吴敏昊 - 中山大学 - 中山医学院

个人简介

2002.9-2006.7 中国科学技术大学生命科学学院生物科学专业本科 2006.8-2010.5 美国韦恩州立大学医学院解剖与细胞生物学专业博士研究生 2014.2-2015.2 美国康奈尔医学院附属Methodist研究所免疫生物学系博士后 2010.6-2015.12 中山大学中山医学院免疫学研究所副教授 2016.1至今中山大学中山医学院免疫学研究所教授

研究领域

1）感染、免疫和炎症的调控机制研究，特别是模式识别受体及TNFR受体超家族对巨噬细胞和T细胞的功能调控及其在相关疾病中的作用机制 2）基于免疫学和纳米生物学的肿瘤诊断技术和防治策略研究

近期论文

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Zhu S#, Chen Y#, Lao J#, Wu C, Zhan X, Wu Y, Shang Y, Zou Z, Zhou J, Ji X, Huang X, Shi X*, Wu M*. Signaling Lymphocytic Activation Molecule Family-7 Alleviates Corneal Inflammation by Promoting M2 Polarization. J Infect Dis. 2021;223(5):854-865. Fan H#, Lu B#, Cao C#, Li H, Yang D, Huang L, Ding T, Wu M*, Lu G*. Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients. Front Immunol. 2021;11:614781. Liu T#, Tan J#, Wu M#, Fan W, Wei J, Zhu B, Guo J, Wang S, Zhou P, Zhang H, Shi L, Li J*. High-affinity neoantigens correlate with better prognosis and trigger potent antihepatocellular carcinoma (HCC) activity by activating CD39+CD8+ T cells. Gut. 2020:gutjnl-2020-322196. Chen L#, Liang S#, Chen Y, Wu M*, Zhang Y*. Destructing the plasma membrane with activatable vesicular DNA nanopores., ACS Applied Materials & Interfaces, 2019, 12(1): 96-105. Zhang M#, Ming S#, Gong S, Liang S, Luo Y, Liang Z, Cao C, Lao J, Shang Y, Li X, Wang M, Zhong G, Xu L, Wu M*, Wu Y*. Activation-Induced Cell Death of Mucosal-Associated Invariant T Cells Is Amplified by OX40 in Type 2 Diabetic Patients. Journal of Immunology. 2019,203 (10), 2614-2620. Qu W, Wang Y, Wu Y, Liu Y, Chen K, Liu X, Zou Z, Huang X, Wu M*. Triggering Receptors Expressed on Myeloid Cells 2 Promotes Corneal Resistance Against Pseudomonas aeruginosa by Inhibiting Caspase-1-Dependent Pyroptosis. Frontiers in Immunology. 2018;9:1121. Chen K＃, Fu Q＃, Liang S＃, Liu Y, Qu W, Wu Y, Wu X, Wei L, Wang Y, Xiong Y, Wang W*, Wu M*. Stimulator of Interferon Genes Promotes Host Resistance Against Pseudomonas aeruginosa Keratitis. Frontiers in Immunology. 2018;9:1225. Wu Y＃, Li D＃, Wang Y, Liu X, Zhang Y, Qu W, Chen K, Francisco NM, Feng L, Huang X, Wu M*. Beta-Defensin 2 and 3 Promote Bacterial Clearance of Pseudomonas aeruginosa by Inhibiting Macrophage Autophagy through Downregulation of Early Growth Response Gene-1 and c-FOS. Frontiers in Immunology. 2018;9:211. Zhao Z, Chen Y, Francisco NM, Zhang Y*, Wu M*. The application of CAR-T cell therapy in hematological malignancies: Advantages and challenges. Acta Pharmaceutica Sinica B. 2018;8 (4):539-551 Wu Y #, Li D #, Wang Y #, Chen K, Yang K, Huang X, Zhang Y *, Wu M *. Pseudomonas aeruginosa promotes autophagy to suppress macrophage-mediated bacterial eradication. International Immunopharmacology. 