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个人简介

1979—1984年 上海医科大学医学系医学专业 1984—1990年 上海医科大学附属华山医院医生 1990—1994年 荷兰Leiden大学免疫学专业博士生 1994—1996年 瑞典Linkoping大学医学院细胞生物系博士后 1996—1998年 瑞典Lund大学附属Malmo总医院博士后 1999—2002年 瑞典Linkoping大学医学院医学微生物系助理教授 2002—2016年 中山大学生命科学学院教授,博士生导师 2016年-- 中山大学生命科学学院院长 1984年毕业于上海医科大学并在附属华山医院感染科任临床医生(师从翁心华教授);1994年获荷兰Leiden 大学免疫学博士学位;1994年11月至1998年,在瑞典Linkoping大学医学院和Lund大学附属Malmo总医院 做博士后;1999年被瑞典国家医学基金会(MFR/VR)聘为助理教授 ;2002年9月回国任中山大学教授;2007年6月起兼任中山大学肿瘤防治中心教授

研究领域

肿瘤免疫,免疫细胞生物学

近期论文

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DP Chen, WR Ning, XF Li, Y Wei, XM Lao, JC Wang, Y Wu and L Zheng. Peritumoral monocytes induce cancer cell autophagy to facilitate the progression of human hepatocellular carcinoma. Autophagy, 2018, in press YM Meng, J Liang, C Wu, J Xu, DN Zeng, XJ Yu, H Ning, L Xu, and L Zheng. Monocytes /Macrophages promote vascular CXCR4 expression via the ERK pathway in hepatocellular carcinoma. OncoImmunology 2018, 7(3): e1408745 J Xu, J Liang, YM Meng, J Yan, XJ Yu, CQ Liu, L Xu, SM Zhuang and L Zheng. Vascular CXCR4 expression promotes vessel sprouting and sensitivity to Sorafenib treatment in hepatocellular carcinoma. Clin. Cancer Res. 2017, 23(15): 4482-4492 J Zhang, J Xu, RX Zhang, Y Zhang, QJ Ou, JQ Li, ZZ Jiang, XJ Wu, YJ Fang, and L Zheng. CD169 identifies an activated CD8 T cell subset in regional lymph nodes that predicts favorable prognosis in colorectal cancer patients. Oncoimmunology 2016, 5(7): e1177690 Y Zhang, JQ Li, ZZ Jiang, L Li, Y Wu, and L Zheng. CD169 identifies an anti-tumour macrophage subpopulation in human hepatocellular carcinoma. J. Pathol. 2016, 239:231-41 L Zhao, Y Wu, XD Xie, YF Chu, JQ Li, and L Zheng. c-Met identifies a population of matrix metalloproteinase 9-producing monocytes in peritumoral stroma of Hepatocellular carcinoma. J. Pathol. 2015, 237:319-29. XF Li, DP Chen, FZ Ouyang, MM Chen, Y Wu, DM Kuang, and L Zheng. Increased autophagy sustains the survival and protumorigenic effects of neutrophils in human cancers. J. Hepatol. 2015, 62: 131–9. (Recommended by F1000) DM Kuang, X Xiao, Q Zhao, MM Chen, XF Li, RX Liu, Y Wei, FZ Ouyang, DP Chen, Y Wu, XM Lao, H Deng, and L Zheng. B7-H1-expressing antigen-presenting cells mediate polarization of pro-tumorigenic Th22 subset. J. Clin. Invest. 2014, 124:4657–67 (Recommended by F1000) WC Wu, HW Sun, HT Chen, J Liang, XJ Yu, C Wu, Z Wang, and L Zheng. Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients. Proc. Natl. Acad. Sci. USA. 2014, 111: 4221–6. Y Wu, DM Kuang, WD Pan, YL Wan, XM Lao, D Wang, XF Li, L Zheng. Monocyte /Macrophage-elicited NK cell dysfunction in Hepatocellular carcinoma is mediated by CD48/2B4 interactions. Hepatology, 2013; 57:1107-16. J Xu, T Ding, Q He, X Yu, W Wu, W Jia, J Yun, Y Zhang, M Shi, C Shao, WD Pan, X Yin, J Min, SM Zhuang, L Zheng. In Situ molecular signature predict early recurrence in Hepatitis B virus-related hepatocellular carcinoma. J. Hepatol. 2012; 57: 313-21. Q Zhao, DM Kuang, Y Wu, X Xiao, X Li, T Li, L Zheng. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J. Immunol. 2012; 188:1117-24. DM Kuang, Q Zhao, Y Wu, C Peng, J Wang, Z Xu, X Yin, L Zheng. Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma. J. Hepatol. 2011; 54:948-55. (Highly cited paper based on ESI) DM Kuang, C Peng, Q Zhao, Y Wu, LY Zhu, J Wang, XY Yin, L Li, L Zheng. Tumor activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients. J. Immunol. 2010; 185:1544-9. DM Kuang, C Peng, Q Zhao, Y Wu, MS Chen, L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory Th17 cells. Hepatology, 2010, 51:154-64 JP Zhang, J Yan, J Xu, XH Pang, MS Chen, L Li, C Wu, SP Li, L Zheng. Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients. J. Hepatol. 2009; 50:980-9. (Highly cited paper based on ESI) J Zhou, T Ding, LY Zhu, W Pan, L Li, L Zheng. Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int. J. Cancer. 2009; 125:1640-8. DM Kuang, QY Zhao, C Peng, J Xu, JP Zhang, L Zheng. Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1. J. Exp. Med. 2009; 206: 1327-37.

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