陈丽君 - 中山大学 - 中山医学院

个人简介

1995年获中山医科大学药理学硕士学位；2002获中山大学医学博士学位。自1995以来一直在中山大学中山医学院药理学教研室（原中山医科大学药理教研室）工作，历任助教、讲师、副教授。2002-2004在美国波士顿大学医学院生化系完成博士后训练，任副研究员。2006年12月被中山大学聘为副教授。主持一项国家自然科学基金项目、一项教育部项目，参与多项省部级基金项目。

研究领域

（1）细胞分子药理学：赖氨酰氧化酶（lysyl oxidase, LO）的细胞、分子生物学基础，赖氨酰氧化酶与纤维化疾病的研究以及抗纤维化药物筛选。（2）从肿瘤细胞的诱导分化角度探讨实体肿瘤的治疗

近期论文

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1)Li W, Zhou J, Chen L, Luo Z, Zhao Y. Lysyl oxidase, a critical intra- and extra-cellular target in the lung for cigarette smoke pathogenesis. Int J Environ Res Public Health. 2011 Jan; 8(1):161-84. 2)Chen LJ, Li WD, Li SF, Su XW, Lin GY, Huang YJ, Yan GM. Bleomycin induces upregulation of lysyl oxidase in cultured human fetal lung fibroblasts. Acta Pharmacologica Sinica. 2010 May; 31(5): 554-559. 3)Lijun Chen, Shifeng Li, Xinwen Su, et al. Pulmonary toxicity of bleomycin involved in upregulation of lysyl oxidase activity in cultured human fetal lung fibroblasts. 16th World Congress on Basic and Clinical Pharmacology, 2010/07/17. 4)黎仕峰，罗森，扬小晓，*陈丽君特发性肺纤维化发病机制研究进展广东医学 2010/10；31（19）：pp2592-2594. 5)Zhao YZ, Chen LJ, Gao S, Toselli P, Stone P, and Li W. The critical role of the cellular thiol homeostasis in cadmium perturbation of the lung extracellular matrix. Toxicology 2010; 267:60~69. 6）Cao L, Cao DX, Su XW, Chen LJ, Liu AL, Jian WJ, Wu YP, Qiu PX, Yan GM. Activation of PI3-K/Akt pathway for thermal preconditioning to protect cultured cerebellar granule neurons against low potassium-induced apoptosis.Acta Pharmacol Sin. 2007 Feb; 28(2):173- 7) Chen LJ, Zhao YZ, Gao S, Chou IN, Toselli P, Stone P, and Li W. Downregulation of Lysyl Oxidase and Upregulation of Cellular Thiols in Rat Fetal Lung Fibroblasts Treated with Cigarette Smoke Condensate. Toxicol Sci. 2005 Feb; 83(2) : 372~379. 8)Gao S, Chen K, Zhao Y, Rich CB, Chen L, Li SJ, Toselli P, Stone P, Li W. Transcriptional and Posttranscriptional Inhibition of Lysyl Oxidase Expression by Cigarette Smoke Condensate in Cultured Rat Fetal Lung Fibroblasts. Toxicol Sci. 2005 Sep; 87(1): 197~203. 9)Chen LJ, Su XW, Qiu PX, Huang YJ, and Yan GM. Thermal preconditioning protected cerebellar granule neurons of rats by modulating HSP70 expression. Acta Pharmacol Sin. 2004 Apr; 25(4): 458~461. 10) Chen LJ, Su XW, Qiu PX, Yan GM, et al. Thermal Preconditioning Protects Rat Cerebellar Granule Neurons from Apoptosis Induced by Repolarization. Acad J SUMS. 2002; 23(1): 14~16, 26. 11) Chen LJ, Chen RZ. Subtypes of central nicotinic receptors involved in learning and memory. Acta Pharmacol Sin. 1999 Aug; 20(8): 725~728.