Braddock, Demetrios - Yale University - Biological & Biomedical Sciences

个人简介

MD University of Chicago Pritzker School of Medicine (1996) PhD University of Chicago (1994) Fellow Yale University School of Medicine Resident National Cancer Institute, NIH, Laboratory of Pathology Board Certification AB of Pathology, Anatomic Pathology (2000) Board Certification AB of Pathology, Hematology (Pathology) (2012) Demetrios Braddock was born in Tennessee, educated at the University of Chicago, trained at the NIH in Anatomic Pathology and Biophysical Chemistry, and came to Yale in 2004. He practices Hematopathology and leads a laboratory that studies the ENPP enzymes – a family of extracellular enzymes regulating hemostasis, bone mineralization, and vascular development. These studies have progressed to the development of biologic therapeutics for vascular calcification disorders.

研究领域

Calcification, Physiologic; Osteoarthropathy, Primary Hypertrophic; Pathology; Pseudoxanthoma Elasticum; Sickle Cell Trait; Rare Diseases; Vascular Calcification

近期论文

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ENPP1-Fc Fusion Protein Prevents Mortality and Vascular Calcifications in Rodent Model of Generalized Calcification of Infancy Nature Communications, (2015) Dec 1;6:10006 The Molecular Basis of Purinergic Signal Metabolism by Ecto-Nucleotide Phosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke (2014) J Biol Chem. Feb 7;289(6):3294-306 NPP4 is a procoagulant enzyme on the surface of vascular endothelium Blood, (2012) 120:4432-4440. Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition (2008) EMBO, 27 277-289 Bahal R, Ali McNeer N, Quijano E, Liu Y, Sulkowski P, Turchick A, Lu YC, Bhunia DC, Manna A, Greiner DL, Brehm MA, Cheng CJ, López-Giráldez F, Ricciardi A, Beloor J, Krause DS, Kumar P, Gallagher PG, Braddock DT, Mark Saltzman W, Ly DH, Glazer PM: In vivo correction of anaemia in β-thalassemic mice by γPNA-mediated gene editing with nanoparticle delivery. Nat Commun. 2016 Oct 26; 2016 Oct 26. PMID: 27782131 Albright RA, Stabach P, Cao W, Kavanagh D, Mullen I, Braddock AA, Covo MS, Tehan M, Yang G, Cheng Z, Bouchard K, Yu ZX, Thorn S, Wang X, Folta-Stogniew EJ, Negrete A, Sinusas AJ, Shiloach J, Zubal G, Madri JA, De La Cruz EM, Braddock DT: ENPP1-Fc prevents mortality and vascular calcifications in rodent model of generalized arterial calcification of infancy. Nat Commun. 2015 Dec 1; 2015 Dec 1. PMID: 26624227 Cheng CJ, Bahal R, Babar IA, Pincus Z, Barrera F, Liu C, Svoronos A, Braddock DT, Glazer PM, Engelman DM, Saltzman WM, Slack FJ: MicroRNA silencing for cancer therapy targeted to the tumour microenvironment. Nature. 2015 Feb 5; 2014 Nov 17. PMID: 25409146 Madiraju AK, Erion DM, Rahimi Y, Zhang XM, Braddock DT, Albright RA, Prigaro BJ, Wood JL, Bhanot S, MacDonald MJ, Jurczak MJ, Camporez JP, Lee HY, Cline GW, Samuel VT, Kibbey RG, Shulman GI: Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase. Nature. 2014 Jun 26; 2014 May 21. PMID: 24847880 Albright RA, Ornstein DL, Cao W, Chang WC, Robert D, Tehan M, Hoyer D, Liu L, Stabach P, Yang G, De La Cruz EM, Braddock DT: Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem. 2014 Feb 7; 2013 Dec 12. PMID: 24338010 Albright RA, Chang WC, Robert D, Ornstein DL, Cao W, Liu L, Redick ME, Young JI, De La Cruz EM, Braddock DT: NPP4 is a procoagulant enzyme on the surface of vascular endothelium. Blood. 2012 Nov 22; 2012 Sep 20. PMID: 22995898 Saunders LP, Cao W, Chang WC, Albright RA, Braddock DT, De La Cruz EM: Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution. J Biol Chem. 2011 Aug 26; 2011 Jun 30. PMID: 21719699 Hsiao HH, Nath A, Lin CY, Folta-Stogniew EJ, Rhoades E, Braddock DT: Quantitative characterization of the interactions among c-myc transcriptional regulators FUSE, FBP, and FIR. Biochemistry. 2010 Jun 8. PMID: 20420426 Braddock DT: Autotaxin and lipid signaling pathways as anticancer targets. Curr Opin Investig Drugs. 2010 Jun. PMID: 20496257 Saunders LP, Ouellette A, Bandle R, Chang WC, Zhou H, Misra RN, De La Cruz EM, Braddock DT: Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion. Mol Cancer Ther. 2008 Oct. PMID: 18852138 Ornstein DL, Bifulco CB, Braddock DT, Howe JG: Histopathologic and molecular aspects of CD56+ natural killer/ T-cell lymphoma of the testis. Int J Surg Pathol. 2008 Jul. PMID: 18573785 Crichlow GV, Zhou H, Hsiao HH, Frederick KB, Debrosse M, Yang Y, Folta-Stogniew EJ, Chung HJ, Fan C, De la Cruz EM, Levens D, Lolis E, Braddock D: Dimerization of FIR upon FUSE DNA binding suggests a mechanism of c-myc inhibition. EMBO J. 2008 Jan 9; 2007 Dec 6. PMID: 18059478