吕志跃 - 中山大学 - 中山医学院

个人简介

医学博士，教授，博士导师，寄生虫学教研室主任，八年制医学生全程导师，广东省博士后理事会副理事长，广东省寄生虫学会秘书长，玛希隆大学（Mahidol University）客座教授。2005年于中南大学湘雅医学院获医学博士学位，2007年于中山大学中山医学院博士后出站并留校。近年来一直从事分子病原生物学、病原疫苗开发与药物研制、重要入侵病原快速溯源等领域的研究工作。主持国家重点研发项目课题、国家自然科学基金（3项）、广东省国际科技合作重点项目等15项课题，经费总额超过600万。在国内外专业学术期刊发表论文50余篇，其中SCI论文30余篇（通讯作者、第一作者20篇）。2010年赴德国马普分子遗传学研究所进行科研交流与合作。2012年被选拔为国家留学基金“青年骨干教师”赴美国韦恩州立大学医学院公派留学一年。主编、参编教材8部，主持3项教学改革项目（含1项重点项目）。指导学生3次获得“全国大学生基础医学创新论坛暨实验设计大赛”一等奖，并获国家大学生创新训练项目（2项）、广东省大学生创新训练项目及中山大学医科学生业余科研暨科研助理计划等项目资助。

研究领域

近年来一直从事分子病原生物学、病原疫苗开发与药物研制、重要入侵病原快速溯源等领域的研究工作。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Zhou HL, Chen Z, Limpanont Y, Hu Y, Ma YB, Huang P, Paron D, Zhou MY, Cheng YX, Lv ZY*. Necroptosis and caspase-2-mediated apoptosis of astrocytes and neurons, but not microglia, of rat hippocampus and parenchyma caused by Angiostrongylus cantonensis infection. Front Microbiol. 2020,10:3126. 2. Xu L, Xu M, Sun X, Xu JY, Zeng X, Shan D, Yuan DJ, He P, He WM, Yang YL, Luo SQ, Wei J, Wu XY, Liu Z, Xu XM, Dong ZS, Song LG, Zhang BB, Yu ZL, Wang LF, Zhang C, Fang XD, Gao Q*, Lv ZY*, Wu ZD*. The genetic basis of adaptive evolution in parasitic environment from the Angiostrongylus cantonensis genome. PLOS Neglect Trop D, 2019,13(11):e0007846. 3. Zhang HR, Wu YQ, Hu Y, Li XF*, Zhao MY*, Lv ZY*.Targeted nanoparticle drug delivery system for the enhancement of cancer immunotherapy. J Biomed Nanotechnol. 2019,15(9): 1839-1866. 4. Shen SS, Qu XY, Zhang WZ, Li J, Lv ZY *. Infection against infection: Parasite antagonism against parasites, viruses and bacteria. Infect Dis Poverty. 2019,8(1):49. 5. Hu Y, Gao MZ, Huang P, Zhou HL, Ma YB, Zhou MY, Cheng SY, Xie HG*, Lv ZY*.Taxonomic integrative and phylogenetic identification of the first recorded Triatoma rubrofasciata in Zhangzhou, Fujian Province and Maoming, Guangdong Province, China. Infect Dis Poverty. 2019, 8(1):70. 6. Deng MH, Zhong LY, Kamolnetr O, Limpanont Y, Lv ZY*. Detection of helminths by loop-mediated isothermal amplification assay: A review of updated technology and future outlook. Infect Dis Poverty. 2019,8(1):20. 7. Zhu GL, Tang YY, Limpanont Y, Wu ZD, Li J*, Lv ZY*. Zoonotic parasites carried by invasive alien species in China. Infect Dis Poverty. 2019 8(1):2. 8. Liu XL, Zhu GL, Cai CN, Lv ZY*, Li J*. Clonorchiasis sinensis detected by laparoscopic exploration of biliary tracts in two patients with obstructive jaundice. BMC Infec Dis. 2019,19(1):33. 9. Wu YQ, Liu JQ, Lin YF, Weng RN, Chen R, Li J, Lv ZY*. Diagnosis, Monitoring, and Control of Schistosomiasis - An Update. J Biomed Nanotechnol. 2018,14(3):430-455. 