Smith , Jeff - University of Southern Colorado

个人简介

B.S., Biology, B.A, Chemistry, University of Minnesota-Duluth. Ph.D., Biomedical Sciences/Neuroscience, University of New Mexico School of Medicine.

研究领域

The broader aim of my research group is to understand the cellular-molecular mechanisms that underlie nervous system function in health and neurodegenerative disease, and to elucidate pathways for pharmacologically based therapies for disease. We are particularly interested in Alzheimer’s disease, copper biology, and stroke. To facilitate these aims we investigate how intracellular signal transduction mechanisms can modulate the molecular functions of ion exchangers, neurotransmitter receptors, voltage gated ion channels, and metabolite transporters in brain cells and slices. We use electrophysiological, intracellular imaging, pharmacological, and molecular methods to investigate these topics. Our work is funded by the National Institutes of Health Academic Research Enhancement Award throught the National Institute of Neurological Disorders and Stroke.

近期论文

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Smith JP, Uhernik AL, Li L, Liu Z, Drewes LR. (2012). Regulation of Mct1 by cAMP-dependent internalization in rat brain endothelial cells. Brain Res. 1480: 1-11. Salazar-Weber NL, Smith JP. (2011). Copper Inhibits NMDA Receptor-Independent LTP and Modulates the Paired-Pulse Ratio after LTP in Mouse Hippocampal Slices. Int J Alzheimers Dis. 2011:864753. Uhernik AU, Tucker C, Smith JP (2011). Control of MCT1 function in cerebrovascular endothelial cells by intracellular pH. Brain Res. 1376:10-22. Smith JP, Lal V, Bowser D, Cappai R, Masters CL, Ciccotosto GD. (2009). Stimulus pattern dependence of the Alzheimer's disease amyloid-beta 42 peptide's inhibition of long term potentiation in mouse hippocampal slices. Brain Res. 1269:176-84. Ciccotosto GD, Tew DJ, Drew SC, Smith DG, Johanssen T, Lal V, Lau TL, Perez K, Curtain CC, Wade JD, Separovic F, Masters CL, Smith JP, Barnham KJ, Cappai R. (2009) Stereospecific interactions are necessary for Alzheimer disease amyloid-beta toxicity. Neurobiol Aging 1269:176-84. Adlard PA, Cherny RA, Finkelstein DI, Gautier E, Robb E, Cortes M, Volitakis I, Liu X, Smith JP, Perez K, Laughton K, Li QX, Charman SA, Nicolazzo JA, Wilkins S, Deleva K, Lynch T, Kok G, Ritchie CW, Tanzi RE, Cappai R, Masters CL, Barnham KJ, Bush AI. (2008). Rapid restoration of cognition in Alzheimer's transgenic mice with 8-hydroxy quinoline analogs is associated with decreased interstitial Abeta. Neuron 59(1):43-55. Barnham, K.J., V.B. Kenche, G.D. Ciccotosto, D.P. Smith, D.J. Tew, X. Liu, K. Perez, G.A. Cranston, T.J. Johanssen, I. Volitakis, A.I. Bush, C.L. Masters, A.R. White, J.P. Smith, R.A. Cherny and R.Cappai (2008) Platinum based inhibitors of amyloid-beta as therapeutic agents for Alzheimer's disease. PNAS 105(19):6813-8. Smith, J.P. and L.R. Drewes (2006) Modulation of MCT1 function by cAMP in rat brain endothelial cells. Journal of Biological Chemistry 281(4):2053-60. Gilbert, M., J. Smith, A.J. Roskams, and V.J. Auld (2001). Neuroligin 3 is a vertebrate gliotactin expressed in the olfactory ensheathing glia, a growth-promoting class of macroglia. Glia 34(3):151-64. Smith J.P., L.A. Cunningham, and L.D. Partridge (2000). Coupling of AMPA receptors with the Na+/Ca2+ exchanger in cultured rat astrocytes. Brain Research 887:98-109. Smith J.P., P.S. Hicks, L.R. Ortiz, M.J. Martinez, and R.N. Mandler (1995). Quantitative measurements of muscle strength in the mouse. Journal of Neuroscience Methods 62:15-19.