2016;38：214-222. Deng Q #, Wang Y #, Zhang Y, Li M, Li D, Huang X, Wu Y, Pu J, Wu M*. Pseudomonas aeruginosa Triggers Macrophage Autophagy To Escape Intracellular Killing by Activation of NLRP3 Inflammasome. Infection and Immunity. 2015;84(1):56-66. Zhan X, Fang Y, Hu S, Wu Y, Yang K, Liao C, Zhang Y, Huang X, Wu M*. IFN-g differentially regulates subsets of Gr-1+CD11b+ myeloid cells in chronic inflammation. Molecular Immunology.2015;66(2):451-462. Zhang Y#, Wu M#, Han X, Wang P*; Qin L*; High-throughput, Label-free isolation of cancer stem cells on the basis of cell adhesion capacity. Angewandte Chemie International Edition, 2015, 54(37):10838-10842. Zhu M #, Li D #, Wu Y, Huang X, Wu M*. TREM-2 Promotes Macrophage- Mediated Eradication of Pseudomonas aeruginosa via a PI3K/Akt Pathway. Scandinavian Journal of Immunology. 2014;79(3):187-196. Yang K #, Wu M #, Li M, Li D, Peng A, Nie X, Sun M, Wang J, Wu Y, Deng Q, Zhu M, Chen K,Yuan J, Huang X*. miR-155 suppresses bacterial clearance in Pseudomonas aeruginosa-induced keratitis by targeting Rheb. Journal of Infectious Diseases. 2014;210(1):89-98. Kang Chen, Lin Yin, Xinxin Nie, Qiuchan Deng, Yongjian Wu, Min Zhu, Dandan Li, Meiyu Li, Minhao Wu*, Xi Huang*. β-Catenin promotes host resistance against Pseudomonas aeruginosa keratitis. Journal of Infection, 2013, 67(6):584-594. Kun Yang #, Jinli Wang#, Peng Andy Xiang, Xiaoxia Zhan, Yi Wang, Minhao Wu *, X Huang*. Functional RIG-I-like receptors control the survival of mesenchymal stem cells. Cell Death&Disease, 2013, 4:e967. Mingxia Sun#, Min Zhu#, Kang Chen, Xinxin Nie, Qiuchan Deng, Linda D. Hazlett, Yongjian Wu, Meiyu Li, Minhao Wu*, Xi Huang*. TREM-2 Promotes Host Resistance Against Pseudomonas aeruginosa Infection by Suppressing Corneal Inflammation via a PI3K/Akt Signaling Pathway. Investigative Ophthalmology & Visual Science, 2013, 54(5):3451-3462. Qiuchan Deng#, Mingxia Sun#, Kun Yang, Min Zhu, Kang Chen, Jin Yuan, Minhao Wu*, Xi Huang*. MRP8/14 enhances corneal susceptibility to Pseudomonas aeruginosa Infection by amplifying inflammatory responses. Investigative Ophthalmology & Visual Science, 2013, 54(2):1227-1234. Kang Chen#, Yongjian Wu#, Min Zhu, Qiuchan Deng, Xinxin Nie, Meiyu Li, Wu M*, Xi Huang*. Lithium chloride promotes host resistance against Pseudomonas aeruginosa keratitis. Molecular Vision, 2013, 19:1502-1514. Minhao Wu#, Anping Peng#, Mingxia Sun, Qiuchan Deng, Linda D. Hazlett, Jin Yuan, Xialin Liu, Qianying Gao, Lianqiang Feng, Junfang He, Ping Zhang*, Xi Huang*. TREM-1 Amplifies Corneal Inflammation after Pseudomonas aeruginosa Infection by Modulating Toll-Like Receptor Signaling and Th1/Th2-Type Immune Responses. Infection and Immunity. 2011. 79(7):2709-2716