10. Lu XT, Gu QY, Limpanont Y, Song LG, Wu ZD, Okanurak K, Lv ZY*. Snail-borne parasitic diseases: an update on global epidemiological distribution, transmission interruption and control methods. Infect Dis Poverty. 2018,7(1):28 11. Mengying Z, Yiyue X, Tong P, Yue H, Limpanont Y, Ping H, Okanurak K, Yanqi W, Dekumyoy P, Hongli Z, Watthanakulpanich D, Zhongdao W, Zhi W, Zhiyue L*. Apoptosis and necroptosis of mouse hippocampal and parenchymal astrocytes, microglia and neurons caused by Angiostrongylus cantonensis infection. Parasit Vectors. 2017,10(1):611. 12. Liu J, Xu YY, He XJ, Zheng MH, Zhang MY, Hu Y, Wu YQ, Song LG, Zeng X, Lin DT, Wang S, Zheng HQ, Wu ZD, Lv ZY*. Study on the tolerance and adaptation of rats to Angiostrongylus cantonensis infection. Parasitol Res. 2017, 116(7):1937-1945. 13. Zheng SH, Zhu Y, Zhao ZJ, Wu ZD, Okanurak K, Lv ZY*. Liver fluke infection and cholangiocarcinoma: a review. Parasitol Res. 2017,116(1):11-19. 14. Wang M, Wu LX, Weng RN; Zheng WH, Wu ZD, Lv ZY*. Therapeutic potential of helminths in autoimmune diseases: helminth-derived immune-regulators and immune balance. Parasitol Res. 2017, 116(8):2065-2074. 15. Lin WH, Chen R, He XJ, Wu ZD, Paron D, Lv ZY*. Parasites and asthma. Parasitol Res. 2017,116(8):2373-2383. 16. He P, Song LG, Xie H, Liang JY, Yuan DY, Wu ZD, Lv ZY*. Nucleic acid detection in the diagnosis and prevention of schistosomiasis. Infect Dis Poverty. 2016,5:25. 17. Song LG, Wang ZW, Yang Z, Lv ZY*, Wu ZD*. Angiostrongylus cantonensis in the vector snails Pomacea canaliculata and Achatina fulica in China: a meta-analysis. Parasitol Res. 2016,115(3):913-923. 18. Liu J, Pan T, You X, Xu Y, Liang J, Limpanont Y, Sun X, Okanurak K, Zheng H, Wu Z, Lv Z*. SjCa8, a calcium-binding protein from Schistosoma japonicum, inhibits cell migration and suppresses nitric oxide release of RAW264.7 macrophages. Parasit Vectors. 2015,8:513. 19. Feng F, Feng Y*, Liu Z, Li WH, Wang WC, Wu ZD, Lv ZY*. Effects of albendazole combined with TSII-A (a Chinese herb compound) on optic neuritis caused by Angiostrongylus cantonensis in BALB/c mice, Parasites & Vectors. 2015,11(25):8 20. Wei J, Wu F, He A, Zeng X, Ouyang LS, Liu MS, Zheng HQ, Lei WL, Wu ZD*, Lv ZY*. Microglia activation: one of the checkpoints in the CNS inflammation caused by Angiostrongylus cantonensis infection in rodent model. Parasitol Res. 2015,114(9):3247-3254. 21. Lv ZY*, Wu ZD*, Zhang LM, Ji PY, Cai YF, Luo SQ, Wang HX, Li H. Genome mining offers a new starting point for parasitology research. Parasitol Res. 2015,114(2):399-409. 22. Ji PY, Hu HL, Yang XY, Wei XX, Zhu CC, Liu JC, Feng Y, Yang F, Okanurak K, Li N, Zeng X, Zheng HQ, Wu ZD, Lv ZY*. AcCystatin, an immunoregulatory molecule from Angiostrongylus cantonensis, ameliorates the asthmatic response in an aluminium hydroxide/ovalbumin-induced rat model of asthma. Parasitol Res. 2015,114(2):613-624. 