Bordey, Angelique - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Angélique Bordey holds the rank of Professor of Neuroscience. Dr. Bordey is an active participant in teaching and training of graduate and medical students at Yale School of Medicine. Dr. Bordey is the Editor-in-Chief of the journal Frontiers in Neurogenesis and an executive Editor of the journals Neuropharmacology, Glia, Neuroplasticity, AES Neuro, Neurogenesis, and Fronteirs in Neuroscience. She has served as an Ad Hoc member on several study sections and is presently a member of CMBG NIH study section . She has organized several national and international symposiums, and is frequently an invited speaker. Finally, she is a McKnight awardee and holds several grant fundings. PhD Louis Pasteur University (1995) MS University Louis Pasteur, Strasbourg, Neurophysiology (1992) MS National School of Engineering, Lyon, Chemistry (1991) Postdoctoral Fellow University of Alabama at Birmingham

研究领域

Autistic Disorder; Central Nervous System Diseases; Nervous System Malformations; Nervous System Diseases; Neurologic Manifestations; Neurosurgery; Physiology; Stem Cells; Diseases

近期论文

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Single-cell Tsc1 knockout during murine corticogenesis generates tuber-like lesions and reduces seizure threshold without astrogliosis Feliciano DM, Su T, Lopez J, Platel JC, and Bordey A. Single-cell Tsc1 knockout during murine corticogenesis generates tuber-like lesions and reduces seizure threshold without astrogliosis. Journal of Clinical Investigation (2011) 121:1596. NMDA receptors activated by glutamate released from astrocyte-like cells are critical for postnatal subventricular neurogenesis Platel JC, Dave KA, Lacar B, Gordon, V, Rubio ME, and Bordey A. NMDA receptors activated by glutamate released from astrocyte-like cells are critical for postnatal subventricular neurogenesis. Neuron. (2010) 65:859-872. GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches Young SZ and Bordey A. GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches. Physiol, 24:171-85, 2009. The astrocyte odyssey Wang DD and Bordey A. The astrocyte odyssey. Prog Neurobiol, 86(4):342-67, 2008. Nonsynaptic GABAergic signaling in the postnatal subventricular zone controls GFAP-expressing cell proliferation Liu X, Wang Q, Haydar TF, Bordey A. Nonsynaptic GABAergic signaling in the postnatal subventricular zone controls GFAP-expressing cell proliferation. Nature Neurosci, 8:1179-87, 2005. Hsieh LS, Wen JH, Miyares L, Lombroso PJ, Bordey A: Outbred CD1 mice are as suitable as inbred C57BL/6J mice in performing social tasks. Neurosci Lett. 2017 Jan 10; 2016 Nov 18. PMID: 27871995 Bartley CM, O'Keefe RA, Blice-Baum A, Mihailescu MR, Gong X, Miyares L, Karaca E, Bordey A: Mammalian FMRP S499 Is Phosphorylated by CK2 and Promotes Secondary Phosphorylation of FMRP. eNeuro. 2016 Nov-Dec; 2016 Nov 21. PMID: 27957526 Lin TV, Hsieh L, Kimura T, Malone TJ, Bordey A: Normalizing translation through 4E-BP prevents mTOR-driven cortical mislamination and ameliorates aberrant neuron integration. Proc Natl Acad Sci U S A. 2016 Oct 4; 2016 Sep 19. PMID: 27647922 Zhang L, Huang T, Bordey A: Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels. Neurosci Lett. 2016 Aug 26; 2016 Jun 21. PMID: 27345385 Jung Y, Hsieh LS, Lee AM, Zhou Z, Coman D, Heath CJ, Hyder F, Mineur YS, Yuan Q, Goldman D, Bordey A, Picciotto MR: An epigenetic mechanism mediates developmental nicotine effects on neuronal structure and behavior. Nat Neurosci. 2016 Jul; 2016 May 30. PMID: 27239938 Hsieh LS, Wen JH, Claycomb K, Huang Y, Harrsch FA, Naegele JR, Hyder F, Buchanan GF, Bordey A: Convulsive seizures from experimental focal cortical dysplasia occur independently of cell misplacement. Nat Commun. 2016 Jun 1; 2016 Jun 1. PMID: 27249187 Mahoney C, Feliciano DM, Bordey A, Hartman NW: Switching on mTORC1 induces neurogenesis but not proliferation in neural stem cells of young mice. Neurosci Lett. 2016 Feb 12; 2016 Jan 23. PMID: 26812181 Zhang L, Feliciano DM, Huang T, Zhang S, Bordey A: Hypoxia-inducible factor-1a contributes to dendritic overgrowth in tuberous sclerosis. Neurosci Lett. 2016 Jan 26; 2015 Dec 2. PMID: 26655465 Gong X, Zhang L, Huang T, Lin TV, Miyares L, Wen J, Hsieh L, Bordey A: Activating the translational repressor 4E-BP or reducing S6K-GSK3β activity prevents accelerated axon growth induced by hyperactive mTOR in vivo. Hum Mol Genet. 2015 Oct 15; 2015 Jul 28. PMID: 26220974 Feliciano DM, Bordey A, Bonfanti L: Noncanonical Sites of Adult Neurogenesis in the Mammalian Brain. Cold Spring Harb Perspect Biol. 2015 Sep 18; 2015 Sep 18. PMID: 26384869 Rela L, Piantanida AP, Bordey A, Greer CA: Voltage-dependent K+ currents contribute to heterogeneity of olfactory ensheathing cells. Glia. 2015 Sep; 2015 Apr 9. PMID: 25856239 Zhang L, Bartley CM, Gong X, Hsieh LS, Lin TV, Feliciano DM, Bordey A: MEK-ERK1/2-dependent FLNA overexpression promotes abnormal dendritic patterning in tuberous sclerosis independent of mTOR. Neuron. 2014 Oct 1. PMID: 25277454 Bartley CM, O'Keefe RA, Bordey A: FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity. PLoS One. 2014; 2014 May 7. PMID: 24806451