Arnsten, Amy F. T - Yale University - Biological & Biomedical Sciences

个人简介

Dr. Arnsten was raised in Maplewood, N.J. where she attended Columbia High School. She received her B.A. in Neuroscience from Brown University in 1976, and her Ph.D. in Neuroscience from UCSD in 1981. She did post-doctoral research with Dr. Susan Iversen at Cambridge University in the UK, and with Dr. Patricia Goldman-Rakic at Yale. Dr. Arnsten's research examines the neural basis of higher cognition. Her work has revealed that the newly evolved cortical circuits that underlie higher cognition are uniquely regulated at the molecular level, conferring vulnerability in mental illness and age-related cognitive disorders such as Alzheimer's Disease. Arnsten's research has led to new treatments for cognitive disorders in humans, including the successful translation of guanfacine (IntunivTM) for the treatment of ADHD and related prefrontal cortical disorders. PhD University of California, San Diego (1981)

研究领域

Aging; Alzheimer Disease; Behavioral Sciences; Psychology, Child; Mental Health; Neurobiology; Neurosciences; Stress Disorders, Post-Traumatic; Prefrontal Cortex; Cognitive Science

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Nicotinic a7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex Yang Y, Paspalas CD, Jin LE, Picciotto MR, Arnsten AF, Wang M. (2013) Nicotinic a7 receptors enhance NMDA cognitive circuits in dorsolateral prefrontal cortex. Proc Natl Acad Sci USA 110:12078-83. NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex Wang M, Yang Y, Wang CJ, Gamo NJ, Jin LE, Mazer JA, Morrison JH, Wang XJ, Arnsten AF. (2013) NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex. Neuron 77:736-49. Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses Arnsten AF, Wang MJ, Paspalas CD. (2012) Neuromodulation of thought: flexibilities and vulnerabilities in prefrontal cortical network synapses. Neuron 76:223-39. Dynamic Network Connectivity: A new form of neuroplasticity Arnsten AFT, Paspalas CD, Gamo NJ, Yang Y, Wang M. Dynamic Network Connectivity: A new form of neuroplasticity. Trends in Cognitive Sciences, 4: 365-75, 2010. Stress signalling pathways that impair prefrontal cortex structure and function Stress signalling pathways that impair prefrontal cortex structure and function. Arnsten AF. Nat Rev Neurosci. 2009 Jun;10(6):410-22. Review. PMID: 19455173 [PubMed - indexed for MEDLINE] Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory Vijayraghavan, S., Wang, M., Birnbaum, S.G., Bruce, C.J., Williams, G.V., and Arnsten, A.F.T. (2007). Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nature Neurosci. 10:376-84. Alpha-2A-Adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex Wang, M., et al. (2007). Alpha-2A-Adrenoceptors strengthen working memory networks by inhibiting cAMP-HCN channel signaling in prefrontal cortex. Cell 129:397-410. cAMP-PKA phosphorylation of tau confers risk for degeneration in aging association cortex. Carlyle BC, Nairn AC, Wang M, Yang Y, Jin LE, Simen AA, Ramos BP, Bordner KA, Craft GE, Davies P, Pletikos M, Šestan N, Arnsten AF, Paspalas CD. Proc Natl Acad Sci U S A 111:5036-41, 2014. Stress weakens prefrontal networks: molecular insults to higher cognition. Arnsten AF. Nat Neurosci.;18:1376-85 Dopamine's Actions in Primate Prefrontal Cortex: Challenges for Treating Cognitive Disorders. Arnsten AF, Wang M, Paspalas CD. Pharmacol Rev. 67:681-96 Morozov YM, Datta D, Paspalas CD, Arnsten AF: Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex. Neurobiol Aging. 2017 Mar; 2016 Dec 10. PMID: 28027494 Jin LE, Wang M, Galvin VC, Lightbourne TC, Conn PJ, Arnsten AF, Paspalas CD: mGluR2 versus mGluR3 Metabotropic Glutamate Receptors in Primate Dorsolateral Prefrontal Cortex: Postsynaptic mGluR3 Strengthen Working Memory Networks. Cereb Cortex. 2017 Jan 19; 2017 Jan 19. PMID: 28108498 Arnsten AF, Girgis RR, Gray DL, Mailman RB: Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia. Biol Psychiatry. 2017 Jan 1; 2016 Jan 18. PMID: 26946382 Krystal JH, Abi-Dargham A, Akbarian S, Arnsten AF, Barch DM, Bearden CE, Braff DL, Brown ES, Bullmore ET, Carlezon WA Jr, Carter CS, Cook EH Jr, Daskalakis ZJ, DiLeone RJ, Duman RS, Grace AA, Hariri AR, Harrison PJ, Hiroi N, Kenny PJ, Kleinman JE, Krystal AD, Lewis DA, Lipska BK, Marder SR, Mason GF, Mathalon DH, McClung CA, McDougle CJ, McIntosh AM, McMahon FJ, Mirnics K, Monteggia LM, Narendran R, Nestler EJ, Neumeister A, O'Donovan MC, Öngür D, Pariante CM, Paulus MP, Pearlson G, Phillips ML, Pine DS, Pizzagalli DA, Pletnikov MV, Ragland JD, Rapoport JL, Ressler KJ, Russo SJ, Sanacora G, Sawa A, Schatzberg AF, Shaham Y, Shamay-Tsoory SG, Sklar P, State MW, Stein MB, Strakowski SM, Taylor SF, Turecki G, Turetsky BI, Weissman MM, Zachariou V, Zarate CA Jr, Zubieta JK: Constance E. Lieber, Theodore R. Stanley, and the Enduring Impact of Philanthropy on Psychiatry Research. Biol Psychiatry. 2016 Jul 15. PMID: 27346079 Arnsten AF, Murray JD, Seo H, Lee D: Ketamine's Antidepressant Actions: Potential Mechanisms in the Primate Medial Prefrontal Circuits That Represent Aversive Experience. Biol Psychiatry. 2016 May 1. PMID: 27079495