Baxter, Richard - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Baxter is an expert in structural and functional studies of proteins. His current research focus is the A. gambiae complement pathway. As a postdoctoral fellow he determined the crystal structure of TEP1, the central molecule in this pathway that plays a major role in the mosquitoes immune response to malarial parasites. Ongoing research in Dr. Baxter's laboratory is aimed at understanding the molecular basis of this immune response and the development of novel chemical entities for vector-based malaria control strategies.

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Structural basis for conserved complement factor-like function in the antimalarial protein TEP1 4. Baxter, R.H.G., Chang, C.-I., Chelliah, Y.C., Blandin, S., Levashina, E.A., Deisenhofer, J. (2007) "Structural basis for conserved complement factor-like function in the antimalarial protein TEP1" Proc. Natl. Acad. Sci. USA 104, 11615-11620. [PMID 17606907] Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium. 3. Fraiture, M., Baxter, R.H.G., Steinert, S., Chelliah, Y., Frolet, C., Quispe-Tintaya, W., Hoffmann, J., Blandin, S., Levashina, E. (2009) "Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium" Cell Host Microbe 5, 273-284. [PMID 19286136] A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae Baxter, R.H.G., Volohonsky, G., Chelliah, Y., Steinert, S., Levashina, E.A., Deisenhofer J. (2010) “A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae”, Proc. Natl. Acad. Sci. USA 107, 16817-16822. [PMID 20826443] Baxter RH, Contet A, Krueger K: Arthropod Innate Immune Systems and Vector-Borne Diseases. Biochemistry. 2017 Feb 21; 2017 Feb 8. PMID: 28072517 Bogusz AM, Kovach AE, Le LP, Feng D, Baxter RH, Sohani AR: Diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression shows evidence of active B-cell receptor signaling by quantitative immunofluorescence. PLoS One. 2017; 2017 Feb 17. PMID: 28212447 Baxter RH: Chemosterilants for Control of Insects and Insect Vectors of Disease. Chimia (Aarau). 2016 Oct. PMID: 27779930 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P: Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 7; 2016 Mar 7. PMID: 26947396 Mitri C, Bischoff E, Takashima E, Williams M, Eiglmeier K, Pain A, Guelbeogo WM, Gneme A, Brito-Fravallo E, Holm I, Lavazec C, Sagnon N, Baxter RH, Riehle MM, Vernick KD: An Evolution-Based Screen for Genetic Differentiation between Anopheles Sister Taxa Enriches for Detection of Functional Immune Factors. PLoS Pathog. 2015 Dec; 2015 Dec 3. PMID: 26633695 Williams M, Summers BJ, Baxter RH: Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1. PLoS One. 2015; 2015 Mar 16. PMID: 25775123 Dziedzic P, Cisneros JA, Robertson MJ, Hare AA, Danford NE, Baxter RH, Jorgensen WL: Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor. J Am Chem Soc. 2015 Mar 4; 2015 Feb 20. PMID: 25697265 Williams M, Baxter R: The structure and function of thioester-containing proteins in arthropods. Biophys Rev. 2014 Dec; 2014 Jul 19. PMID: 28510031 Williams M, Baxter R: The structure and function of thioester-containing proteins in arthropods. Biophys Rev. 2014 Dec; 2014 Jul 19. PMID: 28373896 Han S, Le BV, Hajare HS, Baxter RH, Miller SJ: X-ray crystal structure of teicoplanin A₂-2 bound to a catalytic peptide sequence via the carrier protein strategy. J Org Chem. 2014 Sep 19; 2014 Sep 2. PMID: 25147913 Le BV, Klöck C, Schatz A, Nguyen JB, Kakani EG, Catteruccia F, Khosla C, Baxter RH: Dihydroisoxazole inhibitors of Anopheles gambiae seminal transglutaminase AgTG3. Malar J. 2014 Jun 2; 2014 Jun 2. PMID: 24888439 Melicher MS, Chu J, Walker AS, Miller SJ, Baxter RH, Schepartz A: A β-boronopeptide bundle of known structure as a vehicle for polyol recognition. Org Lett. 2013 Oct 4; 2013 Sep 13. PMID: 24032486 Le BV, Nguyen JB, Logarajah S, Wang B, Marcus J, Williams HP, Catteruccia F, Baxter RH: Characterization of Anopheles gambiae transglutaminase 3 (AgTG3) and its native substrate Plugin. J Biol Chem. 2013 Feb 15; 2013 Jan 3. PMID: 23288850 Le BV, Williams M, Logarajah S, Baxter RH: Molecular basis for genetic resistance of Anopheles gambiae to Plasmodium: structural analysis of TEP1 susceptible and resistant alleles. PLoS Pathog. 2012; 2012 Oct 4. PMID: 23055931