Bender, Jeffrey R - Yale University - Biological & Biomedical Sciences

个人简介

MD University of California/San Francisco (1979) Fellow Stanford University Resident Yale-New Haven Hospital Board Certification AB of Internal Medicine, Internal Medicine (1983) Board Certification AB of Internal Medicine, Cardiovascular Disease (1985)

研究领域

Cardiology; Endothelium; Immune System; Inflammation; Macrophages; T-Lymphocytes; RNA Stability

近期论文

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Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1β Production. Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi MM, Bender JR, Morrison AR. Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):328-340. doi: 10.1161/ATVBAHA.116.308507. Chemokine-coupled ß2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR. Chemokine-coupled ß2 integrin-induced macrophage Rac2-Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. J Exp Med. 2014 Sep 22;211(10):1957-68. doi: 10.1084/jem.20132130. PMID:25180062 Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis Mehra VC, Jackson E, Zhang XM, Jiang XC, Dobrucki LW, Yu J, Bernatchez P, Sinusas AJ, Shulman GI, Sessa WC, Yarovinsky TO, Bender JR. Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis. Am J Pathol. 2014 May;184(5):1562-76. PMID: 24606881 Endothelial estrogen receptor isoforms and cardiovascular disease Kim KH, Young BD, Bender JR. Endothelial estrogen receptor isoforms and cardiovascular disease. Mol Cell Endocrinol. 2014 May 25;389(1-2):65-70. PMID: 24530925 The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes Crespo CL, Vernieri C, Keller PJ, Garrè M, Bender JR, Wittbrodt J, Pardi R.The PAR complex controls the spatiotemporal dynamics of F-actin and the MTOC in directionally migrating leukocytes. J Cell Sci. 2014 Sep 1. pii: jcs.146217. [Epub ahead of print] PMID:25179599 Silver lining in the dark cloud of aneurysm disease Chau KH, Bender JR, Elefteriades JA. Silver lining in the dark cloud of aneurysm disease. Cardiology. 2014;128(4):327-32. doi: 10.1159/000358123. Epub 2014 Jun 17. PMID: 24942201 Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis Nie L, Guo X, Esmailzadeh L, Zhang J, Asadi A, Collinge M, Li X, Kim JD, Woolls M, Jin SW, Dubrac A, Eichmann A, Simons M, Bender JR, Sadeghi MM. Transmembrane protein ESDN promotes endothelial VEGF signaling and regulates angiogenesis. J Clin Invest. 2013 ;123(12):5082-97. Macrophage ß2 integrin-mediated, HuR-dependent stablization of angiogenic-factor encoding mRNAs in inflammatory angiogenesis Zhang, J., Modi, Y., Yarovinsky, T., Yu, J., Collinge, M., Kyriakides, T., Zhu, Z., Sessa, W.C., Pardi, R., Bender, J.R.: Macrophage ß2 integrin-mediated, HuR-dependent stablization of angiogenic-factor encoding mRNAs in inflammatory angiogenesis. Am. J. Pathol. 180:1751-1760, 2012. Splice isoform estrogen receptors as integral transmembrane proteins Kim, K.H., Toomre, D., Bender, J.R.: Splice isoform estrogen receptors as integral transmembrane proteins. Mol. Biol. Cell. 22:4415-4423, 2011. PMID: 21937726 Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis Zhang J, Razavian M, Tavakoli S, Nie L, Tellides G, Backer JM, Backer MV, Bender JR, Sadeghi MM. Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis. Arterioscler Thromb Vasc Biol. 2012 Aug;32(8):1849-55. PMID:22723442 T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac 1/2, p38MAPK and MKK3 signaling cascade Ramgolam V.S., DeGregorio S.D., Rao G.K., Collinge M, Subaran S, Markovic-Plese S, Pardi R, Bender J.R.: T cell LFA-1 engagement induces HuR-dependent cytokine mRNA stabilization through a Vav-1, Rac 1/2, p38MAPK and MKK3 signaling cascade. PLoS ONE: 5(12):e14450, 2010. PMID: 21206905 Menopause and the Heart Nkonde-Price, C., Bender, J.R.: Menopause and the Heart, in: H. Taylor, M.J. Minkin, ed., Menopause, Oxford Press, in press. VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling Zhang, J., Yarovinsky, T., Manes, T., Silva, T., Tellides, G., Pober, J.S., Bender, J.R., Sadeghi, M.M.: VEGF blockade inhibits lymphocyte recruitment and ameliorates immune-mediated vascular remodeling. Circ. Res., 107(3):408-17, 2010. PMID: 20538685 Endothelial and smooth muscle-derived neuropilin-like protein regulates platelet-derived growth factor signaling in human vascular smooth muscle cells by modulating receptor ubiquitination