Latham, John - University of Denver - Department of Chemistry & Biochemistry

研究领域

Our group is interested in understanding the structure-function relationship of radical-S-adenosylmethionine proteins that are used to modify small peptides found in ribosomally synthesized post-translationally modified peptide pathways. Once things get settled down, we'll provide you some more information. If you are really interested in knowing what we are working on behind our smoke screen, please feel free to contact the PI. We are always looking for collaborators and are always looking to help out fellow researchers.

近期论文

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Khaliullin, B., Aggarwal, P., Bubas, M., Eaton, G.R., Eaton, S.S., and Latham J.A. Mycofactocin biosynthesis: Modification of the peptide MftA by the radical S-adenosylmethionine protein MftC. FEBS Letters, 2016, 590, 2538-2548 1H, 13C, and 15N resonance assignments and secondary structure information for Methylobacterium extorquens PqqD and teh complex PqqD with PqqA. Biomol. NMR Assign., 2016, 10, 385-389. Barr, I., Latham, J.A., Iavarone, A.T., Chantarojsiri, T., Hwang, J.D., and Klinman, J. The pyrroloquinoline quinone (PQQ) biosynthetic pathway: Demonstration of de novo carbon-carbon cross-linking within the peptide substrate (PqqA) in the presence of the Radical SAM enzyme (PqqE) and its peptide chaperone (PqqD). JBC, 2016, 291, 8877-8884. Lim, S.K., Lee, W.S., Kim, Y.I., Sohn, Y., Cho, D.W., Kim, C. Kim, E., Latham, J.A., Dunaway-Mariano, D., Mariano, P.S. Photochemical and enzymatic SET promoted C–C bond cleavage reactions of lignin β-1 model compounds containing varying number of methoxy substituents on their arene rings. Tetrahedron, 2015, 71, 4236-4247 Latham, J.A., Iavarone, A.T., Barr, I., Juthani, P.V., and Klinman, J.P. PqqD is a novel peptide chaperone that forms a ternary complex with the radical S-adenosylmethionine protein PqqE in the pyrroloquinoline quinone biosynthetic pathway. JBC, 2015, 290, 12908-12918 Latham, J.A., Chen, D., Allen, K.N., and Dunaway-Mariano, D. Divergence of Substrate Specificity in the Escherichia coli. Hotdog-fold Thioesterase Paralogs YdiI and YbdB. Biochemistry, 2014, 53 4775-4787 (Wu, R., Latham, J. A.), Chen, D., Farelli, J., Zhao, H., Matthews, K., Allen, K.N., and Dunaway-Mariano, D. Structure and Catalysis in the Escherichia coli Hotdog-fold Thioesterase Paralogs YdiI and YbdB. Biochemistry, 2014, 53 4788-47805 Lim S.H., Nahm K., Ra C.S., Cho D.W., Yoon U.C., Latham J.A., Dunaway-Mariano D., and Mariano P.S. Effects of alkoxy groups on arene rings of lignin β-O-4 model compounds on the efficiencies of single electron transfer-promoted photochemical and enzymatic C-C Bond Cleavage Reactions. Journal of Organic Chemistry, 2013, 78, 9431-43. Chen D., Latham, J., Zhao, H., Bisoffi, M., Farelli, J., and Dunaway-Mariano, D. Human Brown Fat Inducible Thioesterase Variant 2 (BFIT2) Cellular Localization and Catalytic Function. Biochemistry, 2012, 51, 6990-9. Song, F., Thoden, J., Zhuang, Z., Latham, J., Trujillo, M., Holden, H., Dunaway-Mariano, D. The Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily Arthrobacter sp. strain SU 4-Hydroxybenzoyl-CoA Thioesterase. Biochemistry, 2012, 51, 7000-16. Zhao H., Lim K., Choudry A., Latham J.A., Dominguez D., Chandra M., Luo L., Herzberg O. and Dunaway-Mariano, D. Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. Biochemistry, 2012, 51, 6490-2. Zhuang Z., Latham J., Song F., Zheng W., Trujillo M., and Dunaway-Mariano D. Investigation of the Catalytic Mechanism of the Hotdog-fold Enzyme Superfamily Pseudomonas sp. strain CBS3 4-Hydroxybenzoyl-CoA Thioesterase. Biochemistry, 2012, 51, 786-794. Cho D.W., Latham J.A., Park H.J., Yoon U.C., Langan P., Dunaway-Mariano D., and Mariano P. Regioselectivity of enzymatic and photochemical single electron transfer promoted carbon-carbon bond fragmentation reactions of tetrameric lignin model compounds. J. Org. Chem., 2011, 76, 2840-52.