王继厂 - 中山大学 - 中山医学院

个人简介

2006年于南京医科大学获得医学学士学位，2009年于南京医科大学获得医学硕士学位，2015年于德国柏林自由大学获得博士学位。攻读博士学位期间，以Scientist身份在德国马克斯-德尔布吕克分子医学中心进行博士课题研究。博士毕业后，在德国亥姆霍兹联合会的资助下，以Helmholtz Postdoctoral Fellow身份（独立的项目PI），继续在马克斯-德尔布吕克分子医学中心进行科学研究。

研究领域

王继厂博士主要从事人源多能干细胞的基础和临床转化研究，同时涉及先天性单基因遗传病的基因治疗研究。

近期论文

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1. Yongming Wang*, Diana Pryputniewicz-Dobrinska*, Enikö Nagy*, Christopher Kaufman, Manvendra Singh, Stephen Yant, Jichang Wang, Anna dalda, M Kay, Zoltán Ivics, Zsuzsanna Izsvák#. Regulated Complex Assembly Safeguards the Fidelity of Sleeping Beauty Transposition. Nucleic Acids Res. 2017;45(1):311-326. 2. Liang Hu*, Jichang Wang*, Hongyi Zhu, Xiaowei Wu, Lu Zhou, Yichen Song, Suhua Zhu, Maojuan Hao, Chao Liu, Yue Fan, Yu Wang, Qingping Li#. Ischemic postconditioning protects the heart against ischemia-reperfusion injury via neuronal nitric oxide synthase in the sarcoplasmic reticulum and mitochondria. Cell Death Dis. 2016; 7: e2222. 3. Jichang Wang, Manvendra Singh, Chuanbo Sun, Daniel Besser, Alessandro Prigione, Zoltán Ivics, Laurence D. Hurst#, Zsuzsanna Izsvák#. Isolation and Cultivation of Naïve-like Human Pluripotent Stem Cells based on HERVH Expression. Nat Protoc. 2016; 11(2): 327-346.(Featured in Nature Protocols; Cover article) 4. Sabine Klawitter*, Nina V. Fuchs*, Kyle R. Upton*, Martin Muñoz-Lopez*, Ruchi Shukla, Jichang Wang, Marta Garcia-Canadas, Cesar Lopez-Ruiz, Daniel J. Gerhardt, Attila Sebe, Ivana Grabundzija, Sylvia Merkert, Anja Bock, Ulrike Held, Anett Witthuhn, Alexandra Haase, Balázs Sarkadi, Johannes Löwer, Ernst J. Wolvetang, Ulrich Martin, Zoltán Ivics, Zsuzsanna Izsvák, Jose L. Garcia-Perez#, Geoffrey J. Faulkner#, Gerald G. Schumann#. Reprogramming triggers endogenous L1, Alu and SVA retrotransposition in human induced pluripotent stem cells. Nat Commun. 2016; 7: 10286.  5. Zsuzsanna Izsvák#, Jichang Wang, Manvendra Singh, Dixie L. Mager, Laurence D. Hurst. Pluripotency and the endogenous retrovirus HERVH: Conflict or serendipity? BioEssays. 2016; 38(1): 109-117. (Invited review) 6. Jichang Wang*, Gangcai Xie*, Manvedra Singh, Avazeh T. Ghanbarian, Tamás Raskó, Attila Szvetnik, Huiqiang Cai, Daniel Besser, Alessandro Prigione, Nina Fuchs, Gerald Schumann, Wei Chen, Matthew C. Lorincz, Zoltán Ivics, Laurence D. Hurst#, Zsuzsanna Izsvák#. Primate-specific endogenous retrovirus driven transcription defines naïve-like stem cells. Nature. 2014; 516(7531): 405-409. 7. Yongming Wang*, Jichang Wang*, Anatharam Devaraj, Manvendra Singh, Ana Jimenez Orgaz, Jia-Xuan Chen, Matthias Selbach, Zoltán Ivics#, Zsuzsanna Izsvák#. Suicidal autointegration of sleeping beauty and piggyback transposons in eukaryotic cells. PLoS Genet. 2014; 10(3): e1004103. 8. Wenli Zhang; Manish Solanki, Melanie Ebel, Chistina Rauschhuber, Nadine Müther, Jichang Wang, Chuanbo Sun, Zsuzsanna Izsvak, Anja Ehrhardt. Hybrid adeno-associated viral vectors utilizing transposase-mediated somatic integration for stable transgene expression in human cells. PLoS ONE. 2013; 8(10): e76771. 9. Wenli Zhang, Martin Muck-Hausl, Jichang Wang, Chuanbo Sun, Maren Gebbing, Csaba Miskey, Zoltan Ivics, Zsuzsanna Izsvak and Anja Ehrhardt. Integration profile and safety of an adenovirus hybrid-vector utilizing hyperactive Sleeping Beauty transposase for somatic integration. PLoS ONE. 2013; 8(10): e75344. 10. Ivana Grabundzija*, Jichang Wang*, Attila Sebe*, Zsuzsanna Erdei, Robert Kajdi, Anantharam Devaraj, Doris Steinemann, Károly Szuhai, Ulrike Stein, Tobias Cantz, Axel Schambach, Christopher Baum, Zsuzsanna Izsvák#, Balázs Sarkadi#, and Zoltán Ivics#. Sleeping Beauty transposon-based system for cellular reprogramming and targeted gene insertion in induced pluripotent stem cells. Nucleic Acids Res. 2013; 41(3): 1829-1847.   