董俊超 - 中山大学 - 中山医学院

个人简介

董俊超博士现任中山大学中山医学院教授，博士生导师。2002年于复旦大学生命科学学院获得学士学位；2010年于美国德克萨斯大学圣安东尼奥健康科学中心获得博士学位；2011年起在美国哈佛大学医学院附属波士顿儿童医院从事博士后研究，导师为霍华德休斯医学研究所资深研究员和美国科学院院士、著名免疫学家Frederick Alt教授。

研究领域

主要研究领域和兴趣为DNA双链断裂的修复途径和基因组不稳定性的机制。目前研究工作主要集中在以遗传学方法结合高通量DNA测序研究小鼠B淋巴细胞抗体基因重排、DNA双链断裂修复的机制及相关修复途径缺失而导致的原发性免疫缺陷疾病。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Panchakshari RA, Zhang X, Kumar V, Du Z, Wei PC, Kao J, Dong J*, Alt FW*. DNA double-strand break response factors influence end-joining features of IgH class switch and general translocation junctions. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):762-767. (*co-senior author) 2. Nguyen HV, Dong J, Panchakshari RA, Kumar V, Alt FW, Bories JC. Histone methyltransferase MMSET promotes AID-mediated DNA breaks at the donor switch region during class switch recombination. Proc Natl Acad Sci U S A. 2017 Dec 5;114(49) 3. Hu J, Meyers RM, Dong J, Panchakshari RA, Alt FW, Frock RL. Detecting DNA double-stranded breaks in mammalian genomes by linear amplification-mediated high-throughput genome-wide translocation sequencing. Nat Protoc. 2016 May;11(5):853-71 4. Dong J#, Panchakshari RA#, Zhang T#, Zhang Y, Hu J, Volpi SA, Meyers RM, Ho YJ, Du Z, Robbiani DF, Meng F, Gostissa M, Nussenzweig MC, Manis JP, Alt FW. Orientation-specific joining of AID-initiated DNA breaks promotes antibody class switching. Nature. 2015 Sep 3;525(7567):134-9 (#co-first author) 5. Gostissa M, Schwer B, Chang A, Dong J, Meyers RM, Marecki GT, Choi VW, Chiarle R, Zarrin AA, Alt FW. gH class switching exploits a general property of two DNA breaks to be joined in cis over long chromosomal distances. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2644-9 6. Li F#, Dong J#, Eichmiller R, Holland C, Minca E, Prakash R, Sung P, Shim E, Surtees JA, Eun Lee S. Role of Saw1 in Rad1/Rad10 complex assembly at recombination intermediates in budding yeast. EMBO J. 2013 Feb 6;32(3):461-72 (#co-first author) 7. Toh GW#, Sugawara N#, Dong J#, Toth R, Lee SE, Haber JE, Rouse J.Mec1/Tel1-dependent phosphorylation of Slx4 stimulates Rad1/Rad10 dependent cleavage of non-homologous DNA tails. DNA Repair (Amst). 2010 Jun 4;9(6):718-2 (#co-first author) 8. Li F, Dong J#, Pan X, Oum JH, Boeke JD, Lee SE. Microarray- based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates.Mol Cell. 2008 May 9;30(3):325-35 (#co-first author)