Fox, Jerome M. - University of Colorado - Chemical and Biological Engineering

个人简介

Ph.D., University of California, Berkeley (2012) B.S., Johns Hopkins University (2007)

研究领域

The biological cell is, perhaps, the most impressive dissipative system found in nature. Operating far from equilibrium, the cell utilizes gradients in free energy to drive networks of chemical reactions that are staggeringly complex, yet tightly regulated in space and time. A detailed understanding of cellular function (and dysfunction) requires an understanding of the mechanisms by which individual reactions interact and organize themselves to sustain the higher-order biochemical processes (e.g. metabolism, cell division) that constitute cellular “life.” My group studies these mechanisms of interaction and organization (temporal and spatial) and uses them to interrogate, control, and rewire biochemical networks of relevance to human health, energy, and the environment.

近期论文

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Semenov SN, Kraft LJ, Ainla A, Zhao M, Baghbanzadeh M, Campbell VE, Kang K, Fox JM, and Whitesides GM (2016). Autocatalytic, bistable, oscillatory networks of biologically relevant organic reactions. Nature, 537 (7622), 656-660. Fox JM, Kang K, Lockett MR, Baghbanzadeh M, Sherman W, Héroux A, Sastry M, Whitesides GM (2015). Interactions between Hofmeister Anions and the Binding Pocket of a Protein. Journal of the American Chemical Society, 137 (11), 3859-3866. Fox JM and Whitesides GM (2015). Warning Signals for Eruptive Events in Spreading Fires. Proceedings of the National Academy of Sciences, 112 (8), 2378-2383. Nemiroski A, Gonidec M, Fox JM, Jean-Remy P, Turnage E, and Whitesides GM (2014). Engineering Shadows to Fabricate Optical Metasurfaces. ACS Nano, 8 (11), 11061-11070. Fox JM, Jess P, Jambusaria RB, Moo GM, Liphardt J, Clark DS, Blanch HW (2013). A Single-Molecule Analysis Reveals Morphological Targets for Cellulase Synergy. Nature Chemical Biology, 9 (6), 356-61. Fox JM, Levine SE, Clark DS, and Blanch HW (2012). Initial- and Processive-Cut Products Reveal Cellobiohydrolase Rate Limitations and Role of Companion Enzymes. Biochemistry, 51, 442-452. Levine SE, Fox JM, Blanch HW, and Clark DS (2010). A Mechanistic Kinetic Model of the Enzymatic Hydrolysis of Cellulose. Biotechnology and Bioengineering, 107, 37-51.