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个人简介

教育经历: 2002/09-2006/06,中山大学,生命科学学院生物科学与技术系,生物科学专业,理学学士学位 2006/09-2011/06,中山大学,生命科学学院生物化学系,生物化学与分子生物学专业,理学博士学位 工作经历: 2011/09-2017/02,美国南加州大学,微生物分子学与免疫学系,研究助理(博士后) 2017/02至今,中山大学,生命科学学院,副教授

研究领域

肿瘤发生发展的分子机制; 非编码RNA功能; 肿瘤代谢调控网络。

近期论文

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[1]Xu T, Zhu Y, Xiong Y, Ge YY, Yun JP, Zhuang SM. MicroRNA-195 suppresses tumorigenicity and regulates G1/S transition of human hepatocellular carcinoma cells, Hepatology. 2009 Jul;50(1):113-2(共同第一作者)(IF: 13.246) [2]Zhu Y, Lu Y, Zhang Q, Liu JJ, Li TJ, Yang JR, Zeng C, Zhuang SM. MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein, Nucleic Acids Res. 2012 May;40(10):4615-25. (IF: 10.162) [3]Lei X, Zhu Y, Jones T, Bai Z, Huang Y, Gao SJ. A Kaposi's sarcoma-associated herpesvirus microRNA and its variants target the transforming growth factor β pathway to promote cell survival, J Virol. 2012 Nov;86(21):11698-711. (共同第一作者)(IF: 4.663) [4]Zhu Y, Haecker I, Yang Y, Gao SJ, Renne R. γ-Herpesvirus-encoded miRNAs and their roles in viral biology and pathogenesis, Curr Opin Virol. 2013 Jun;3(3):266-75. (IF: 5.067) [5]Zhu Y, Huang YF, Jung JU, Lu C, Gao SJ. Viral miRNA targeting of bicistronic and polycistronic transcripts. Curr Opin Virol. 2014 Aug; 7:66-72. (IF: 5.067) [6]Zhu Y, Ramos da Silva S, He M, Liang Q, Lu C, Feng P, Jung JU, Gao SJ. An oncogenic virus promotes cell survival and cellular transformation by suppressing glycolysis. PLoS Pathog. 2016 May;12(5): e1005648. (IF: 6.608) [7]Zhu Y, Li T, Ramos da Silva S, Lee JJ, Lu C, Eoh H, Jung JU, Gao SJ. A critical role of glutamine and asparagine γ-nitrogen in nucleotide biosynthesis in cancer cells hijacked by an oncogenic virus. MBio. 2017 Aug 15;8(4). pii: e01179-1 (IF: 6.956) [1]Xu T, Zhu Y, Wei QK, Yuan Y, Zhou F, Ge YY, Yang JR, Su H, Zhuang SM. A functional polymorphism in the miR-146a gene is associated with the risk for hepatocellular carcinoma, Carcinogenesis. 2008 Nov;29(11):2126-31. (IF: 5.105) [2]Moody R, Zhu Y, Huang Y, Cui X, Jones T, Bedolla R, Lei X, Bai Z, Gao SJ. KSHV microRNAs mediate cellular transformation and tumorigenesis by redundantly targeting cell growth and survival pathways, PLoS Pathog. 2013 Dec;9(12):e1003857. (IF: 6.608) [3]Bai Z, Huang Y, Li W, Zhu Y, Jung JU, Lu C, Gao SJ. Genomewide mapping and screening of Kaposi's Sarcoma-Associated Herpesvirus (KSHV) 3' untranslated regions identify bicistronic and polycistronic viral transcripts as frequent targets of KSHV microRNAs, J Virol. 2014 Jan;88(1):377-92. (IF: 4.663) [4]Zhao N, Wang R, Zhou L, Zhu Y, Gong J, Zhuang SM. MicroRNA-26b suppresses the NF-κB signaling and enhances the chemosensitivity of hepatocellular carcinoma cells by targeting TAK1 and TAB3. Mol Cancer. 2014 Feb 24;13:35. (IF: 6.204) [5]Lee MS, Yuan H, Jeon H, Zhu Y, Yoo S, Shi S, Krueger B, Renne R, Lu C, Jung JU, Gao SJ. Human Mesenchymal Stem Cells of Diverse Origins Support Persistent Infection with Kaposi’s Sarcoma-Associated Herpesvirus and Manifest Distinct Angiogenic, Invasive, and Transforming Phenotypes. MBio. 2016 Jan 26;7(1):e02109-1 (IF: 6.956) [6]Li W, Yan Q, Ding X, Shen C, Hu M, Zhu Y, Qin D, Lu H, Krueger BJ, Renne R, Gao SJ, Lu C. The SH3BGR/STAT3 Pathway Regulates Cell Migration and Angiogenesis Induced by a Gammaherpesvirus MicroRNA, PLoS Pathog. 2016 Apr 29;12(4):e1005605. (IF: 6.608)

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