唐忠辉 - 中山大学 - 中山医学院

个人简介

唐忠辉博士在华中农业大学获得生物化学与分子生物博士学位，在新加坡基因组研究所和美国杰克逊实验室基因组医学中心完成博士后训练，博士后期间从事生物信息学大数据分析和算法开发。唐忠辉博士入选国家高层次海外引进人才项目（2017），建立“3D基因组结构与功能”的课题组。

研究领域

主要的研究方向为揭示染色质高级空间结构如何进行基因的表达调控，理解遗传变异破坏的染色质空间结构如何引起疾病的发生、发展。

近期论文

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Tang Z*, Luo OJ*, Li X*, Zheng M, Zhu JJ, Szalaj P, Trzaskoma P, Magalska A, Wlodarczyk J, Ruszczycki B, et al. (2015). CTCF-Mediated Human 3D Genome Architecture Reveals Chromatin Topology for Transcription. Cell 163: 1611-27 (*equal contribution). Kieffer-Kwon KR*, Tang Z*, Mathe E*, Qian J*, Sung MH*, Li G, Resch W, Baek S, Pruett N, Grøntved L, et al. (2013). Interactome Maps of Mouse Gene Regulatory Domains Reveal Basic Principles of Transcriptional Regulation. Cell 155: 1507-20. (*equal contribution, cover story). Szałaj P*, Tang Z*, Michalski P*, Piętal M*, Luo OJ, Li X, Ruan Y, Plewczynski D. (2016). An integrated 3-Dimensional Genome Modeling Engine for data-driven simulation of spatial genome organization. Genome Research 26: 1697-1709 (*equal contribution). Menghi F, Barthel FP, Yadav V, Tang M, Ji B, Tang Z, Carter GW, Ruan Y, Scully R, Verhaak RGW, Jonkers J, Liu ET. (2018). The tandem duplicator phenotype is a prevalent genome-wide cancer configuration driven by distinct gene mutations. Cancer Cell. 34(2):197-210. Vian L, Pękowska A, Rao SSP, Kieffer-Kwon KR, Jung S, Baranello L, Huang SC, El Khattabi L, Dose M, Pruett N, Sanborn AL, Canela A, Maman Y, Oksanen A, Resch W, Li X, Lee B, Kovalchuk AL, Tang Z, Nelson S, Di Pierro M, Cheng RR, Machol I, St Hilaire BG, Durand NC, Shamim MS, Stamenova EK, Onuchic JN, Ruan Y, Nussenzweig A, Levens D, Aiden EL, Casellas R. (2018). The Energetics and Physiological Impact of Cohesin Extrusion. Cell. 173(5):1165-1178.e20. Li P, Mitra S, Spolski R, Oh J, Liao W, Tang Z, Mo F, Li X, West EE, Gromer D, Lin JX, Liu C, Ruan Y, Leonard WJ. (2017). STAT5-mediated chromatin interactions in superenhancers activate IL-2 highly inducible genes: Functional dissection of the Il2ra gene locus. Proc Natl Acad Sci USA pii: 201714019. Li X, Luo OJ, Wang P, Zheng M, Wang D, Piecuch E, Zhu JJ, Tian SZ, Tang Z, Li G, Ruan Y. (2017). Long-read ChIA-PET for base-pair-resolution mapping of haplotype-specific chromatin interactions. Nature Protocols 12: 899-915. Szalaj P, Michalski PJ, Wróblewski P, Tang Z, Kadlof M, Mazzocco G, Ruan Y, Plewczynski D. (2016). 3D-GNOME: an integrated web service for structural modeling of the 3D genome. Nucleic Acids Res. 2016 May 16. pii: gkw437. Vahedi G, Kanno Y, Furumoto Y, Jiang K, Parker SC, Erdos MR, Davis SR, Roychoudhuri R, Restifo NP, Gadina M, Tang Z, Ruan Y, Collins FS, Sartorelli V, O'Shea JJ (2015). Super-enhancers delineate disease-associated regulatory nodes in T cells. Nature 520: 588-62. Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon KR, Resch W, Liang G, Tang Z, Mathé E, Benner C, et al. (2014). B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell 159: 1524-37.