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个人简介

教育经历: 1999.09~2003.07: 中山大学,生命科学学院生物化学系,理学学士 2003.09~2008.06: 中山大学,生命科学学院生物化学系, 理学博士 2007.10~2008.04: 美国 Scripps institution of oceanography, University of California,San Diego(美国加州大学圣地亚哥分校 Scripps 海洋研究所),访问学者 工作经历: 2008.07~2010.12: 中山大学,海洋生物学博士后流动站,博士后 2011.01~2015.12: 中山大学,生命科学学院生物化学系,副教授 2016.01~今: 中山大学,生命科学学院生物化学系,教授

研究领域

分子免疫学;比较免疫学

近期论文

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1. Huang S#, Tao X#, Yuan S#, Zhang Y, Li P, Beilinson HA, Zhang Y, Yu W, Pontarotti P, Escriva H, Le Petillon Y, Liu X, Chen S, Schatz DG, Xu A. Discovery of an active RAG transposon illuminates the origins of V(D)J recombination. Cell, 2016. 166: 102-114. 2. Jia X#, Yuan S#, Wang Y#, Fu Y, Ge Y, Ge Y, Lan X, Feng Y, Qiu F, Li P1, Chen S, Xu A. The role of alternative polyadenylation in the antiviral innate immune response. Nat Commun, 201724:14605-14617. 3. Yuan S#, Zheng T#, Li P, Yang R, Ruan J, Huang S, Wu Z, Xu A. Characterization of Amphioxus IFN Regulatory Factor Family Reveals an Archaic Signaling Framework for Innate Immune Response. J Immunol. 2015. 195:5657-5666. 4. Peng J, Tao X, Li R, Hu J, Ruan J, Wang R, Yang M, Yang R, Dong X, Chen S, Xu A*, Yuan S*, Novel Toll/IL-1 Receptor Homologous Region Adaptors Act as Negative Regulators in Amphioxus TLR Signaling. J Immunol, 2015. 195: 3110-3118. 5. Yuan S, Ruan J, Huang S, Chen S, Xu A. Amphioxus as a model for investigating evolution of the vertebrate immune system. Dev Comp Immunol, 2015. 48:297-305. 6. Yuan S, Tao X, Huang S, Chen S, Xu A. Comparative immune systems in animals. Annu. Rev. Anim. Biosci, 2014. 2:235–258. 7. Yuan S#, Dong X#, Tao X, Xu L, Ruan J, Peng J, Xu A. Emergence of the A20/ABIN-mediated inhibition of NF-kappaB signaling via modifying the ubiquitinated proteins in a basal chordate. Proc Natl Acad Sci U S A, 2014. 111: 6720-6725. 8. Yuan S, Zhang J, Zhang L, Huang L, Peng J, Huang S, Chen S, Xu A. The archaic roles of the amphioxus NF-κB/IκB complex in innate immune responses. J Immunol, 2013. 191:1220-1230. 9. Yang M#, Yuan S#, Huang S, Li J, Xu L, Huang H, Tao X, Peng J, Xu A. Characterization of bbtTICAM from amphioxus suggests the emergence of a MyD88-independent pathway in basal chordates. Cell Res, 2011. 21: 1410-1423. 10. Xu L#, Yuan S#, Li J, Huang S, Ruan J, Yang M, Huang H, Chen S, Ren Z, Xu A. The conservation and uniqueness of the Caspase family in the basal chordate amphioxus. BMC Biol, 2011.9:60. 11. Li J#, Yuan S#, Qi L, Huang S, Huang G, Yang M, Xu L, Li Y, Zhang R, Yu Y, Chen S, Xu A. Functional conservation and innovation of amphioxus RIP1-mediated signaling in cell fate determination. J Immunol, 2011. 187:3962-3971. 12. Yuan S, Liu H, Gu M, Xu L, Huang S, Ren Z, Xu A. Characterization of the extrinsic apoptotic pathway in the basal chordate amphioxus. Sci. Signal, 2010. 3, ra66. (入选2010 中国高校十大科技进展) 13.Yuan S#, Wu K#, Yang M, Xu L, Huang L, Liu H, Tao X, Huang S, Xu A. Amphioxus SARM involved in neural development may function as a suppressor of TLR signaling. J Immunol, 2010. 184:6874-6881. 14. Yuan S, Liu T, Huang S, Wu T, Huang L, Liu H, Tao X, Yang M, Wu K, Yu Y, Dong M, Xu A. Genomic and functional uniqueness of the TNF receptor-associated factor gene family in amphioxus, the basal chordate. J Immunol, 2009. 183: 4560-4568. 15. Yuan S#, Huang S#, Zhang W, Wu T, Dong M, Yu Y, Liu T, Wu K, Liu H, Yang M, Zhang H, Xu A. An amphioxus TLR with dynamic embryonic expression pattern responses to pathogens and activates NF-kappaB pathway via MyD88. Mol Immunol, 2009. 46:2348-2356. 16.Yuan S, Yu Y, Huang S, Liu T, Wu T, Dong M, Chen S, Yu Y, Xu A. Bbt-TNFR1 and Bbt- TNFR2, two tumor necrosis factor receptors from Chinese amphioxus involve in host defense. MolImmunol, 2007. 44:756-762.

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