Kallan, Nicholas - Loretto Heights College

个人简介

Regis University: Assistant Professor of Chemistry (2012-present) Regis University: Adjunct Professor of Chemistry 2011/2012 academic year Array BioPharma, Inc., Discovery Chemistry, Medicinal Chemist 2002-2011 Ph.D. University of Colorado, Boulder 2002 B.S. Chemistry with Honors, Cum Laude, Davidson College, North Carolina 1996

研究领域

Generation of new organic synthesis methodologies Synthesis of molecules for validation of novel biological targets Utilization of medicinal chemistry principles to modify structures of biologically active molecules as potential drug leads

近期论文

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“Discovery and SAR of spirochromane Akt inhibitors” Kallan, Nicholas C.; Spencer, Keith L.; Blake, James F.; Xu, Rui; Heizer, Justin; Bencsik, Josef R.; Mitchell, Ian S.; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Gross, Stefan D.; Morales, Tony H.; Wu, Wen-I; Vigers, Guy P.A.; Brandhuber, Barbara J.; Skelton, Nicholas J. Bioorg. Med. Chem. Lett. 2011, 21(8), 2410. “Discovery of Spirocyclic Sulfonamides as Potent AKT Inhibitors with Exquisite Selectivity against PKA” Xu, Rui; Banka, Anna; Blake, James F.; Mitchell, Ian S.; Wallace, Eli M.; Bencsik, Josef R.; Kallan, Nicholas C.; Spencer, Keith L.; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Gross, Stefan D.; Morales, Tony H.; Wu, Wen-I; Vigers, Guy P.A.; Brandhuber, Barbara J.; Skelton, Nicholas J. Bioorg. Med. Chem. Lett. 2011, 21(8), 2335. “Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors” Bencsik, Josef R.; Xiao, Dengming; Blake, James F.; Kallan, Nicholas C.; Mitchell, Ian S.; Spencer, Keith L.; Xu, Rui; Gloor, Susan L.; Martinson, Matthew; Risom, Tyler; Woessner, Richard D.; Dizon, Faith; Wu, Wen-I.; Vigers, Guy P. A.; Brandhuber, Barbara J.; Skelton, Nicholas J.; Prior, Wei Wei; Murray, Lesley J. Bioorg. Med. Chem. Lett. 2010, 20(23), 7037. “Discovery of pyrrolopyrimidine inhibitors of Akt” Blake, James F.; Kallan, Nicholas C.; Xiao, Dengming; Xu, Rui; Bencsik, Josef R.; Skelton, Nicholas J.; Spencer, Keith L.; Mitchell, Ian S.; Woessner, Richard D.; Gloor, Susan L.; Risom, Tyler; Gross, Stefan D.; Martinson, Matthew; Morales, Tony H.; Vigers, Guy P. A.; Brandhuber, Barbara J. Bioorg. Med. Chem. Lett. 2010, 20(19), 5607. “Evolution of Akt Inhibitors for the Treatment of Cancer: From an HTS Hit to In Vivo Proof of Concept” Nicholas C. Kallan. University of Colorado Health Sciences Center Structural Biology and Biophysics Program Seminar, February 24, 2010.