周洁 - 中山大学 - 中山医学院

个人简介

教育及工作经历： 2004年获得中南大学湘雅医学院“病理学与病理生理学”博士学位 2004年9月至2009年10月在美国从事博士后工作 2010年1月通过中山大学“百人计划”引进

研究领域

髓系抑制性细胞（MDSC）的调控机制及其病理意义研究：MDSC是免疫系统的重要“刹车”，我们主要研究MDSC在免疫相关疾病（肿瘤﹑病毒感染﹑哮喘﹑自身免疫病等）及生理性免疫耐受中的作用及病理生理意义，以期为基于MDSC的免疫治疗提供新策略和新靶点。研究成果已发表于J Allergy Clin. Immunol. (2014)，J Virol. (2013)，J Clin Immunol. (2014)，Eur J Immunol. (2013)等免疫学主流期刊；2 树突状细胞（DC）分化调控的机制研究：DC是机体最重要的抗原呈递细胞，我们主要研究调控造血干细胞向DC定向分化的分子机制，以期为基于DC的免疫治疗提供干预靶点。相关成果以第一作者及通讯作者发表在Immunity (2009)，J Immunol. (2013)，Mol Cell Biol. (2014)，Mol Immunol. (2014)。

近期论文

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（1） Quan Yang#, Jianyang Wei, Limei Zhong, Maohua Shi, Pan Zhou, Shengkai Zuo, Kang Wu, Mingjiang Zhu, Xi Huang, Ying Yu, Hui Zhang, Huiyong Yin, Jie Zhou*. Cross Talk between Histone Deacetylase 4 and STAT6 in the Transcriptional Regulation of Arginase 1 during Mouse Dendritic Cell Differentiation. Mol Cell Biol. 2015;35(1):63-75. (IF: 5.036) （2） Qiong Yang#, Maohua Shi, Yujun Shen, Yingjiao Cao, Shengkai Zuo, Caojian Zuo, Hui Zhang, Dmitry I Gabrilovich, Ying Yu*, Jie Zhou*. COX-1-derived thromboxane A2 plays an essential role in early B-cell development via regulation of JAK/STAT5 signaling in mouse. Blood. 2014;124(10):1610-1621. (IF: 9.775) （3） Maohua Shi#, Guochao Shi#, Juan Tang, Deping Kong , Yao Bao , Bing Xiao, Caojian Zuo , Tai Wang, Qingsong Wang, Yujun Shen, Hui Wang, Colin D Funk, Jie Zhou*, Ying Yu*. Myeloid-derived suppressor cell function is diminished in aspirin-triggered allergic airway hyperresponsiveness in mice. J Allergy Clin Immunol. 2014;134(5):1163-1174. (IF: 11.248) （4） Limei Zhong#, Quan Yang, Wen Xie, Jie Zhou*. Liver X receptor regulates mouse GM-CSF-derived dendritic cell differentiation in vitro. Mol Immunol. 2014;60(1):32-43. (IF: 3.0) （5） Jingyin Dong#, Jianyang Wei, Limei Zhong, Qiong Yang, Jiuling Tuo, Pan Zhou, Jie Fang, Weiping Cai, Xiaoyi Sun*, Jie Zhou*. Ribavirin enhances myeloid-derived suppressor cell differentiation through CXCL9/10 downregulation. Immunopharmacol Immunotoxicol. 2014;36(6):412-419. (IF: 1.1) （6） Dehong Yan#, Quan Yang, Maohua Shi, Limei Zhong, Changyou Wu, Tao Meng, Huiyong Yin, Jie Zhou*. Polyunsaturated fatty acids promote the expansion of myeloid-derived suppressor cells by activating the JAK/STAT3 pathway. Eur J Immunol. 2013;43(11):2943-2955. (IF: 4.518) （7） Aiping Qin#, Weiping Cai#, Ting Pan#, Kang Wu, Qiong Yang, Nina Wang, Yufeng Liu, Dehong Yan, Fengyu Hu, Pengle Guo, Xiaoping Chen, Ling Chen, Hui Zhang, Xiaoping Tang*, Jie Zhou*. Expansion of Monocytic Myeloid-Derived Suppressor Cells Dampens T Cell Function in HIV-1-Seropositive Individuals. J Virol. 2013;87(3):1477-1490. (IF: 4.648) （8） Weiping Cai# Clinical Significance and Functional Studies of Myeloid-Derived Suppressor Cells in Chronic Hepatitis C Patients. J Clin Immunol. 2013;33(4):798-808. (IF: 2.654)., Aiping Qin#, Pengle Guo, Dehong Yan, Fengyu Hu, Qiong Yang, Min Xu, Yongshui Fu, Jie Zhou*, Tang Xiaoping*. （9） Hao Liu#, Jie Zhou#, Pingyan Cheng, Indu Ramachandran, Yulia Nefedova, Dmitry I Gabrilovich*. Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis. J Immunol. 2013;191(4):1916-1926. (IF: 5.362) （10） Pingyan Cheng#, Jie Zhou#, Dmitry I Gabrilovich*. Regulation of dendritic cell differentiation and function by Notch and Wnt pathways. Immunol. Rev. 2010;234(1):105-119. (IF: 12.909) （11） Jie Zhou#, Pingyan Cheng, Je-In Youn, Matthew J Cotter, Dmitry I Gabrilovich*. Notch and Wingless Signaling Cooperate in Regulation of Dendritic Cell Differentiation. Immunity. 2009;30(6):845-859. (IF: 19.748) （12）Jie Zhou#, Maria Febbraio, Taira Wada, Yonggong Zhai, Ramalinga Kuruba, Jinhan He, Jung Hoon Lee, Shaheen Khadem, Songrong Ren, Song Li, Roy L Silverstein, Wen Xie*. Hepatic fatty acid transporter Cd36 is a common target of LXR, PXR, and PPAR gamma in promoting steatosis. Gastroenterology. 2008;134(2):556-567. (IF: 13.926)