23. Yang F, Long EP, Wen JH, Cao L, Zhu CC, Hu HX, Ruan Y, Okanurak K, Hu HL, Wei XX, Yang XY, Wang CF, Zhang LM, Wang XY, Ji PY, Zheng HQ, Wu ZD*, Lv ZY*. Linalool, derived from Cinnamomum camphora (L.) Presl leaf extracts, possesses molluscicidal activity against Oncomelania hupensis and inhibits infection of Schistosoma japonicum. Parasit Vectors. 2014, 7:407. 24. Li ST, Yang F, Ji PY, Zeng X, Wu XY, Wei J, Ouyang LS, Liang JY, Zheng HQ, Wu ZD, Lv ZY*. Eosinophil chemotactic chemokine profilings of the brain from permissive and non-permissive hosts infected with Angiostrongylus cantonensis. Parasitol Res. 2014, 113(2):517-525. 25. Zeng X, Wang J, Wei J, Wu F, Feng F, Wu XY, Sun X, Zheng HQ, Lv ZY*, Wu ZD*. Angiostrongylus cantonensis: tegumental and hypodermic alterations of the fourth-stage larvae following administration of tribendimidine in vivo and in vitro. Parasitol Res. 2013, 112(8):3035-3040. 26. Zeng X, Wei J, Wang J, Wu F, Fung F, Wu X, Sun X, Zheng H, Lv ZY*, Wu Z*. Angiostrongylus cantonensis: scanning electron microscopic observations on the cuticle of moulting larvae. Korean J Parasitol. 2013, 51(6):633-636. 27. Zhao J, Lv ZY #,Wang FZ, Wei J, Zhang QX, Li ST, Yang F, Zeng X, Wu XY, Wu ZD. Ym1, an eosinophilic chemotactic factor, participates in the brain inflammation induced by Angiostrongylus cantonensis. Parasitol Res. 2013, 112(7):2689-2695. 28. Han YP, Li ZY, Li BC, Sun X, Zhu CC, Ling XT, Zheng HQ, Wu ZD*, Lv ZY*. Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis. Parasitol Res. 2011, 109(2):369-378. 29. Liu YH, Han YP, Li ZY, Wei J, He HJ, Xu CZ, Zheng HQ, Zhan XM, Wu ZD*, Lv ZY*.Molecular cloning and characterization of cystatin, a cysteine protease inhibitor, from Angiostrongylus cantonensis. Parasitol Res. 2010, 107(4):915-922. 30. Zhou YP, Wu ZD, Yang LL, Sun X, You X, Yu XB, Hu W, Zheng HQ, Lv ZY*. Cloning, molecular characterization of a 13-kilodalton antigen from Schistosoma japonicum, Sj13, a putative salivary diagnosis candidate for schistosomiasis japonica. Parasitol Res. 2009, 105(5):1435-1444. 31. Lv ZY, Yang LL, Hu SM, Sun X, He SJ, Li ZY, Han YP, Wu ZD*. Expression profile, localization of an 8-kDa calcium-binding protein from Schistosoma japonicum (SjCa8), and vaccine potential of recombinant SjCa8 (rSjCa8) against infections in mice. Parasitol Res. 2009, 104(4):733-743. 32. Yang LL, Lv ZY#, Hu SM, He SJ, Li ZY, Zhang SM, Wu ZD. Schistosoma japonicum: Proteomics analysis of differentially expressed proteins from ultraviolet-attenuated cercariae compared to normal cercariae. Parasitol Res. 2009, 105(1):237-248.