郭瑞鲜 - 中山大学 - 中山医学院

个人简介

副教授，硕士生导师。现为中山大学中山医学院生理教研室教师。2009年获得中山大学生理学博士学位；2011年12月晋升为副教授。2005.10-2006.10期间，在法国进行博士后研究工作，从事睡眠机制研究。近年来，主要从事吗啡镇痛耐受机制的研究。作为主持人已获得国家自然科学基金、广东省自然科学基金、广东省医学科学技术研究基金的资助；作为主要合作者参与了多项国家自然科学基金、广东省科技计划项目。近5年发表论文20余篇，其中第一作者或通讯作者7篇。

研究领域

主要从事吗啡镇痛耐受机制的研究。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Shen N, Mo LQ, Hu F, Chen PX, Guo RX, Feng JQ. A Novel Role of Spinal Astrocytic Connexin 43: Mediating Morphine Antinociceptive Tolerance by Activation of NMDA Receptors and Inhibition of Glutamate Transporter-1 in Rats. CNS Neurosci Ther. 2014, 20(8): 728-36. (共同通讯作者) 2. Guo RX, Anaclet C, Roberts JC, Parmentier R, Zhang M, Guidon G, Buda C, Sastre JP, Feng JQ, Franco P, Brown SH, Upton N, Medhurst AD, Lin JS. Differential effects of acute and repeat dosing with the H3 antagonist GSK189254 on the sleep-wake cycle and narcoleptic episodes in Ox-/- mice. Br J. Pharmacol. 2009, 159(1): 104-117. 3. Guo RX, Zhang M, Liu W, Zhao CM, Cui Y, Wang CH, Feng JQ, Chen PX . NMDA receptors are involved in upstream of the spinal JNK activation in morphine antinociceptive tolerance. Neurosci Lett. 2009, 467(2): 95-9. 4. Zhao CM, Guo RX, Hu F, Meng JL, Mo LQ, Chen PX, Liao XX, Cui Y, Feng JQ. Spinal MCP-1 Contributes to the Development of Morphine Antinociceptive Tolerance in Rats. Am J Med Sci. 2012, 344(6): 473-9. 5. Zhang M, Guo RX, Mo LQ, Liao XX, Li W, Zhi JL, Sun SN, Wang YL, Cui Y, Liu W, Feng JQ, Chen PX. Nuclear factor-κB mediates cytoprotection of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress in PC 12 cells. Clin.Exp. Pharmaco.P. 2009, 36(3): 304-311. 6. Hu F, CUI Y, Guo RX, Chen JF, Guo RM, Shen N, Hua XX, Mo LQ, Feng JQ. Spinal leptin contributes to the development of morphine antinociceptive tolerance by activating the STAT3-NMDA receptor pathway in rats. Mol Med Rep. 2014, 10: 923-930. 7. Gondard E, Anaclet C, Akaoka H, Guo RX, Zhang M, Buda C, Franco P, Kotani H, Lin JS. Enhanced histaminergic neurotransmission and sleep-wake alterations, a study in histamine h3-receptor knock-out mice. Neuropsychopharmacology. 2013, 38(6):1015-31. 8. Chen SL, Yang CT, Yang ZL, Guo RX, Meng JL, Cui Y, Lan AP, Chen PX, Feng JQ. Hydrogen sulphide protects H9c2 cells against chemical hypoxia-induced injury. Clin.Exp. Pharmaco.P. 2010, 37(3): 316-321. 9. Cui Y, Liao XX, Liu W, Guo RX, Wu ZZ, Zhao CM, Chen PX, Feng JQ. A novel role of minocycline: attenuating morphine antinociceptive tolerance by inhibition of p38 MAPK in the activated spinal microglia. Brain Behav Immun. 2008, 22: 114-123. (Impact factor 4.909) 10. Cui Y, Chen Y, Zhi JL, Guo RX, Feng JQ, Chen PX. Activation of p38 mitogen-activated protein kinase in spinal microglia mediates morphine antinociceptive tolerance. Brain Res. 2006, 1069(1):235-43.