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Chen M, Zheng F，Yuan G, Duan X, Rong L, Liu J, Feng S, Wang Z, Wang M, Feng Y, Zhou Q, Li J, Deng K, Li C, Xia J, Rao G, Zhou Y, Fu Y, Li YP*. Development of an infectious cell culture system for hepatitis C virus genotype 6a clinical isolate using a novel strategy and its sensitivity to direct-acting antivirals. Frontiers in Microbiology 2018; Accepted (in press). Wang Y, Chen X, Xie J, Zhou S, Huang Y, Li YP, Li X, Liu C, He J*, Zhang P*. RNA helicase A is an important host factor involved in dengue virus replication. Journal of Virology 2018; Accepted (in press). Zheng Y#, Liu Q#, Wu Y#, Ma L, Zhang Z, Liu T, Jin S, She Y, Li YP*, Cui J*. Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis. The EMBO Journal 2018;37(18). pii: e99347. PMID: 30065070 (PubMed) Chen Y, Liu T, Zhang Z, Chen M, Rong L, Ma L, Yu B, Wu, Zhang P, Zhu X, Huang X, Zhang H, Li YP*. Novel genetically stable infectious clone for a Zika virus clinical isolate and identification of RNA elements essential for virus production. Virus Research. 2018;257:14-24. PMID: 30144463 (PubMed) Duan X, Anwar MI, Xu Z, Ma L, Yuan G, Chen Y, Liu X, Xia J, Zhou Y, Li YP*. Adaptive Mutation F772S-enhanced p7-NS4A Cooperation Facilitated the Assembly and Release of Hepatitis C Virus and Associated with Enlargement of Lipid Droplets. Emerging Microbes & Infections 2018 Aug 8;7(1):143. PMID: 30087320 (PubMed) Humes D, Ramirez S, Jensen TB, Li YP, Gottwein JM, Bukh J*. Recombinant hepatitis C virus genotype 5a infectious cell culture systems expressing minimal JFH1 NS5B sequences permit polymerase inhibitor studies. Virology 2018;522:177-192. PMID: 30032031 (PubMed) Li J, Feng S, Liu X, Guo M, Chen M, Chen Y, Rong L, Xia J, Zhou Y, Zhong J, Li YP*. Identification of nucleotides in the 5'UTR and amino acids substitutions that are essential for the infectivity of 5'UTR-NS5A recombinant of hepatitis C virus genotype 1b (strain Con1). Virology 2018;518:253-263. PMID: 29549787 (PubMed) Yang JY, Deng XY, Li YS, Ma XC, Feng JX, Yu B, Chen Y, Luo YL, Wang X, Chen ML, Fang ZX, Zheng FX, Li YP, Zhong Q, Kang TB, Song LB, Xu RH, Zeng MS, Chen W, Zhang H, Xie W, Gao S*. Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control. Nature Communications 2018;9(1):1165. PMID: 29563550 (PubMed) Pham LV, Ramirez S, Gottwein JM, Fahnøe U, Li YP, Pedersen J, Bukh J*. HCV Genotype 6a Escape from and Resistance to Velpatasvir, Pibrentasvir, and Sofosbuvir in Robust Infectious Cell Culture Models. Gastroenterology 2018154(8):2194-2208.e12. PMID: 29454794 (PubMed) Hu L, Li J, Cai H, Yao W, Xiao J, Li YP, Qiu X, Xia H, Peng T*. Avasimibe: A novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles. Antiviral Research 2017;148:5-14. PMID: 29074218 (PubMed) Huang LH, Xu MY, Li HJ, Li JQ, Chen YX, Ma WZ, Li YP, Xu J*, Yang DP*, Lan WJ*. Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41−1 to Maximize Alkaloid Diversity. Organic Letters 2017;19:4888-4891. PMID:28837349 (PubMed) Yuan G, Liu J, Hu C, Huang H, Qi M, Wu T, Liang W, Li YP, Zhang YY, Zhou Y*. Genotype Distribution and Molecular Epidemiology of Hepatitis C Virus in Guangzhou, China: Predominance of Genotype 1b and Increasing Incidence of Genotype 6a. Cellular Physiology and Biochemistry 2017;43(2):775-787. PMID:28950254 (PubMed) Yin P, Zhang L, Ye F, Deng Y, Lu S, Li YP, Zhang L, Tan W*. A screen for inhibitory peptides of hepatitis C virus identifies a novel entry inhibitor targeting E1 and E2. Scientific Reports 2017;7(1):3976. PMID: 28638089 (PubMed) Fang S, Su J, Liang B, Li X, Li Y, Jiang J, Huang J, Zhou B, Ning C, Li J, Ho W, Li YP, Chen H, Liang H, Ye L*. Suppression of autophagy by mycophenolic acid contributes to inhibition of HCV replication in human hepatoma cells. Scientific Reports 2017;7:44039. PMID:28276509 (PubMed) Li X, Li Y, Fang S, Su J, Jiang J, Liang B, Huang J, Zhou B, Zang N, Ho W, Li J, Li YP, Chen H, Ye L, Liang H*. Downregulation of autophagy-related gene ATG5 and GABARAP expression by IFN-λ1 contributes to its anti-HCV activity in human hepatoma cells. Antiviral Research 2017;140:83-94. PMID:28131804 (PubMed) Pham LV, Ramirez S, Carlsen TH, Li YP, Gottwein JM, Bukh J*. Efficient hepatitis C virus genotype 1b Core-NS5A recombinants permit efficacy testing of protease and NS5A inhibitors. Antimicrobial Agents and Chemotherapy 2017 24;61(6). pii: e00037-17, PMID:28348150 (PubMed) Chi X, Niu Y, Cheng M, Liu X, Feng Y, Zheng F, Fan J, Li X, Jin Q, Zhong J, Li YP, Yang W*. Identification of a Potent and Broad-Spectrum Hepatitis C Virus Fusion Inhibitory Peptide from the E2 Stem Domain. Scientific Reports 2016;6:25224. PMID:27121372 (PubMed) Serre SB, Jensen SB, Ghanem L, Humes DG, Ramirez S, Li YP, Krarup H, Bukh J, Gottwein JM*. Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle. Antimicrobial Agents and Chemotherapy 2016;60(6):3563-78. PMID:27021330 (PubMed) Li YP#, Van Pham L#, Uzcategui N, Bukh J. Functional analysis of microRNA-122 binding sequences of hepatitis C virus and identification of variants with high resistance against a specific antagomir. Journal of General Virology 2016;97(6):1381-94. PMID:26935756 (PubMed) Jensen SB, Serre SB, Humes DG, Ramirez S, Li YP, Bukh J, Gottwein JM*. Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance. Antimicrobial Agents and Chemotherapy 2015;59(12):7426-36. PMID:26392503 (PubMed)
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