黄潋滟 - 中山大学 - 中山医学院

个人简介

黄潋滟博士本科毕业于原第一军医大学临床医学专业，后师从我国公共卫生学著名学者邹飞教授获得细胞生物学硕士及博士学位。2012年至2017年在美国纽约大学Guang Yang及Wenbiao Gan教授实验室完成博士后培训，该实验室为在体双光子成像领域国际领军实验室。

研究领域

黄潋滟教授课题组利用在体双光子显微结构成像技术、在体钙成像技术及分子生物学技术等多种研究手段，探讨学习记忆的神经环路及分子机制，并探索精神疾病及神经胶质瘤的发病机制。主要研究方向包括：1）全身麻醉引起认知障碍的机制及防治措施；2）情感记忆的神经环路；3）慢性疼痛形成的神经环路及治疗手段；4）神经免疫在神经/精神疾病中的作用；5)神经胶质瘤的发病机制及治疗靶点。

近期论文

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1. Lianyan Huang, Joseph Cichon, Ipe Ninan, Guang Yang. Post-anesthesia potentiation of AMPA receptor activity prevents anesthesia-induced learning and synaptic deficits. Science Translational Medicine 2016 22;8(344):344ra85. (Cover Story, Comment in Nature News & Views) 2. Lianyan Huang, Guang Yang. Repeated Exposure to Ketamine–Xylazine during Early Development Impairs Motor Learning–dependent Dendritic Spine Plasticity in Adulthood. Anesthesiology 2015 122(4):821-31 3. Lianyan Huang#, Boxing Li#, Shihao Tang, Hongbo Guo, Wenjun Li, Xiaozhou Huang, Wenjuan Yan, Fei Zou. Mitochondrial KATP Channels Control Glioma Radioresistance by Regulating ROS-Induced ERK Activation. Molecular Neurobiology 2015 52(1):626-37. 4. Lianyan Huang#, Boxing Li#, Wenjun Li, Hongbo Guo, Fei Zou. ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity. Carcinogenesis 2009, 30(5):737–744. 5. Lianyan Huang#, Wenjun Li#, Boxing Li, Fei Zou*. Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. Neuroscience Letters 2006, 398:34–38. 6. Boxing Li, Wei Jie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K. Friedman, Andrea L. Meredith, Ming-Hu Han, Xin-Hong Zhu, Tian-Ming Gao. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nature Neuroscience 2014, 17: 1055–1063 7. Bin Wang, Yu Liu, Lianyan Huang, Jianjun Chen, Jing jing Li, Ruishan Wang, Eunhee Kim, Carles Justicia, Kazuko Sakata, Hao Chen, Anna Planas, Rennolds Ostrom, Wei Li, Guang Yang, Michael McDonald, Ruihong Chen, Detlef Heck, Francesca-Fang Liao. A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism. Molecular Psychiatry 2016 Jul 26. doi: 10.1038/mp.2016.104. [Epub ahead of print] 8. Hongzhan Liao, Yifeng Bai, Shengcong Qiu, Lei Zheng, Lianyan Huang, Tianzhu Liu, Xin Wang, Yanting Liu, Ningbo Xu, Xiaohui Yan and Hongbo Guo. MiR-203 downregulation is responsible for chemoresistance in human glioblastoma by promoting epithelial-mesenchymal transition via SNAI2. Oncotarget. 2015, 20;6(11):8914-28. 9. Hongbo Guo, Lianyan Huang, Yuxi Zou, Fei Zou. Up-regulation of the transient A-type K+ current (IA) in the differentiation of neural stem cells of the early postnatal rat hippocampus. Chin Med J (Engl). 2010 Jul;123(13):1731-5.