Aksoy, Serap - Yale University - Biological & Biomedical Sciences

个人简介

Serap Aksoy, PhD, came to Yale as a postdoctoral fellow in 1982 and worked her way to Professor in 2002. From 2002-2010, she headed the Division of Epidemiology of Microbial Diseases. She serves as editor in Chief of the journal PLoS Neglected Tropical Diseases and chaired both the NIH/NIAID Vector Biology Study Section (2010-2012) and the WHO/TDR, Molecular Entomology BL5 (2008-2012). Dr. Aksoy's lab aims to understand the biology of host-pathogen interactions--in particular in tsetse flies, which transmit African trypanosomes and harbor multiple symbiotic microbes. A graduate of Vassar College (BA) and Columbia University (PhD), Dr. Aksoy has lectured around the world, and maintains ongoing collaborative research programs with the National Livestock Research Institute (NaLIRRI) and Gulu University in Uganda, and Biotechnology Research Institute (BRI) in Kenya. The laboratory at Yale focuses on the development of novel methods to ultimately reduce tsetse populations in the field, or to reduce their ability to transmit disease. Studies in Uganda focus on the epidemiology of Sleeping Sickness disease. Together with BRI and her colleagues at Yale, Dr. Aksoy has been involved in an international training program to expand research capacity in tsetse-transmitted diseases in east Africa. As the EIC of PLOS NTDs, she works to build research and publication capacity for global neglected tropical diseases. PhD Columbia University (1982)

研究领域

Trypanosomiasis, African; Tsetse Flies; Global Health

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host. Toh H, et al. (2006) Massive genome erosion and functional adaptations provide insights into the symbiotic lifestyle of Sodalis glossinidius in the tsetse host. Genome research 16(2):149-156. An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein A Weiss BL, Wu Y, Schwank JJ, Tolwinski NS, & Aksoy S (2008) An insect symbiosis is influenced by bacterium-specific polymorphisms in outer-membrane protein A. Proc Natl Acad Sci U S A 105(39):15088-15093. Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Wang J, Wu Y, Yang G, & Aksoy S (2009) Interactions between mutualist Wigglesworthia and tsetse peptidoglycan recognition protein (PGRP-LB) influence trypanosome transmission. Proc Natl Acad Sci U S A 106(29):12133-12138 Tsetse immune system maturation requires the presence of obligate symbionts in larvae. Weiss BL, Wang J, & Aksoy S (2011) Tsetse immune system maturation requires the presence of obligate symbionts in larvae. PLoS biology 9(5):e1000619. Wolbachia symbiont infections induce strong cytoplasmic incompatibility in the tsetse fly Glossina morsitans. Alam U., Medlock J, Brelsfoard C, Pais R, Lohs C, Balmand S, Carnogursky J, Heddi A, Takac P, Galvani A, Aksoy S. Wolbachia symbiont infections induce strong cytoplasmic incompatibility in the tsetse fly Glossina morsitans. PLoS Pathog 2011; 7(12): e1002415 Obligate symbionts activate immune system development in the tsetse fly. Weiss BL, Maltz M, & Aksoy S (2012) Obligate symbionts activate immune system development in the tsetse fly. Journal of immunology 188(7):3395-3403. PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse's offspring. Wang J & Aksoy S (2012) PGRP-LB is a maternally transmitted immune milk protein that influences symbiosis and parasitism in tsetse's offspring. Proc Natl Acad Sci U S A 109(26):10552-10557). Insight into the transmission biology and species-specific functional capabilities of tsetse Rio, RV Symula RE, Wang J, Lohs C, Wu YN, Snyder AK, Bjornson RD, Oshima K, Biehl BS, Perna NT, Hattori M, Aksoy S. (2012) Insight into the transmission biology and species-specific functional capabilities of tsetse (Diptera: Glossinidae) obligate symbiont Wigglesworthia. MBio. 2012 Feb 14;3(1). pii: e00240-11 Opiro R, Saarman NP, Echodu R, Opiyo EA, Dion K, Halyard A, Dunn AW, Aksoy S, Caccone A: Genetic diversity and population structure of the tsetse fly Glossina fuscipes fuscipes (Diptera: Glossinidae) in Northern Uganda: Implications for vector control. PLoS Negl Trop Dis. 2017 Apr; 2017 Apr 28. PMID: 28453513 Aksoy S, Buscher P, Lehane M, Solano P, Van Den Abbeele J: Human African trypanosomiasis control: Achievements and challenges. PLoS Negl Trop Dis. 2017 Apr; 2017 Apr 20. PMID: 28426685 Hotez P, Aksoy S: PLOS Neglected Tropical Diseases: Ten years of progress in neglected tropical disease control and elimination … More or less. PLoS Negl Trop Dis. 2017 Apr; 2017 Apr 20. PMID: 28426662 Hotez PJ, Aksoy S: Will a new 2017 global leadership commit to NTDs? PLoS Negl Trop Dis. 2017 Mar; 2017 Mar 23. PMID: 28333927 Benoit JB, Vigneron A, Broderick NA, Wu Y, Sun JS, Carlson JR, Aksoy S, Weiss BL: Symbiont-induced odorant binding proteins mediate insect host hematopoiesis. Elife. 2017 Jan 12; 2017 Jan 12. PMID: 28079523 Savage AF, Kolev NG, Franklin JB, Vigneron A, Aksoy S, Tschudi C: Transcriptome Profiling of Trypanosoma brucei Development in the Tsetse Fly Vector Glossina morsitans. PLoS One. 2016; 2016 Dec 21. PMID: 28002435 Inci A, Yildirim A, Duzlu O, Doganay M, Aksoy S: Tick-Borne Diseases in Turkey: A Review Based on One Health Perspective. PLoS Negl Trop Dis. 2016 Dec; 2016 Dec 15. PMID: 27977689 Aksoy E, Vigneron A, Bing X, Zhao X, O'Neill M, Wu YN, Bangs JD, Weiss BL, Aksoy S: Mammalian African trypanosome VSG coat enhances tsetse's vector competence. Proc Natl Acad Sci U S A. 2016 Jun 21; 2016 May 16. PMID: 27185908 Gloria-Soria A, Dunn WA, Telleria EL, Evans BR, Okedi L, Echodu R, Warren WC, Montague MJ, Aksoy S, Caccone A: Patterns of Genome-Wide Variation in Glossina fuscipes fuscipes Tsetse Flies from Uganda. G3 (Bethesda). 2016 Jun 1; 2016 Jun 1. PMID: 27172181