张宏波 - 中山大学 - 中山医学院

个人简介

现任中山大学中山医学院教授、博士生导师，广东省青年珠江学者。张宏波教授2010 年毕业于上海交通大学获理学硕士学位，随后赴瑞士苏黎世大学和洛桑瑞士联邦理工大学师从代谢领域权威Johan Auwerx教授攻读博士学位。其研究工作第一次揭示了干细胞衰老的线粒体失衡机制，提出线粒体应激（Mitochondrial stress）在调节骨骼肌干细胞衰老中的重要作用，并发现了NAD+依赖的抑制骨骼肌营养不良疾病和干细胞衰老的小分子营养干预方法。相关成果发表于 Science、Science Translational Medicine、Nature Reviews Endocrinology、Kidney International 等期刊，并获第一发明人国际专利2项。

研究领域

1. 成体干细胞衰老机制研究 2. 能量代谢和线粒体对成体干细胞功能和命运决定的影响 3. 骨骼肌稳态对系统能量代谢的调节

近期论文

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1 Wang, S., Zhang, B., Addicks, G. C., Zhang, H., Keir, J. M.*, & Zhang, H*. Muscle Stem Cell Immunostaining. Current Protocols in Mouse Biology, 8(3), e47. (2018) (*, corresponding authors) 2 Zhang, H., Menzies, K. J., & Auwerx, J. The role of mitochondria in stem cell fate and aging. Development, 145(8). (2018) 3 Addicks, G. C., Marshall, P., Jasmin, B. J., Renaud, J. M., Zhang, H. *, & Menzies, K. J. * Critical Assessment of the mdx Mouse with Ex Vivo Eccentric Contraction of the Diaphragm Muscle. Current Protocols in Mouse Biology, 8(3), e49. (2018) (*, corresponding authors) 4 Li, H., Wang, X., Rukina, D., Huang, Q., Lin, T., Sorrentino, V., Zhang, H., Bou Sleiman, M., Arends, D., McDaid, A., Luan, P., Ziari, N., Velazquez-Villegas, L. A., Gariani, K., Kutalik, Z., Schoonjans, K., Radcliffe, R. A., Prins, P., Morgenthaler, S., Williams, R. W., & Auwerx, J. An Integrated Systems Genetics and Omics Toolkit to Probe Gene Function. Cell Systems, 6(1), 90-102 e104 (2018). 5 Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D'Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., Counts, S. E., & Auwerx, J. Enhancing mitochondrial proteostasis reduces amyloid-beta proteotoxicity. Nature, 552(7684), 187-193. (2017) 6 Gariani, K., Ryu, D., Menzies, K. J., Yi, H. S., Stein, S., Zhang, H., Perino, A., Lemos, V., Katsyuba, E., Jha, P., Vijgen, S., Rubbia-Brandt, L., Kim, Y. K., Kim, J. T., Kim, K. S., Shong, M., Schoonjans, K., Auwerx, J. Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. Journal of Hepatology, 66, 131-142, (2017). 7 Zhang, H., Ryu, D., Wu, Y., Gariani, K., Wang, X., Luan, P., D'Amico, D., Ropelle, E. R., Lutolf, M. P., Aebersold, R., Schoonjans, K., Menzies, K. J. & Auwerx, J. NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice. Science, 352, 1436-1443, (2016). Be selected for perspective in Science, 352, 1396 (2016); highlighted in Nature Reviews Molecular Cell Biology, 17, 331 (2016), Cell Research, 16, 971 (2016) and recommended in F1000 prime. 8 Ryu, D.#, Zhang, H.#, Ropelle, E. R.#, Mazala, D. G., Mouchiroud, L., Sorrentino, V., Campbell, M. D., Ali, A. S., Bellemin, S., Lyer, S., Gariani, K., Sauve, A. A., Canto, C., Conley, K. E., Walter, L., Lovering, R. M., Chin, E. R., Marcinek, D. J. Menzies, K. J., & Auwerx, J. NAD+ repletion improves muscular dystrophy by countering increased levels of PARylation. Science Translational Medicine, 361, 361ra139 (2016). (#, equal contribution). 9 Menzies, K. J.#, Zhang, H.#, Katsyuba, E.# & Auwerx, J. Protein acetylation in metabolism - metabolites and cofactors. Nature Reviews Endocrinology, 12, 43-60, (2016). (#, equal contribution) 10 Rabhi, N., Denechaud, P. D., Gromada, X., Hannou, S. A., Zhang, H., Rashid, T., Salas, E., Durand, E., Sand, O., Bonnefond, A., Yengo, L., Chavey, C., Bonner, C., Kerr-Conte, J., Abderrahmani, A., Auwerx, J., Fajas, L., Froguel, P. & Annicotte, J. S. KAT2B Is Required for Pancreatic Beta Cell Adaptation to Metabolic Stress by Controlling the Unfolded Protein Response. Cell Reports, 165, 1051-1061, (2016). 11 Gariani, K., Menzies, K. J., Ryu, D., Wegner, C. J., Wang, X., Ropelle, E. R., Moullan, N., Zhang, H., Perino, A., Lemos, V., Kim, B., Park, Y. K., Piersigilli, A., Pham, T. X., Yang, Y., Siah Ku, C., Koo, S. I., Fomitchova, A., Canto, C., Schoonjans, K., Sauve, A. A., Lee, J. Y. & Auwerx, J. Eliciting the mitochondrial unfolded protein response via NAD repletion reverses fatty liver disease. Hepatology, 63, 1190-1204, (2015). 12 Spichtig, D.#, Zhang, H.#, Mohebbi, N., Pavik, I., Petzold, K., Stange, G., Saleh, L., Edenhofer, I., Segerer, S., Biber, J., Jaeger, P., Serra, A. L. & Wagner, C. A. Renal expression of FGF23 and peripheral resistance to elevated FGF23 in rodent models of polycystic kidney disease. Kidney International, 85, 1340-1350, (2014). (#, equal contribution). Chosen for perspective in Kidney international, 85, 1260-1262 and recommended in F1000 prime. 13 Ryu, D., Jo, Y. S., Lo Sasso, G., Stein, S., Zhang, H., Perino, A., Lee, J. U., Zeviani, M., Romand, R., Hottiger, M. O., Schoonjans, K. & Auwerx, J. A SIRT7-dependent acetylation switch of GABPbeta1 controls mitochondrial function. Cell Metabolism, 20, 856-869, (2014). 14 Pirinen, E., Canto, C., Jo, Y. S., Morato, L., Zhang, H., Menzies, K. J., Williams, E. G., Mouchiroud, L., Moullan, N., Hagberg, C., Li, W., Timmers, S., Imhof, R., Verbeek, J., Pujol, A., van Loon, B., Viscomi, C., Zeviani, M., Schrauwen, P., Sauve, A. A., Schoonjans, K. & Auwerx, J. Pharmacological Inhibition of Poly(ADP-Ribose) Polymerases Improves Fitness and Mitochondrial Function in Skeletal Muscle. Cell Metabolism, 19, 1034-1041, (2014).