James, Andrea - University of Northern Colorado

个人简介

2015- 2016 Postdoctoral Research Fellow, University of Pittsburgh, Ophthalmology 2012- 2015 Postdoctoral Research Fellow, University Texas at Austin, Department of Molecular Biosciences 2005- 2011 PhD, Stanford University, Molecular and Cellular Physiology 2000-2005 Bachelor of Science, San Francisco State University, Biology Major with an emphasis in Cell and Molecular Biology, Chemistry and History minor

研究领域

The goal of my research is to determine how cell adhesion components contribute to choroid fissure closure (CFC-closure of the ventral eye), and, more specifically, how the adhesion proteins/complexes mediate intracellular signaling and subsequent regulation of cytoskeletal stability required for proper closure. Zebrafish offer a powerful model system through which the molecular and cellular underpinnings of CFC can be elucidated due to the diverse array of imaging, genetic and molecular tools available in the system. My previous research establishes a system through which discrete events during eye development can be dissected at the cellular and molecular level. My future research builds upon these studies, and focuses on dissecting the molecular underpinnings of tissue fusion in the choroid fissure

近期论文

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*James, A., *Lee, C., Williams, A., Angileri, K., Lathrop, K., and J. Gross. The Hyaloid Vasculature Facilitates Basement Membrane Breakdown during Choroid Fissure Closure in the Zebrafish Eye. Manuscript in review at Developmental Biology * Co-First Authors Hartsock, A., Lee, C., Arnold, V., and J. Gross. Hyaloid vasculature formation in zebrafish does not require the lens for recruitment of vascular precursor cells Developmental Biology, 394 (2), 327-39, 2014 *Hayes, J., *Hartsock, A., Clark, B., Napier, H., Link, B. and J. Gross. Integrin-alpha5/ Fibronectin and Focal adhesion Kinase are required for lens fiber morphogenesis in Zebrafish. Molecular Biology of the Cell. 23(24)4725-38, 2012 * Co-First Authors Hartsock, A., and W. James Nelson. Competitive Regulation of E-cadherin Degradation by p120-Catenin Binding and Hakai-Mediated Ubiquitination. PLoS ONE. 7(5) e37476, 2012 Hartsock, A., and W. James Nelson. Adherens and Tight Junctions: Structure, function, and connections to the actin cytoskeleton. BBA Biomembranes, 2008 Mar;1778 (3): 660-9.