Bucala, Richard - Yale University - Biological & Biomedical Sciences

个人简介

MD Cornell College (1986) PhD Rockefeller University (1985) BS Yale University (1979) MS Yale University (1979) Fellow Hospital for Special Surgery Resident Brigham & Women's Hospital/Harvard Medical School Visiting Fellow Institut Pasteur, Paris

研究领域

Africa; Epidemiology; Macrophage Migration-Inhibitory Factors; Malaria; Pathology; Public Health; Rheumatology; Stem Cells; Global Health; Communicable Diseases, Emerging; Infectious Disease Medicine

近期论文

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Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus Sreih A, Ezzeddine R, Leng L, Lachance A, Yu G, Mizue Y, Subrahmanyan L, Pons-Estel BA, Abelson AK, Gunnarsson I, Svenungsson E, Cavett J, Glenn S, Zhang L, Montgomery R, Perl A, Salmon J, Alarcón-Riquelme ME, Harley JB, Bucala R. 2011. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus .Arthritis Rheum. 2011 Dec;63(12):3942-51 A small-molecule MIF antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice Leng L, Chen L, Fan J, Greven D, Arjona A, Du X, Austin D, Kashgarian M, Yin Z, Huang XR, Lan HY, Lolis E, Nikolic-Paterson D, Bucala R. 2011. A small-molecule MIF antagonist protects against glomerulonephritis in lupus-prone NZB/NZW F1 and MRL/lpr mice. J Immunol. 186:527-538. PMCID: PMC3124407 Receptor agonists of macrophage migration inhibitory factor Jorgensen WL, Gandavadi S, Du X, Hare AA, Trofimov A, Leng L, Bucala R. 2010. Receptor agonists of macrophage migration inhibitory factor. Bioorg Med Chem Lett. 20:7033-7036. PMCID: PMC2989669 MIF Promoter Polymorphisms and Susceptibility to Severe Malarial Anemia Awandare GA, Martinson JJ, Were T, Ouma C, Davenport GC, Ong'echa JM, Wang W, Leng L, Ferrell RE, Bucala R, Perkins DJ. 2009. MIF Promoter Polymorphisms and Susceptibility to Severe Malarial Anemia. J Infect Dis. 15: 629-637. PMCID: PMC3607439 Macrophage Migration Inhibitory Factor: A Probable Link between Inflammation and Cancer Bucala R, Donnelly SC. 2007. Macrophage Migration Inhibitory Factor: A Probable Link between Inflammation and Cancer. Immunity 26:281-285. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion Arjona A, Foellmer HG, Town T, Leng L, McDonald C, Wang T, Wong SJ, Montgomery RR, Fikrig E, Bucala R. 2007. Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion. J Clin Invest 117:3059-3066. PMCID: PMC1994625 The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity Flaster H, Bernhagen J, Calandra T, Bucala R. 2007. The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity. Mol Endocrinol. 21:1267-1280. Sparkes A, De Baetselier P, Roelants K, De Trez C, Magez S, Van Ginderachter JA, Raes G, Bucala R, Stijlemans B: The non-mammalian MIF superfamily. Immunobiology. 2017 Mar; 2016 Oct 12. PMID: 27780588 Kim BS, Ott V, Boecker AH, Stromps JP, Paul NE, Alharbi Z, Cakmak E, Bernhagen J, Bucala R, Pallua N: The Effect of Antiseptics on Adipose-Derived Stem Cells. Plast Reconstr Surg. 2017 Mar. PMID: 28234837 Rowe MA, Harper LR, McNulty MA, Lau AG, Carlson CS, Leng L, Bucala RJ, Miller RA, Loeser RF: Reduced Osteoarthritis Severity in Aged Mice With Deletion of Macrophage Migration Inhibitory Factor. Arthritis Rheumatol. 2017 Feb. PMID: 27564840 Brocks T, Fedorchenko O, Schliermann N, Stein A, Moll UM, Seegobin S, Dewor M, Hallek M, Marquardt Y, Fietkau K, Heise R, Huth S, Pfister H, Bernhagen J, Bucala R, Baron JM, Fingerle-Rowson G: Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin. FASEB J. 2017 Feb; 2016 Oct 19. PMID: 27825106 Roger T, Schlapbach LJ, Schneider A, Weier M, Wellmann S, Marquis P, Vermijlen D, Sweep FC, Leng L, Bucala R, Calandra T, Giannoni E: Plasma Levels of Macrophage Migration Inhibitory Factor and d-Dopachrome Tautomerase Show a Highly Specific Profile in Early Life. Front Immunol. 2017; 2017 Jan 25. PMID: 28179905 Kim BS, Tilstam PV, Springenberg-Jung K, Boecker AH, Schmitz C, Heinrichs D, Hwang SS, Stromps JP, Ganse B, Kopp R, Knobe M, Bernhagen J, Pallua N, Bucala R: Characterization of adipose tissue macrophages and adipose-derived stem cells in critical wounds. PeerJ. 2017; 2017 Jan 4. PMID: 28070458 Kim BS, Tilstam PV, Hwang SS, Simons D, Schulte W, Leng L, Sauler M, Ganse B, Averdunk L, Kopp R, Stoppe C, Bernhagen J, Pallua N, Bucala R: D-dopachrome tautomerase in adipose tissue inflammation and wound repair. J Cell Mol Med. 2017 Jan; 2016 Sep 7. PMID: 27605340 Yoo SA, Leng L, Kim BJ, Du X, Tilstam PV, Kim KH, Kong JS, Yoon HJ, Liu A, Wang T, Song Y, Sauler M, Bernhagen J, Ritchlin CT, Lee P, Cho CS, Kim WU, Bucala R: MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2016 Dec 6; 2016 Nov 21. PMID: 27872288 Solomon DH, Bucala RJ: Editorial: The Enduring Value of Reporting Randomized Controlled Clinical Trials in Arthritis & Rheumatology: 2016 and Beyond. Arthritis Rheumatol. 2016 Dec; 2016 Oct 24. PMID: 27788296 Meza-Romero R, Benedek G, Jordan K, Leng L, Pantouris G, Lolis E, Bucala R, Vandenbark AA: Modeling of both shared and distinct interactions between MIF and its homologue D-DT with their common receptor CD74. Cytokine. 2016 Dec; 2016 Aug 27. PMID: 27573366 Assis DN, Takahashi H, Leng L, Zeniya M, Boyer JL, Bucala R: A Macrophage Migration Inhibitory Factor Polymorphism Is Associated with Autoimmune Hepatitis Severity in US and Japanese Patients. Dig Dis Sci. 2016 Dec; 2016 Oct 1. PMID: 27696094