王海河 - 中山大学 - 中山医学院

个人简介

1990年-1997年先后在西北农业大学获得学士和硕士学位。2000年7月在福建农业大学获得博士学位，师从我国著名植物病理学家谢联辉院士。2001年4月—2010年12月，曾先后在新加坡国立大学（NUS）、新加坡基因研究院(GIS)和新加坡分子与细胞研究院(IMCB)从事博士后和专职研究员工作，2011年1月回国加入中山大学中山医学院工作。

研究领域

主要研究肿瘤转移过程中相关基因在肿瘤发生、转移和癌症干细胞分化形成过程中作用的分子信号传导机制，为癌症的有效诊断和治疗奠定理论和实践基础。

近期论文

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Xu L, Zhang M, Li H, Guan W, Liu B, Liu F, Wang H, Li J, Yang S, Tong X* & Wang H* SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia.Leukemia & Lymphoma, 2017, DOI: 10.1080/10428194.2017.1344843 Tong F, Guo X, Shi H, Zhang M, Li L, Wang H*, Yang S*. Expression patterns of SH3BGR family members in zebrafish development. Development Genes and Evolution. 2016, 226(4),287-295. Liu B, Zhang M, Fang T, Yang S and Wang H*. Expression patterns and physiological roles of SH3BGR protein family as adaptor proteins. Integr Cancer Sci Therap, 2016, 3(2): 410-413. Invited review. Zhang W#, Shi H#, Zhang M, Liu B, Mao S, Li L, Tong F, Liu G, Yang S, and Wang H*. Poly C binding protein 1 represses autophagy through downregulation of LC3B to promote tumor cell apoptosis in starvation. International Journal of Biochemistry and Cell Biology, 2016,73，127-136. http://dx.doi.org/10.1016/j.biocel. 2016.02.009. IF=4.056. Li L, Shi H, Zhang M, Guo X, Tong Fang, Zhang W, Zhou J, Wang H*, and Yang S*. Upregulation of metastasis-associated PRL-3 initiates chordoma in zebrafish. International Journal of Oncology，2016, 48（4）1541-1552. IF=3.03. Wang H*, Liu B, Al-aidaroos AQ, Li L, Shi H, Guo K, Li J, Tan JP, Loo JM, Liu B, Shi H, and Zeng Q. Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans. Oncogene，2016, 35 (25): 3303-3313, online publication, doi: 10.1038/onc.2015.391. IF=8.456） Dong Q, Ding X, Chang B, Wang H, Wang A. PRL-3 promotes migration and invasion and is associated with poor prognosis in salivary adenoid cystic carcinoma. J Oral Pathol Med. 2015 Jun 3. doi: 10.1111/jop.12331. [Epub ahead of print] Chen Y, Pei H, Chang Y, Chen M, Wang H, Xie H and Yao S*. The impact of endometrioma and laparoscopic cystectomy on ovarian reserve and the exploration of related factors assessed by serum anti-Mullerian hormone: a prospective cohort study. Journal of Ovarian Research 2014, 7:108 Qu S, Liu B,Guo X, Shi H, Zhou M, Li L, Yang S, Tong X* and Wang HH*.2014. Independent oncogenic and therapeutic significance of phosphatase PRL-3 in FLT3-ITD negative acute myeloid leukemia. Cancer, 120:2130-2141 (IF=5.201) Hao Liu, Abdul Qader Al-aidaroos, Haihe Wang, Ke Guo, Jie Li, Hua Fei Zhang and Qi Zeng. 2013.PRL-3 suppresses c-Fos and integrin alpha2 expression in ovarian cancer cells. BMC Cancer. 13:80 doi:10.1186/1471-2407-13-80. Wang H.H., Vardy Leah , Tan Cheng Peow, Loo Jia Min, Guo Ke, Li Jie, Lim Seng Gee, Zhou Jianbiao, Chng Wee Joo, Ng Siok Bian, Li Hui Xiang and Zeng Qi. 2010. PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Cancer Cell, 18:52-62. Guo Ke*, Li Jie*, Tang Jing Ping*, Tan Bobby, Wang H. H., Zeng Qi. 2008. Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice.Cancer Biology& Therapy, 7(5):750-757 * Equal contribution. Wang H.H. Quah Yi Ling, Samatha, Dong Jing Ming, Manser E., Tang Jing Ping, Zeng Qi. 2007. PRL-3 downregulates PTEN expression and signals through PI3K to promote epithelial-mensenchymal transition. Cancer Res. 67 (7): 2922-2926. Guo K., Li, J., Wang H.H., Osato M., Tang J.P., Quah S.Y., Gan B.Q., and Zeng Q. 2006. PRL-3 initiates tumor angiogenesis by recruiting endothelial cells in vitro and in vivo. Cancer Res. 66: 9625-9635. Cao S. S., Wang H.H., Luhur A., and Wong S.M. 2005.Yeast expression and characterization of SARS-CoV N protein. Journal of Virological Methods, 130: 83-88. Wang H. H., H. H. Yu, and S. M. Wong. 2004. Mutation of Phe 50 to Ser 50 in the 126/183 Kilodalton proteins of Odontoglossum ringspot virusabolishes virus replication but can be restored by reversion. Journal of General Virology, 85: 2447-2457. Wang H. H. and S. M. Wong. 2004. Significance of 3’-terminal region in minus-strand synthesis of Hibiscus chlorotic ringspot virus. Journal of General Virology, 85: 1763-1776.