林贤 - 中山大学 - 中山医学院

个人简介

分别于1995年和2000年在福建医科大学获学士学位和硕士学位，2003年于中山大学中山医学院(原中山医科大学)获医学博士学位。1995年至2000年在福建医科大学解剖学教研室任助教，2003年至2004年在中山大学解剖学系任讲师；2004年至2009年在美国NIH做博士后研究工作；2009-2010在NIH做Research Fellow；2010年10月作为中山大学“百人计划”引进人才回国工作。

研究领域

研究方向一：帕金森氏病（PD）相关基因和蛋白的功能性研究。帕金森氏病具有显性家族遗传性的相关基因为alpha-synuclein和LRRK2，我们首次证明了LRRK2 能够在体内特异性加剧alpha-synuclein诱发的病理性变化，并阐明了其作用的分子病理机制。目前研究的内容：1. 探索LRRK2 和alpha-synuclein之间相互作用的信号传导途径。2. 以PD核心病理性蛋白alpha-synuclein为靶目标，研究其他PD病理性蛋白（如tau蛋白）与其之间的分子相互作用机制。研究方向二：PD的表观遗传学研究，我们的目的着眼于研究中脑不同部位的多巴胺神经元的表观遗传修饰的差异及其原因，来解释PD的发生机制。研究方向三：免疫炎症在PD发生发展中的作用。

近期论文

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(1) Zheng M, Jiao L, Tang X, Xiang X, Wan X, Yan Y, Li X, Zhang G, Li Y, Jiang B, Cai H, Lin Xian*. Tau haploinsufficiency causes prenatal loss of dopaminergic neurons in the ventral tegmental area and reduction of transcription factor orthodenticle homeobox 2 expression. FASEB J, Published online Apr 19, 2017. (2) Mo M, Xiao Y, Huang S, Cen L, Chen X, Zhang L, Luo Q, Li S*, Yang X*, Lin X*, Xu P*. Oncotarget, 2017, 8(1):15-28. (3)Li X, Zhang G, Nie Q, Wu T, Jiao L, Zheng M, Wan X, Li Y, Wu S, Jiang B, Xiang X, Duan J, Lin X*. Baicalein blocks α-synuclein secretion from SN4741 cells and facilitates α-synuclein polymerization to big complex. Neuroscience Letter, 2017, Jul 1;655:109-114. (3) Xian Lin, Loukia Parisiadou, Carmelo Sgobio, Guoxiang Liu, Jia Yu, Lixin Sun, Hoon Shim, Xing-Long Gu, Jing Luo, Cai-Xia Long, Jinhui Ding, Yolanda Mateo, Patricia H. Sullivan, Ling-Gang Wu, David S. Goldstein, David Lovinger, and Huaibin Cai.Conditional Expression of Parkinson's Disease-Related Mutant α-Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1.The Journal of Neuroscience, 2012, 32(27):9248-64. (4) Xian Lin, Loukia Parisiadou, Xing-Long Gu, et al. Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathologyalpha-synuclein. Neuron, 2009,64:807-827.(First featured papers with first preview). (5) Chen Lai#, Xian Lin#, Jayanth Chandran, et al. The G59S mutation in p150 causes dysfunction in mice. The Journal of Neuroscience, 2007, 27(51):13982-13900.(co-first author, cover introduction). (6) Xian Lin, Hoon Shim, Huaibin Cai. Deficiency in the ALS2 gene does not affect the motor neuron degeneration in SOD1(G93A) transgenic mice. Neurobiol Aging, 2007, 28(10):1628-30. (7) Cai H, Lin X, Xie C, et al. Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. The Journal of Neuroscience, 2005, 25(33):7567-74. (8) Chandran JS, Lin X, Zapata A, et al. Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis, 2008, 29(3):505-14. (9) Cai H, Shim H, Lai C, Xie C, Lin X, Yang WJ, Chandran J.ALS2/alsin knockout mice and motor neuron diseases. Neurodegener Dis, 2008; 5(6):359-66. (10) Loukia Parisiadou, Chengsong Xie, Hyun Jin Cho, Xian Lin, Xing-Long Gu, Cai-Xia Long, Evy Lobbestael, Veerle Baekelandt, Jean-Marc Taymans, Lixin Sun, and Huaibin Cai Phosphorylation of Ezrin-Radixin-Moesin Proteins by LRRK2 Promotes the Rearrangement of Actin Cytoskeleton in Neuronal Morphogenesis. The Journal of Neuroscience, 2008, 29(44):13971-80. (11) Luo J#, Sun L, Lin X, Liu G, Yu J, Parisiadou L, Xie C, Ding J, Cai H*. A calcineurin- and NFAT-dependent pathway is involved in α-synuclein-induced degeneration of midbrain dopaminergic neurons. Hum Mol Genet, 2014, 23(24):6567-74. (12)Parisiadou L#*, Yu J#, Sgobio C#, Xie C, Liu G, Sun L, Gu XL, Lin X, Crowley NA, Lovinger DM, Cai H*. LRRK2 regulates synaptogenesis and dopamine receptor activation through modulation of PKA activity. Nat Neurosci, 2014, 17(3):367-76.