李勃兴 - 中山大学 - 中山医学院

个人简介

李勃兴博士本科毕业于原第一军医大学临床医学专业，后师从我国著名神经生物学者高天明教授获得神经生物学硕士及博士学位。2012年至2016年在美国纽约大学完成博士后培训，合作导师为国际著名神经科学家Richard Tsien（钱永佑）教授。

研究领域

李勃兴教授课题组致力于揭示认知和情感等高级神经功能的分子机制，并探索自闭症及神经退行性疾病等神经/精神疾病的发病机制；研究方向包括：1）离子通道及下游信号通路在认知功能中的作用；2）自闭症及认知功能障碍的发病机制；3）神经科学新技术开发。

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

1. Boxing Li#, Michael R. Tadross#*, Richard W. Tsien. Sequential ionic and conformational signaling by calcium channels drives neuronal gene expression. Science 2016, 351(6275), 863-86 (# equal contribution) (Editor's Choice in Science Signaling; Paper of Note in Science. F1000 recommendation) 2. Boxing Li, Wei Jie, Lianyan Huang, Peng Wei, Shuji Li, Zhengyi Luo, Allyson K. Friedman, Andrea L. Meredith, Ming-Hu Han, Xin-Hong Zhu, Tian-Ming Gao*. Nuclear BK channels regulate gene expression via the control of nuclear calcium signaling. Nature Neuroscience 2014, 17(8):1055-63 3. Lianyan Huang#, Boxing Li#, Shihao Tang, Hongbo Guo, Wenjun Li, Xiaozhou Huang, Wenjuan Yan, Fei Zou*. Mitochondrial KATP Channels Control Glioma Radioresistance by Regulating ROS-Induced ERK Activation. Molecular Neurobiology 2015, 52(1):626-37. (# equal contribution) 4. Lianyan Huang#, Boxing Li#, Wenjun Li, Hongbo Guo Fei Zou* ATP-sensitive potassium channels control glioma cells proliferation by regulating ERK activity. Carcinogenesis 2009, 30(5):737–744. (# equal contribution) 5. Huan Ma*, Rachel Groth, Samuel Cohen, John Emery, Boxing Li, Esthelle Hoedt,Guoan Zhang, Thomas Neubert, Richard Tsien*, γCaMKII shuttles Ca2+/CaM to the nucleus to trigger CREB phosphorylation and gene expression. Cell 2014, 159: 281–294 (Preview in: Mission CaMKIIγ: Shuttle Calmodulin from Membrane to Nucleus. Cell 2014,159: 235–237) 6. Huan Ma*, Boxing Li, Richard Tsien* Distinct roles of multiple isoforms of CaMKII in signaling to the nucleus. Biochim Biophys Acta. 2015, 17. pii: S0167-4889(15) 7. Samuel Cohen, Boxing Li, Richard W. Tsien, Huan Ma*. Evolutionary and functional perspectives on signaling from neuronal surface to nucleus. Biochem Biophys Res Commun. 2015, 24; 460 (1):88-99. 8. Huan Ma, Samuel Cohen, Boxing Li and Richard W. Tsien*. Exploring the dominant role of Cav1 channels in signaling to the nucleus. Bioscience Reports. 2012, 20(33):97-101. 9. Ming Chen, Hongyu Sun, Ping Hu, Chunfei Wang, Boxing Li, Shuji Li, Jianjun Li, Huiying Tan, Tian-Ming Gao*. Activation of BKca channels mediates hippocampal neuronal death after reoxygenation and reperfusion. Molecular Neurobiology 2013, 48(3):794-807 10. Zhao ST, Chen M, Li SJ, Zhang MH, Boxing Li, Das M, Bean JC, Kong JM, Zhu XH, Gao TM* (2009) Mitochondrial BNIP3 upregulation precedes endonuclease G translocation in hippocampal neuronal death following oxygen-glucose deprivation. BMC Neuroscience 8;10:113(p1-8) 11. Lianyan Huang, Wenjun Li, Boxing Li, Fei Zou*. Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. Neuroscience Letters 2006,398:34–38. BOOK CHAPTERS: 12. Boxing Li, Tian-Ming Gao* Functional Role of Mitochondrial and Nuclear BK channels. In: Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels. International Review of Neurobiology. 2016,128:163-191