Aronson, Peter S - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Aronson received his undergraduate education at the University of Rochester and his medical education at New York University. He was an internal medicine resident at the University of North Carolina and a research fellow at the National Institutes of Health before coming to Yale as a renal fellow in 1974. He was Chief of the Section of Nephrology at Yale from 1987-2002. Dr. Aronson has published articles and book chapters on the mechanisms regulating sodium, acid-base, and oxalate excretion by the kidney, particularly as related to the formation of kidney stones. He has received a number of awards for his research work, including the Young Investigator Award of the American Society of Nephrology and American Heart Association in 1985, the Homer W. Smith Award of the ASN in 1994, election to the American Academy of Arts and Sciences in 2009, and the Robert W. Berliner Award of the American Physiological Society in 2016. He served as President of the American Society of Nephrology in 2008. Dr. Aronson actively participates in the teaching of undergraduate, graduate and medical students, as well as residents and fellows. He was a co-recipient of the Charles W. Bohmfalk Teaching Prize in the Basic Sciences in 2005. Dr. Aronson is an Associate Director of the Yale M.D.-Ph.D. Program. MD New York University (1970) AB University of Rochester, General Science (1967) Postdoctoral Fellow in Nephrology Yale School of Medicine Clinical Associate (Research Fellow) Gerontology Research Center, NIH Resident University of North Carolina School of Medicine Board Certification AB of Internal Medicine, Internal Medicine (1973) Board Certification AB of Internal Medicine, Nephrology (1976)

研究领域

Acid-Base Imbalance; Cell Membrane Permeability; Hyperoxaluria; Urinary Tract Physiological Phenomena; Water-Electrolyte Imbalance; Nephrolithiasis; Cell Physiological Processes

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

N-glycosylation critically regulates function of oxalate transporter SLC26A6 Thomson, R.B., Thomson, C.L., and Aronson, P.S. N-glycosylation critically regulates function of oxalate transporter SLC26A6. Am. J. Physiol. in press, 2017. Loss of CFTR impairs intestinal oxalate secretion Knauf, F., Thomson, R.B., Heneghan, J.F., Jiang, Z., Adebamiro, A., Thomson, C.L., Barone, C., Asplin, J.R., Egan, M.E., Alper. S.L., and Aronson, P.S. Loss of CFTR impairs intestinal oxalate secretion. J. Am. Soc. Nephrol., in press, 2016. Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice Mulay, S.R., Eberhard, J.N., Pfann, V., Marschner, J.A., Darisipudi, M.N., Daniel, C., Romoli, S., Desai, J., Grigorescu, M., Kumar, S.V., Rathkolb, B., Wolf, E., Hrabě de Angelis, M., Bäuerle, T., Dietel, B., Wagner, C.A., Amann, K., Eckardt, K.U., Aronson, P.S., Anders, H.J., and Knauf, F. Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice. Am. J. Physiol. in press, 2016. Oxalate, inflammasome, and progression of kidney disease. Ermer, T., Eckardt, K.U., Aronson, P.S., and Knauf, F. Oxalate, inflammasome, and progression of kidney disease. Curr. Opin. Nephrol. Hypertens. 25:363-371, 2016. Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site Chen, T., Kocinsky, H.S., Cha, B., Murtazina, R., Yang, J., Tse, C.M., Singh, V., Cole, R., Aronson, P.S., deJonge, H., Sarker, R., and Donowitz, M. Cyclic GMP kinase II (cGKII) inhibits NHE3 by altering its trafficking and phosphorylating NHE3 at three required sites: identification of a multifunctional phosphorylation site. J. Biol. Chem. 290:1952-1965, 2015. NALP3-mediated inflammation is the principal cause of progressive renal failure in oxalate nephropathy Knauf, F., Asplin, J.R., Granja, I., Schmidt, I.M., Moeckel, G., David, R., Flavell, R.A., and Aronson, P.S. NALP3-mediated inflammation is the principal cause of progressive renal failure in oxalate nephropathy. Kidney Int. 84:895-901, 2013 Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3 Hayashi, H., Tamura, A., Krishnan, D., Tsukita, S., Suzuki, Y., Kocinsky, H.S., Aronson, P.S., Orlowski, J., Grinstein, S., and Alexander, R.T. Ezrin is required for the functional regulation of the epithelial sodium proton exchanger, NHE3. PLoS One 8:e55623, 2013 Sat1 is dispensable for active oxalate secretion in mouse duodenum Ko, N., Knauf, F., Jiang, Z., Markovich, D., and Aronson, P.S. Sat1 is dispensable for active oxalate secretion in mouse duodenum. Am. J. Physiol. 303:C52-C57, 2012. Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells Hassan, H.A., Cheng, M., and Aronson, P.S. Cholinergic signaling inhibits oxalate transport by human intestinal T84 cells. Am. J. Physiol. 302:C46-C58, 2012. Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion Knauf, F., Ko, N., Jiang, Z., Robertson, W.G., Van Itallie, C.M., Anderson, J.M., and Aronson, P.S. Net intestinal transport of oxalate reflects passive absorption and SLC26A6-mediated secretion. J. Am. Soc. Nephrol. 22:2247-2255, 2011. NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity Kocinsky HS, Dynia DW, Wang T, Aronson PS. NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity. Am J Physiol, 293:F212-8, 2007. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6 Jiang Z, Asplin JR, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, Aronson PS. Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet, 38:474-8, 2006.