Malarkey, Chris - Loretto Heights College

个人简介

Ph.D., Biochemistry, Loyola University Chicago, 2008 B.S., Chemistry, Loyola University Chicago, 2003 My teaching style focuses on a discussion based classroom environment where students are actively engaged in the subject matter. I feel this teaching style made me a natural fit for the Team Based Learning method employed in the School of Pharmacy at Regis University. While in the classroom, I encourage students to look at the underlying assumptions for a particular theory that we may be working on. For example, when teaching protein/ligand binding, I ask students what are the assumptions made by a lock and key mechanism versus an induced fit model? I like to make the students aware that there are several ways of thinking about the same phenomenon. I encourage openly asking questions in my classroom as well, and I feel that this helps generate dialogue between students and therefore encourages them to critically examine key concepts in the physical sciences. In addition to teaching in the classroom, I am passionate about teaching and learning in the laboratory. I feel that the lab is where the frontiers of pharmaceutical sciences are advanced and new knowledge about disease states is obtained. Furthermore, I believe that the making discoveries in the laboratory help further the Regis University mission of the pursuit of truth. Before teaching at Regis University, I taught biochemical concepts to first year graduate students and medical students during my postdoctoral fellowship at the University of Colorado School of Medicine. During my graduate studies in chemistry, I taught general chemistry, organic chemistry, physical chemistry, and biochemistry to both undergraduate and graduate students.

研究领域

Information Theory: How do drugs interact with proteins? Bipolar Disorder: How does lithium serve as an effective therapeutic? Heart Disease: How does a mitochondrial transcription factor mutant lead to cardiomyopathies? Mitochondrial Transcription: Several disease states have altered mitochondrial transcription. Developing Autoimmune Disease Treatments: Autoimmune diseases such as lupus recognize “self” DNA as foreign pathogens. Can we exploit existing DNA binding proteins in the body as therapeutic agents? Testicular Cancer: Can we target the HMGB4/DNA interaction in chemotherapy? Understanding the Sox2/Promoter DNA mechanism: Several development diseases and cancer are associated with malfunctioning Sox2 function. Developing a greater understanding of this interaction at the molecular level could lead to novel therapeutics.

近期论文

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Malarkey, C.S., Gustafson, C.E., Saifee, J.F., Torres, R.M., Churchill, M.E.A., and Janoff, E.N. (2016) “Mechanism of mitochondrial transcription factor A attenuation of CpG-induced antibody production.” PloS one. 11. E0157157. Malarkey, CS, Lionetti, C, Deceglie, S, Roberti, M, Churchill, ME, Cantatore, P, Loguercio, P, Polosa, P (2016). The sea urchin mitochondrial transcription factor A binds and bends DNA efficiently despite its unusually short C-terminal tail. Mitochondrion. Apr 14;29:1-6. doi: 10.1016/j.mito.2016.04.004. [Epub ahead of print]. Sánchez-Giraldo, R., Acosta-Reyes, F.J., Malarkey, C.S., Saperas, N., Churchill, M.E.A., and Campos, J.L. (2015) “Two High-Mobility Group Box Domains Act Together to Underwind and Kink DNA.” Acta Crystallographica Section D. 71. 1423-1432. Das, C., Roy, S., Namshoshi, S., Malarkey, C.S., Jones, D.N.M., Kutateladze, T.G., Churchill, M.E.A., and Tyler, J.K. (2014) “Binding of the histone chaperone ASF1 to the CBP bromodomain promotes histone acetylation.” Proceedings of the National Academy of Sciences. 111, E1072-E1081. Wysoczynski, C.L., Roemer, S.C., Dostal, V., Barkley, R.M., Churchill, M.E.A., and Malarkey, C.S. (2013) “Reversed-phase Ion-pair Liquid Chromatography Method for Purification of Duplex DNA with Single Base Pair Resolution.” Nucleic Acids Research. 41. e194-e194. Malarkey, C.S., and Churchill, M.E.A. (2012) “The High Mobility Group Box: the Ultimate Utility Player of a Cell.” Trends in Biochemical Sciences. 37. 553-562. Malarkey, C.S., Bestwick, M., Kuhlwilm, J., Shadel, G.S., and Churchill, M.E.A. (2012) “Transcriptional Activation by Mitochondrial Transcription Factor A Involves Preferential Distortion of Promoter DNA.” Nucleic Acids Research. 40. 614-62