion Injury Huen S.H., Huynh L., Marlier A., Lee Y., Moeckel G.W., and Cantley, L.G. Granulocyte Macrophage Colony Stimulating Factor Promotes Macrophage Alternative Activation After Renal Ischemia/Reperfusion Injury. J. Am. Soc. Nephrol., 2015; in press. Development of a Targeted Urine Proteome Assay for Kidney Diseases Cantley L.G., Colangelo C.M., Stone K.L., Chung L., Belcher J. Abbott T., Cantley J.L., Williams K.R. Parikh C. R. Development of a Targeted Urine Proteome Assay for Kidney Diseases. Proteomics Clin. App., 2015; in press