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研究领域

In our lab,We are studying relationship between structure and function of bio-macromolecules using Nuclear Magnetic Resonance (NMR), molecular biological techniques, and bioinformatics. In particular, we are interested in the mechanism of energy conversion and signal transduction in living systems.

近期论文

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Takai T., Takaya T., Nakano M., Akutsu H., Nakagawa A., Aimoto S., Nagai K., Ikegami T. Orexin-A is composed of a highly conserved C-terminal and a specific, Hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor. Journal of Peptide Science 12, 443-454. Nosaka A. Y., Nishino J., Fujiwara T., Ikegami T., Yagi H., Akutsu H., Nosaka Y. Effects of thermal treatments on the recovery of adsorbed water and photocatalytic activities of TiO2 photocatalytic Systems. Journal of Physical Chemistry B 110, 8380-8385. Saitoh T., Ikegami T., Nakayama M., Teshima K., Akutsu H.,Hase T. NMR Study of the Electron Transfer Complex of Plant Ferredoxin and Sulfite Reductase: Mapping the interaction sites of ferredoxin. Journal of Biological Chemistry 281, 10482-10488. Akagi K., Watanabe J., Hara M., Kezuka Y., Chikaishi E., Yamaguchi T., Akutsu H., Nonaka T., Watanabe T., Ikegami T. Identification of the substrate interaction region of the chitin- binding domain of Streptomyces griseus chitinase C. Journal of Biochemistry (Tokyo) 139, 483-493. Fujiwara T., Ramamoorthy A. “How Far Can the Sensitivity of NMR Be Increased?”. Annual Reports on NMR Spectroscopy 58, 159-180. Nakano T., Ikegami T., Suzuki T., Yoshida M., Akutsu H. A New Solution Structure of ATP Synthase Subunit c From Thermophilic Bacillus PS3, Suggesting a Local Conformational Change for H+-Translocation. Journal of Molecular Biology 358, 132-144. Takayama Y., Kobayashi Y., Yahata N., Saitoh T., Hori H., Ikegami T., Akutsu H. Specific Binding CO to Tetraheme Cytochrome c3. Biochemistry 45, 3163-3169. Yahata N., Saitoh T., Takayama Y., Ozawa K., Ogata H., Higuchi Y., Akutsu H. Redox Interaction of Cytochrome c3 with [NiFe] Hydrogenase from Desulfovibrio vulgaris Miyazaki F. Biochemistry 45, 1653-1662. Kim S.-M., Yamamoto T., Todokoro Y., Takayama Y., Fujiwara T., Akutsu H. Phospholipid-Dependent Regulation of Cytochrome c3-Mediated Electron Transport across Membranes. Biophysical Journal 90, 506-513. Umitsu M., Morishita H., Murata Y., Udaka K., Akutsu H., Yagi T., Ikegami T. 1H, 13C and 15N resonance assignment of the first cadherin domain of Cadherin-related neuronal receptor (CNR)/protocadherin a. Journal of Biomolecular NMR 31, 365-366. "

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