Beardsley, George Peter - Yale University - Biological & Biomedical Sciences

个人简介

MD Duke University (1974) PhD Princeton University (1971) Fellow Harvard University Resident Yale-New Haven Hospital

研究领域

Antiviral Agents; Folic Acid Antagonists; Pediatrics; Osteosarcoma

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Solution Structure of a DNA Dodecamer Containing the Antiviral Drug Ganciclovir: Combined use of NMR, Restrained Molecular Dynamics, and Full Relaxation Matrix Refinement Foti, M., Marshalko, S.J., Schurter, E., Kumar, S., Beardsley G.P., and Schweitzer, B.I. (1997). Solution Structure of a DNA Dodecamer Containing the Antiviral Drug Ganciclovir: Combined use of NMR, Restrained Molecular Dynamics, and Full Relaxation Matrix Refinement. Biochemistry. The human pur H gene product, 5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase / IMP cyclohydrolase Rayl, E., Moroson, B.A., and Beardsley, G.P. (1996). The human pur H gene product, 5-Aminoimidazole-4-carboxamide ribonucleotide formyltransferase / IMP cyclohydrolase. J. Biol. Chem. 271:2225-33. Chiral chemical synthesis of DNA containing \(S\)-9-\(1,3-dihydroxy-2-propoxymethyl\)guanine \(DHPG\) and effects on thermal stability, duplex structure, and thermodynamics of duplex formation Marshalko SJ, Schweitzer BI, Beardsley GP, Chiral chemical synthesis of DNA containing \(S\)-9-\(1,3-dihydroxy-2-propoxymethyl\)guanine \(DHPG\) and effects on thermal stability, duplex structure, and thermodynamics of duplex formation., Biochemistry, 34(28):9235-48, 18 1995 Abstract Effects of Arabinosylcytosine Substituted DNA on DNA/RNA Hybrid Stability and Transcription by T7 RNA Polymerase Mikita, T. and Beardsley, G.P., Effects of Arabinosylcytosine Substituted DNA on DNA/RNA Hybrid Stability and Transcription by T7 RNA Polymerase. Biochemistry, 1994, 33:9195-92 Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis Greasley SE, Horton P, Ramcharan J, Beardsley GP, Benkovic SJ, Wilson IA. Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nature: Struct Biol. 2001 May;8(5):402-6. he kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling Bulock KG, Beardsley GP, Anderson KS. The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J Biol Chem. 2002 Jun 21;277(25):22168-74. Chen H, Beardsley GP, Coen DM: Mechanism of ganciclovir-induced chain termination revealed by resistant viral polymerase mutants with reduced exonuclease activity. Proc Natl Acad Sci U S A. 2014 Dec 9; 2014 Nov 24. PMID: 25422422 Vergis JM, Beardsley GP: Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase. Biochemistry. 2004 Feb 10. PMID: 14756554 Bulock KG, Beardsley GP, Anderson KS: The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J Biol Chem. 2002 Jun 21; 2002 Apr 10. PMID: 11948179 Vergis JM, Bulock KG, Fleming KG, Beardsley GP: Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity. J Biol Chem. 2001 Mar 16; 2000 Nov 28. PMID: 11096114 Cinquina CC, Grogan E, Sun R, Lin SF, Beardsley GP, Miller G: Dihydrofolate reductase from Kaposi's sarcoma-associated herpesvirus. Virology. 2000 Mar 1. PMID: 10683342 Beardsley GP, Rayl EA, Gunn K, Moroson BA, Seow H, Anderson KS, Vergis J, Fleming K, Worland S, Condon B, Davies J: Structure and functional relationships in human pur H. Adv Exp Med Biol. 1998. PMID: 9598063 Rayl EA, Moroson BA, Beardsley GP: The human purH gene product, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase. Cloning, sequencing, expression, purification, kinetic analysis, and domain mapping. J Biol Chem. 1996 Jan 26. PMID: 8567683 Marshalko SJ, Schweitzer BI, Beardsley GP: Chiral chemical synthesis of DNA containing (S)-9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG) and effects on thermal stability, duplex structure, and thermodynamics of duplex formation. Biochemistry. 1995 Jul 18. PMID: 7619825 Pizzorno G, Moroson BA, Cashmore AR, Russello O, Mayer JR, Galivan J, Bunni MA, Priest DG, Beardsley GP: Multifactorial resistance to 5,10-dideazatetrahydrofolic acid in cell lines derived from human lymphoblastic leukemia CCRF-CEM. Cancer Res. 1995 Feb 1. PMID: 7834626 Schweitzer BI, Mikita T, Kellogg GW, Gardner KH, Beardsley GP: Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement. Biochemistry. 1994 Sep 27. PMID: 7918360 Mikita T, Beardsley GP: Effects of arabinosylcytosine-substituted DNA on DNA/RNA hybrid stability and transcription by T7 RNA polymerase. Biochemistry. 1994 Aug 9. PMID: 7519442 Pizzorno G, Cashmore AR, Moroson BA, Cross AD, Smith AK, Marling-Cason M, Kamen BA, Beardsley GP: 5,10-Dideazatetrahydrofolic acid (DDATHF) transport in CCRF-CEM and MA104 cell lines. J Biol Chem. 1993 Jan 15. PMID: 8419310 Pavlovic M, Leffert JJ, Russello O, Bunni MA, Beardsley GP, Priest DG, Pizzorno G: Altered transport of folic acid and antifolates through the carrier mediated reduced folate transport system in a human leukemia cell line resistant to (6R) 5,10-dideazatetrahydrofolic acid (DDATHF). Adv Exp Med Biol. 1993. PMID: 8304227