郑凌伶 - 中山大学 - 生命科学学院

个人简介

2017.01-至今中山大学生命科学学院副教授 2012.07-2016.12 中山大学生命科学学院讲师 2009.09-2012.06 中山大学生命科学学院生物化学与分子生物学博士（导师屈良鹄教授） 2006.09-2009.06 中山大学生命科学学院信息生物学硕士（导师王珣章教授） 2002.09-2006.06 东北林业大学计算机系本科

研究领域

功能基因组学与生物信息学非编码RNA调控网络与重大疾病高通量测序数据分析与应用

近期论文

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Ling-Ling Zheng, Ke-Ren Zhou, Shun Liu, Ding-Yao Zhang, Ze-Lin Wang, Zhi-Rong Chen, Jian-Hua Yang, Liang-Hu Qu. dreamBase: DNA modification, RNA regulation and protein binding of expressed pseudogenes in human health and disease. Nucleic Acids Res. 2017 Oct 20. doi: 10.1093/nar/gkx972. Ling-Ling Zheng, Kai-Wen Deng, An-Cheng Deng, Jie Wu, Jian-Hua Yang, Zhao-Rong Lun, Liang-Hu Qu. Exo-miRExplorer: A Comprehensive Resource for Exploring and Comparatively Analyzing Exogenous MicroRNAs. Front Microbiol. 2017 Feb 1;8:126. doi: 10.3389/fmicb.2017.00126.PubMed PMID: 28203233. Ling-Ling Zheng, Wei-Lin Xu, Shun Liu, Wen-Ju Sun, Jun-Hao Li, Jie Wu, Jian-Hua Yang, Liang-Hu Qu. tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers. Nucleic Acids Res. 2016 May 13. pii: gkw414. Ling-Ling Zheng, Jun-Hao Li, Jie Wu, Wen-Ju Sun, Shun Liu, Ze-lin Wang, Hui Zhou, Jian-Hua Yang and Liang-Hu Qu. deepBase v2.0: Identification, Expression, Evolution and Function of Small RNAs, LncRNAs and Circular RNAs from Deep-sequencing Data. Nucleic Acids Res. 2015 Nov 20. pii: gkv1273. （ESI高被引论文） Ling-Ling Zheng and Liang-Hu Qu. Application of microRNA gene resources in the improvement of agronomic traits in rice. Plant Biotechnol J. 2015 Apr;13(3):329-36. Ling-Ling Zheng, Yan-Zi Wen, Jian-Hua Yang, Jian-You Liao, Peng Shao, Hui Xu, Hui Zhou, Jun-Zhi Wen, Zhao-Rong Lun, Francisco J Ayala and Liang-Hu Qu. Comparative transcriptome analysis of small noncoding RNAs in different stages of Trypanosoma brucei. RNA. 2013 Jul;19(7):863-75. Yan-Zi Wen1, Ling-Ling Zheng1 （共同第一作者）, Jian-You Liao, Ming-Hui Wang, Yin Wei, Xue-Min Guo, Liang-Hu Qu, Francisco J. Ayala, and Zhao-Rong Lun. Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8345-50. Ling-Ling Zheng and Liang-Hu Qu. Computational RNomics: structure identification and functional prediction of non-coding RNAs in silico. Science China Life Sciences. 2010 May.53(5):548-62. Jun-Hao Li1, Sun Liu1, Ling-Ling Zheng1 （共同第一作者）, Jie Wu, Wen-Ju Sun, Ze-Lin Wang, Hui Zhou, Liang-Hu Qu, Jian-Hua Yang. Discovery of Protein-lncRNA Interactions by Integrating Large-Scale CLIP-Seq and RNA-Seq Datasets. Front Bioeng Biotechnol. 2015 Jan 14;2:88. Wei-Lin Xu, Ye Yang, Yi-Dan Wang, Liang-Hu Qu and Ling-Ling Zheng（通讯作者）. Computational Approaches to tRNA-Derived Small RNAs. Non-Coding RNA 2017, 3(1), 2; Yan-Zi Wen, Ling-Ling Zheng, Liang-Hu Qu, Francisco J Ayala and Zhao-Rong Lun. Pseudogenes are not pseudo any more[J]. RNA Biology. 2012, 9(1): 27–32. Jian-You Liao, Yan-Hua Guo, Ling-Ling Zheng, Yan Li, Wen-Li Xu, Yu-Chan Zhang, Hui Zhou, Zhao-Rong Lun, Francisco Ayala, Liang-Hu Qu,. Both endo-siRNAs and tRNA-derived small RNAs are involved in the differentiation of primitive eukaryote Giardia lamblia. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14159-64. Sun Yat Sen Univ, Sch Life Sci, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China. Zhao-Rong Lun, De-Hua Lai, Yan-Zi Wen, Ling-Ling Zheng, Ji-Long Shen, Ting-Bo Yang, Wen-Liang Zhou, Liang-Hu Qu, Geoff Hide and Francisco J. Ayala. Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proc Natl Acad Sci U S A. 2015 Jul 21;112(29):8835-42. Ruo-Hong Lin, De-Hua Lai, Ling-Ling Zheng, Jie Wu, Julius Lukeš, Geoff Hide, Zao-Rong Lun. Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasit Vectors. 2015 Dec 30;8:665. Yi-Jun Zhang, Jian-Hua Yang, Qiao-Su Shi, Ling-Ling Zheng, Jun Liu, Hui Zhou, Hui Zhang, Liang-Hu Qu. Rapid Birth-and-Death Evolution of Imprinted snoRNAs in the Prader-Willi Syndrome Locus: Implications for Neural Development in Euarchontoglires. PLoS One. 2014 Jun 19;9(6):e100329.