Mamoun, Choukri Ben - Yale University - Biological & Biomedical Sciences

个人简介

PhD University of Paris (1996)

研究领域

Malaria; Plasmodium falciparum; Babesia microti; Infectious Disease Medicine

近期论文

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Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone Lawres LA, Garg A, Kumar V, Bruzual I, Forquer IP, Renard I, Virji AZ, Boulard P, Rodriguez EX, Allen AJ, Pou S, Wegmann KW, Winter RW, Nilsen A, Mao J, Preston DA, Belperron AA, Bockenstedt LK, Hinrichs DJ, Riscoe MK, Doggett JS, Ben Mamoun C. Radical cure of experimental babesiosis in immunodeficient mice using a combination of an endochin-like quinolone and atovaquone. Journal of Experimental Medicine. 2016. PubMed PMID: 27270894; PubMed Central PMCID: PMC4925016. A targeted immunomic approach identifies diagnostic antigens in the human pathogen Babesia microti Cornillot E, Dassouli A, Pachikara N, Lawres L, Renard I, Francois C, Randazzo S, Brès V, Garg A, Brancato J, Pazzi JE, Pablo J, Hung C, Teng A, Shandling AD, Huynh VT, Krause PJ, Lepore T, Delbecq S, Hermanson G, Liang X, Williams S, Molina DM, Ben Mamoun C. A targeted immunomic approach identifies diagnostic antigens in the human pathogen Babesia microti. Transfusion. 2016 May 17. doi: 10.1111/trf.13640. [Epub ahead of print] PubMed PMID: 27184823. Characterization of Plasmodium phosphatidylserine decarboxylase expressed in yeast and application for inhibitor screening Choi JY, Kumar V, Pachikara N, Garg A, Lawres L, Toh JY, Voelker DR, Ben Mamoun C. Characterization of Plasmodium phosphatidylserine decarboxylase expressed in yeast and application for inhibitor screening. Mol Microbiol. 2016 Mar;99(6):999-1014. doi: 10.1111/mmi.13280. Epub 2015 Dec 22. PubMed PMID: 26585333; PubMed Central PMCID: PMC4898484. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum Garg A, Wesolowski D, Alonso D, Deitsch KW, Ben Mamoun C, Altman S. Targeting protein translation, RNA splicing, and degradation by morpholino-based conjugates in Plasmodium falciparum. Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11935-40. doi: 10.1073/pnas.1515864112. Epub 2015 Sep 8. PubMed PMID: 26351679; PubMed Central PMCID: PMC4586866. From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE Choi JY, Duraisingh MT, Marti M, Ben Mamoun C, Voelker DR. From Protease to Decarboxylase: THE MOLECULAR METAMORPHOSIS OF PHOSPHATIDYLSERINE DECARBOXYLASE. J Biol Chem. 2015 Apr 24;290(17):10972-80. doi: 10.1074/jbc.M115.642413. Epub 2015 Feb 26. PubMed PMID: 25724650; PubMed Central PMCID: PMC4409258. Babesiosis Vannier EG, Diuk-Wasser MA, Ben Mamoun C, Krause PJ. Babesiosis. Infect Dis Clin North Am. 2015 Jun;29(2):357-70. doi: 10.1016/j.idc.2015.02.008. Review. PubMed PMID: 25999229; PubMed Central PMCID: PMC4458703. Structure, function and inhibition of the phosphoethanolamine methyltransferases of the human malaria parasites Plasmodium vivax and Plasmodium knowlesi Garg A, Lukk T, Kumar V, Choi JY, Augagneur Y, Voelker DR, Nair S, Ben Mamoun C. Structure, function and inhibition of the phosphoethanolamine methyltransferases of the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Sci Rep. 2015 Mar 12;5:9064. doi: 10.1038/srep09064. PubMed PMID: 25761669; PubMed Central PMCID: PMC4357015. Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission Bobenchik AM, Witola WH, Augagneur Y, Nic Lochlainn L, Garg A, Pachikara N, Choi JY, Zhao YO, Usmani-Brown S, Lee A, Adjalley SH, Samanta S, Fidock DA, Voelker DR, Fikrig E, Ben Mamoun C. Plasmodium falciparum phosphoethanolamine methyltransferase is essential for malaria transmission. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18262-7. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum Augagneur Y, Jaubert L, Schiavoni M, Pachikara N, Garg A, Usmani-Brown S, Wesolowski D, Zeller S, Ghosal A, Cornillot E, Said HM, Kumar P, Altman S, Ben Mamoun C. Identification and functional analysis of the primary pantothenate transporter, PfPAT, of the human malaria parasite Plasmodium falciparum. J Biol Chem. 2013 Jul 12;288(28):20558-67. Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates Cornillot E, Dassouli A, Garg A, Pachikara N, Randazzo S, Depoix D, Carcy B, Delbecq S, Frutos R, Silva JC, Sutton R, Krause PJ, Mamoun CB. Whole genome mapping and re-organization of the nuclear and mitochondrial genomes of Babesia microti isolates. PLoS One. 2013 Sep 4;8(9):e72657. Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum Augagneur Y, Wesolowski D, Tae HS, Altman S, Ben Mamoun C. Gene selective mRNA cleavage inhibits the development of Plasmodium falciparum. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6235-40. Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti Cornillot E, Hadj-Kaddour K, Dassouli A, Noel B, Ranwez V, Vacherie B, Augagneur Y, Brès V, Duclos A, Randazzo S, Carcy B, Debierre-Grockiego F, Delbecq S, Moubri-Ménage K, Shams-Eldin H, Usmani-Brown S, Bringaud F, Wincker P, Vivarès CP, Schwarz RT, Schetters TP, Krause PJ, Gorenflot A, Berry V, Barbe V, Ben Mamoun C. Sequencing of the smallest Apicomplexan genome from the human pathogen Babesia microti. Nucleic Acids Res. 2012 Oct;40(18):9102-14. PG12, a phospholipid analog with potent antimalarial activity, inhibits Plasmodium falciparum CTP:phosphocholine cytidylyltransferase activity