Ahrendt, Kateri - Loretto Heights College

个人简介

Ph.D., 2003, University of California, Berkeley B.S., 1998, St. Cloud State University, Minnesota Reviewer for European Journal of Medicinal Chemistry, 2012 Session Chair at Gordon Research Conference in Medicinal Chemistry, Late Breaking Topics Session 2007 American Chemical Society National, Organic and Medicinal Chemistry Divisions, 1997-present

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Ren, L.; Ahrendt, K.A.; Grina, J.; Laird, E.R.; Buckmelter, A.J.; Hansen, J.D.; Newhouse, B.; Moreno, D.; Wenglowsky, S.; Dinkel, V.; Gloor, S.L.; Hastings, G.; Rana, S.; Rasor, K.; Risom, T.; Sturgis, H.L.; Voegtli, W.C.; Mathieu, S. The Discovery of Potent and Selective Pyridopyrimidin-7-one Based Inhibitors of B-RafV600E Kinase. Bioorg. Med. Chem. Lett. 2012, 22, 3387-3391. Wenglowsky, S.; Moreno, D.; Rudolph, J.; Ran, Y.; Ahrendt, K.A.; Arrigo, A.; Colson, B.; Gloor, S.L.; Hastings, G. Pyrazolopyridine Inhibitors of B-RafV600E. Part 3: An Increase in Aqueous Solubility via the Disruption of Crystal Packing. Bioorg. Med. Chem. Lett. 2012, 22, 912-915. Wenglowsky, S.; Ahrendt, K.A.; Buckmelter, A.J.; Feng, B.; Gloor, S.L.; Gradl, S.; Grina, J.; Hansen, J.D.; Laird, E.R.; Lunghofer, P.; Mathieu, S.; Moreno, D.; Newhouse, B.; Ren, L.; Risom, T.; Rudolph, J.; Seo, J.;Sturgis, H.L.; Voegtli, W.C.; Wen, Z. Pyrazolopyridine Inhibitors of B-RafV600E. Part 2: Structure- Activity Relationships. Bioorg. Med. Chem. Lett. 2011, 21, 5533-5537. Wenglowsky, S.; Ren, L.; Ahrendt, K.A.; Laird, E.R.; Aliagas, I.; Alicke, B.; Buckmelter, A.J.; Choo, E. F.;Dinkel, V.; Feng, B.; Gloor, S.L.; Gould, S. E.; Gross, S.; Gunzner-Toste, J.; Hansen, J.D.; Hatzivassiliou,G.; Liu, B.; Malesky, K.; Mathieu, S.; Newhouse, B.; Raddatz, N.J.; Ran, Y.; Rana, S.; Randolph, N.; Risom,T.; Rudolph, J.; Savage, S.; Selby, L.T.; Shrag, M.; Song, K.; Sturgis, H.L.; Voegtli, W.C.; Wen, Z.; Willis,B.S.; Woessner, R.D.; Wu, W.-I.; Young, W.B.; Grina, J. Pyrazolopyridine Inhibitors of B-RafV600E. :Part 1:The Development of Selective, Orally Bioavailable, and Efficacious Inhibitors. ACS Med. Chem. Lett. 2011,2, 342-347. Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Newhouse, B.; Ren, L.; Wenglowsky, S. M.; Feng, B.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.; Moreno, D.A. N-(6-Aminopyridin-3-yl)-3-(Sulfonamide)Benzamide Derivatives as B-Raf Inhibitors for the Treatment of Cancer and Their Preparation. PCT Int. Appl. (2009) WO 2009111280. Ahrendt, K. A.; Buckmelter, A. J..; De Meese, J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Lunghofer, P.; Moreno, D.; Newhouse, B.; Ren, L.; Seo, J.; Tian, H.; Wenglowsky, S. M.; Feng, B.; Gunzner, J.; Malesky,K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B. N-Pyrazolo[3,4-]pyridinyl Benzamide Derivatives as Raf Inhibitors and Their Preparation, Pharmaceutical Compositions and Use in the Treatment of Diseases. PCT Int. Appl. (2009) WO 2009111279. Kateri Ann Ahrendt, Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Moreno, D.; Newhouse, B.; Ren, L.;Wenglowsky, S. M.; Feng, B.; Gunzner, J.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.N-Pyrrolo[2,3-]pyridinyl Benzamide Derivatives as Raf Inhibitors and Their Preparation, PharmaceuticalCompositions and Use in the Treatment of Disease. PCT Int. Appl. (2009) WO 2009111278. Ahrendt, K. A.; Buckmelter, A. J.; Grina, J.; Hansen, J. D.; Laird, E. R.; Newhouse, B.; Ren, L.;Wenglowsky, S. M.; Feng, B.; Malesky, K.; Mathieu, S.; Rudolph, J.; Wen, Z.; Young, W. B.; Moreno, D.A. Imidazo[4,5-]pyridine Derivatives as Raf Inhibitors and Their Preparation and use in the Treatment of Diseases. PCT Int. Appl. (2009) WO 2009111277. Ahrendt, K. A.; Delisle, R. K.; Hans, J.; Lyssikatos, J. P.; Robinson, J. E.; Wallace, E. M.; Zhao, Q. Preparation of Difluorophenylcarbonylphenyldihydrothiadiazole Derivatives for Use as Mitotic Kinesin Inhibitors. PCT Int. Appl. (2008) WO 2008042928. Thalji, R. K.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A. Annulation of Aromatic Imines via Directed CHBond Activation. J. Org. Chem. 2005, 70, 6775. Ahrendt, K. A; Williams, R. M. A Concise Asymmetric Synthesis of the ADE Fragment of Nakadomarin A.Org. Lett. 2004, 6, 4539. Ahrendt, K. A.; Bergman, R. G.; Ellman, J. E. Synthesis of a Tricyclic Mescaline Analogue by Catalytic CHBond Activation. Org. Lett. 2003, 5, 1301. Ahrendt, K. A.; Olsen, J. A.; Wakao, M.; Trias, J.; Ellman, J. A. Identification of Potent and Broad Spectrum Antibiotics from SAR Studies of a Synthetic Vancomycin Analogue. Bioorg. Med. Chem. Lett. 2003, 13, 1683. Thalji, R. K.; Ahrendt, K. A.; Bergman, R. G.; Ellman, J. A. Annulation of Aromatic Imines via Directed CH Activation with Wilkinson's Catalyst. J. Am. Chem. Soc. 2001, 123, 9692. MacMillan, D. W. C.; Ahrendt, K. A. Chemical Synthesis Using Nonmetallic Organic Catalyst Compositions. PCT Int. Appl. (2001) WO 2001053241. MacMillan, D. W. C.; Ahrendt, K. A. Preparation of Imidazolidinone Acid Salts as Reaction Catalysts. PCT Int. Appl. (2001) WO 2001053269. Ahrendt, K. A.; Borths, C. J.; MacMillan, D. W. C. New Strategies for Organic Catalysis: The First Highly Enantioselective Organocatalytic Diels-Alder Reaction. J. Am. Chem. Soc. 2000, 122, 4243. Fischer, P. J.; Ahrendt, K. A.; Young, V. G., Jr.; Ellis, J. E. Trityltitanium Complexes. X-ray Structural Characterization of [Ti(CO)4{5-C(4-C6H4R)3}]- (R = H, OCH3). Organometallics 1998, 17, 13.