Anderson, Karen S - Yale University - Biological & Biomedical Sciences

个人简介

Individuals infected with HIV have a substantially higher risk of developing cancer compared with uninfected people of the same age. The Anderson laboratory is involved in developing new antiviral therapies to treat HIV infections. A major focus is HIV reverse transcriptase, a viral polymerase essential for HIV replication PhD Ohio State University (1982) Senior Research Specialist Biorational Herbicide Design, Monsanto Co.

研究领域

Molecular Biology; Pharmacology; Anti-Retroviral Agents; HIV Reverse Transcriptase; Multifunctional Enzymes

近期论文

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Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry Li Z, Song F, Zhuang Z, Dunaway-Mariano D, Anderson KS. Monitoring enzyme catalysis in the multimeric state: direct observation of Arthrobacter 4-hydroxybenzoyl-coenzyme A thioesterase catalytic complexes using time-resolved electrospray ionization mass spectrometry. Anal Biochem. 2009 Jul 25. [Epub ahead of print] PMID: 19635449 [PubMed - as supplied by publisher] Identification of a beta3-peptide HIV fusion inhibitor with improved potency in live cells Bautista AD, Stephens OM, Wang L, Domaoal RA, Anderson KS, Schepartz A. Identification of a beta3-peptide HIV fusion inhibitor with improved potency in live cells. Bioorg Med Chem Lett. 2009 Jul 15;19(14):3736-8. Epub 2009 May 15. PMID: 19497744 [PubMed - in process] Discovery of wild-type and Y181C mutant non-nucleoside HIV-1 reverse transcriptase inhibitors using virtual screening with multiple protein structures. Nichols SE, Domaoal RA, Thakur VV, Tirado-Rives J, Anderson KS, Jorgensen WL. Discovery of wild-type and Y181C mutant non-nucleoside HIV-1 reverse transcriptase inhibitors using virtual screening with multiple protein structures. J Chem Inf Model. 2009 May;49(5):1272-9. PMID: 19374380 [PubMed - indexed for MEDLINE] Autophosphorylation of the kinase domain of FGFR1 is mediated by a sequential and precisely ordered reaction Furdui, C., Lew, E., Schlessinger, J., and Anderson, K.S. (2006). Autophosphorylation of the kinase domain of FGFR1 is mediated by a sequential and precisely ordered reaction. Molec. Cell 21:711-717 Modulation of HIV-1 synergistic inhibition by reverse transcriptase mutations Basavapathruni, A., et al. (2006). Modulation of HIV-1 synergistic inhibition by reverse transcriptase mutations. Biochem. 45:7334-40. Panaccione A, Zhang Y, Ryan M, Moskaluk CA, Anderson KS, Yarbrough WG, Ivanov SV: MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma. Stem Cell Res. 2017 May 5; 2017 May 5. PMID: 28500913 Kudalkar SN, Beloor J, Chan AH, Lee WG, Jorgensen WL, Kumar P, Anderson KS: Structural and Preclinical Studies of Computationally Designed Non-Nucleoside Reverse Transcriptase Inhibitors for Treating HIV infection. Mol Pharmacol. 2017 Apr; 2017 Feb 6. PMID: 28167742 Anderson KS: Understanding the molecular mechanism of substrate channeling and domain communication in protozoal bifunctional TS-DHFR. Protein Eng Des Sel. 2017 Mar 1. PMID: 28338744 Lee WG, Chan AH, Spasov KA, Anderson KS, Jorgensen WL: Design, Conformation, and Crystallography of 2-Naphthyl Phenyl Ethers as Potent Anti-HIV Agents. ACS Med Chem Lett. 2016 Dec 8; 2016 Oct 31. PMID: 27994756 Li M, Mislak AC, Foli Y, Agbosu E, Bose V, Bhandari S, Szymanski MR, Shumate CK, Yin YW, Anderson KS, Paintsil E: The DNA Polymerase Gamma R953C Mutant Is Associated with Antiretroviral Therapy-Induced Mitochondrial Toxicity. Antimicrob Agents Chemother. 2016 Sep; 2016 Aug 22. PMID: 27381400 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P: Data publication with the structural biology data grid supports live analysis. Nat Commun. 2016 Mar 7; 2016 Mar 7. PMID: 26947396 Mislak AC, Anderson KS: Insights into the Molecular Mechanism of Polymerization and Nucleoside Reverse Transcriptase Inhibitor Incorporation by Human PrimPol. Antimicrob Agents Chemother. 2015 Nov 9; 2015 Nov 9. PMID: 26552983 Lee WG, Frey KM, Gallardo-Macias R, Spasov KA, Chan AH, Anderson KS, Jorgensen WL: Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase. Bioorg Med Chem Lett. 2015 Nov 1; 2015 Jul 9. PMID: 26166629 Gray WT, Frey KM, Laskey SB, Mislak AC, Spasov KA, Lee WG, Bollini M, Siliciano RF, Jorgensen WL, Anderson KS: Potent Inhibitors Active against HIV Reverse Transcriptase with K101P, a Mutation Conferring Rilpivirine Resistance. ACS Med Chem Lett. 2015 Oct 8; 2015 Aug 31. PMID: 26487915 Sohl CD, Szymanski MR, Mislak AC, Shumate CK, Amiralaei S, Schinazi RF, Anderson KS, Yin YW: Probing the structural and molecular basis of nucleotide selectivity by human mitochondrial DNA polymerase γ. Proc Natl Acad Sci U S A. 2015 Jul 14; 2015 Jun 29. PMID: 26124101 Sohl CD, Ryan MR, Luo B, Frey KM, Anderson KS: Illuminating the molecular mechanisms of tyrosine kinase inhibitor resistance for the FGFR1 gatekeeper mutation: the Achilles' heel of targeted therapy. ACS Chem Biol. 2015 May 15; 2015 Feb 24. PMID: 25686244 Kim Y, Apetri M, Luo B, Settleman JE, Anderson KS: Differential Effects of Tyrosine Kinase Inhibitors on Normal and Oncogenic EGFR Signaling and Downstream Effectors. Mol Cancer Res. 2015 Apr; 2015 Jan 8. PMID: 25573954 Frey KM, Puleo DE, Spasov KA, Bollini M, Jorgensen WL, Anderson KS: Structure-based evaluation of non-nucleoside inhibitors with improved potency and solubility that target HIV reverse transcriptase variants. J Med Chem. 2015 Mar 26; 2015 Mar 5. PMID: 25700160 Mukerjee A, Iyidogan P, Castellanos-Gonzalez A, Cisneros JA, Czyzyk D, Ranjan AP, Jorgensen WL, White AC Jr, Vishwanatha JK, Anderson KS: A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium. Bioorg Med Chem Lett. 2015; 2015 Apr 4. PMID: 25900220 Iyidogan P, Anderson KS: Recent findings on the mechanisms involved in tenofovir resistance. Antivir Chem Chemother. 2014 Dec 16; 2014 Dec 16. PMID: 23744599