马明明 - 中山大学 - 中山医学院

个人简介

受教育经历： 2007/09-2012/06，中山大学，中山医学院，药理学博士； 2002/09-2007/06，中山大学，中山医学院，临床医学本科。研究工作经历： 2016/01-至今，中山大学，中山医学院，副教授； 2012/07-2015/12，中山大学，中山医学院，讲师。

研究领域

研究领域为心血管药理学，主要研究方向为Cl-通道与心血管疾病的关系研究，重点研究Cl-通道与高血压等心血管疾病发生发展的关系，从Cl-通道角度探讨心血管疾病的共同发病机制，寻找心血管疾病的干预靶标，发展新型抗心血管疾病药物。

近期论文

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1、TMEM16A contributes to endothelial dysfunction by facilitating Nox2 NADPH oxidase-derived reactive oxygen species generation in hypertension. Ming-Ming Ma#*, Min Gao#, Kai-Min Guo#, Mi Wang#, Xiang-Yu Li, Xue-Lin Zeng, Lu Sun, Xiao-Fei Lv, Yan-Hua Du, Guan-Lei Wang, Jia-Guo Zhou, Yong-Yuan Guan*. Hypertension. 2017;69(5):892-901. (JCR一区，IF=6.823, 第一及通讯作者) 2、Threonine532 phosphorylation in ClC-3 channels is required for angiotensin II-induced Cl- current and migration in cultured vascular smooth muscle cells. Ming-Ming Ma#, Cai-Xia Lin#, Can-Zhao Liu#, Min Gao, Lu Sun, Yong-Bo Tang, Jia-Guo Zhou, Guan-Lei Wang*, Yong-Yuan Guan*. Br J Pharmacol. 2016;173(3):529-44. (JCR一区，IF=5.491, 第一作者) 3、Simvastatin attenuated cerebrovascular cell proliferation in the development of hypertension through Rho/Rho-kinase pathway. Ming-Ming Ma#, Shi-Yang Li#, Mi Wang, Yong-Yuan Guan*. J Cardiovasc Pharmacol. 2012;59(6):576-82. (SCI收录，IF=2.383, 第一作者) 4、Transmembrane member 16A participates in hydrogen peroxide-induced apoptosis by facilitating mitochondria-dependent pathway in vascular smooth muscle cells. Jia-Wei Zeng#, Bao-Yi Chen#, Xiao-Fei Lv#, Lu Sun, Xue-Lin Zeng, Hua-Qing Zheng, Yan-Hua Du, Guan-Lei Wang, Ming-Ming Ma*, Yong-Yuan Guan*. Br J Pharmacol. 2018;175(18):3669-3684. (JCR一区，IF=6.810, 共同通讯作者) 5、Simvastatin attenuated rat thoracic aorta remodeling by decreasing ROCK2‑mediated CyPA secretion and CD147‑ERK1/2‑cyclin pathway. Fu-Cai Tang#, Hong-Yan Wang#, Ming-Ming Ma #, Tian-Wang Guan#, Long Pan, Dun-Chen Yao, Ya-Lan Chen, Sheng-Jie Li, Hang Yang, Xiao-Qin Zhu, Yong-Sheng Tu*. Mol Med Rep. 2017;16(6):8123-8129. (SCI收录，IF=1.922, 共同第一作者) 6、Endophilin A2 protects H2O2-induced apoptosis by blockade of Bax translocation in rat basilar artery smooth muscle cells. Yun Liu#, Min Gao#, Ming-Ming Ma #, Yong-Bo Tang, Jia-Guo Zhou, Guan-Lei Wang, Yan-Hua Du*, Yong-Yuan Guan*. J Mol Cell Cardiol. 2016;92:122-33. (JCR一区，，IF=5.680, 共同第一作者) 7、 TRPC3 channel confers cerebrovascular remodelling during hypertension via transactivation of EGF receptor signalling. Mi Wang#*, Yong-Bo Tang#, Ming-Ming Ma #, Jing-Hui Chen, Chang-Ping Hu, Shui-Ping Zhao, Dao-Quan Peng, Jia-Guo Zhou, Yong-Yuan Guan, Zheng Zhang*. Cardiovasc Res. 2016;109(1):34-43. (JCR一区，，IF=5.878, 共同第一作者) 8、 Integrin β3 mediates cerebrovascular remodelling through Src/ClC-3 volume-regulated Cl- channel signalling pathway. Jia-Wei Zeng#, Xiao-Guang Wang#, Ming-Ming Ma #, Xiao-Fei Lv, Jie Liu, Jia-Guo Zhou, Yong-Yuan Guan*. Br J Pharmacol. 2014;171(13):3158-70. (JCR一区，IF=4.842, 共同第一作者) 9、Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension. Ling-Yun Zheng#, Lei Li#, Ming-Ming Ma #, Yun Liu, Guan-Lei Wang, Yong-Bo Tang, Jia-Guo Zhou, Xiao-Fei Lv, Yan-Hua Du*, Yong-Yuan Guan*. Cardiovasc Res. 2013;100(1):134-42. (JCR一区，IF=5.808, 共同第一作者) 10、Tyrosine 284 phosphorylation is required for ClC-3 chloride channel activation in vascular smooth muscle cells. Xiao-Guang Wang#, Jing Tao#, Ming-Ming Ma #, Yong-Bo Tang, Jia-Guo Zhou, Yong-Yuan Guan*. Cardiovasc Res. 2013;98(3):469-78. (JCR一区，IF=5.808, 共同第一作者) 11、Mitochondria dependent pathway is involved in bestrophin-3 protective effect on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells. Lei Jiang#, Yun Liu#, Ming-Ming Ma #, Yong-Bo Tang, Jia-Guo Zhou, Yong-Yuan Guan*. Apoptosis. 2013;18(5):556-65. (SCI收录，IF=3.614, 共同第一作者)