杨建华 - 中山大学 - 生命科学学院

个人简介

教育经历： 1. 2003/9–2008/7，中山大学，生物化学与分子生物学，博士，导师：屈良鹄 2. 1998/9–2002/7，西南农业大学（现西南大学），生物科学与农学，学士工作经历： 1. 2016/1-至今，中山大学，生命科学学院，教授 2. 2011/1-2015/12，中山大学，生命科学学院，副教授 3. 2008/7-2010/12，中山大学，生命科学学院，讲师（师资博士后）

研究领域

1、开发基于新一代测序技术（NGS）的新算法和实验方法解码非编码RNA基因的功能和调控网络 2、整合高通量癌症基因组数据结合实验研究非编码RNA在疾病发生发展中的作用 3、开发表观转录组学的分析和实验方法研究RNA修饰的功能和机制

近期论文

查看导师新发文章（温馨提示：请注意重名现象，建议点开原文通过作者单位确认）

Huang H+, Weng H+, Sun W+, Qin X+, Shi H+, Wu H, Zhao BS, Mesquita A, Liu C, Yuan CL, Hu YC, Hüttelmaier S, Skibbe JR, Su R, Deng X, Dong L, Sun M, Li C, Nachtergaele S, Wang Y, Hu C, Ferchen K, Greis KD, Jiang X, Wei M, Qu L, Guan JL, He C*, Yang J*, Chen J*. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat Cell Biology. 2018 Mar;20(3):285-295. (* Correspondence Author, +Co-first author) ESI Highly Cited Paper, News & Views in Nat Cell Biology. Qu L+, Wang ZL+, Chen Q+, Li YM+, He HW, Hsieh JJ, Xue S, Wu ZJ, Liu B, Tang H, Xu XF, Xu F, Wang J, Bao Y, Wang AB, Wang D, Yi XM, Zhou ZK, Shi CJ, Zhong K, Sheng ZC, Zhou YL, Jiang J, Chu XY, He J, Ge JP, Zhang ZY, Zhou WQ*, Chen C*, Yang JH*, Sun YH*, Wang LH*. Prognostic Value of a Long Non-coding RNA Signature in Localized Clear Cell Renal Cell Carcinoma. European Urology 2018 Aug 21. 10.1016/j.eururo.2018.07.032. (* Correspondence Author, +Co-first author) Highlight in European Urology Bao X, Guo X, Yin M, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, Li N, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, Zhang C, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B, Esteban MA. Capturing the interactome of newly transcribed RNA. Nat Methods. 2018 Mar;15(3):213-220. Weng H, Huang H, Wu H, Qin X, Zhao BS, Dong L, Shi H, Skibbe J, Shen C, Hu C, Sheng Y, Wang Y, Wunderlich M, Zhang B, Dore LC, Su R, Deng X, Ferchen K, Li C, Sun M, Lu Z, Jiang X, Marcucci G, Mulloy JC, Yang J, Qian Z, Wei M, He C, Chen J. METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m(6)A Modification. Cell Stem Cell.2018 Feb 1;22(2):191-205.ESI Highly Cited Paper, Highlight in Cell Stem Cell. Wang ZL+, Li B+, Luo YX, Lin Q, Liu SR, Zhang XQ, Zhou H, Yang JH*, Qu LH*. Comprehensive Genomic Characterization of RNA-Binding Proteins across Human Cancers. Cell Reports. 2018 Jan 2;22(1):286-298. (* Correspondence Author, +Co-first author) Zheng LL+, Zhou KR+, Liu S, Zhang DY, Wang ZL, Chen ZR, Yang JH*, Qu LH*. dreamBase: DNA modification, RNA regulation and protein binding of expressed pseudogenes in human health and disease. Nucleic Acids Res. 2018 Jan 4;46(D1):D85-D91. (* Correspondence Author, +Co-first author) Xuan JJ, Sun WJ, Lin PH, Zhou KR, Liu S, Zheng LL, Qu LH*, Yang JH*. RMBase v2.0: deciphering the map of RNA modifications from epitranscriptome sequencing data. Nucleic Acids Res. 2018 Jan 4;46(D1):D327-D334. (* Correspondence Author) Zhang XQ*+, Wang ZL+, Poon MW+, Yang JH*. Spatial-temporal transcriptional dynamics of long non-coding RNAs in human brain. Hum Mol Genet. 2017 Aug 15;26(16):3202-3211.(* Correspondence Author, +Co-first author) Zheng LL, Deng KW, Deng AC, Wu J, Yang JH, Lun ZR, Qu LH. Exo-miRExplorer: A Comprehensive Resource for Exploring and Comparatively Analyzing Exogenous MicroRNAs. Front Microbiol. 2017 Feb 1;8:126. Zhou KR, Liu S, Sun WJ, Zheng LL, Zhou H, Yang JH*, Qu LH*. ChIPBase v2.0: decoding transcriptional regulatory networks of non-coding RNAs and protein-coding genes from ChIP-seq data. Nucleic Acids Res. 2017 Jan 4;45(D1):D43-D50. (* Correspondence Author)ESI Highly Cited Paper Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, Yang JH, Liu J, Drakos SG, Selzman CH, Kyselovic J, Qu LH, Dos Remedios CG, Pu WT, Wang DZ. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. Cardiovasc Res. 2016 Aug 24. pii: cvw201. Guo YH, Wang LQ, Li B, Xu H, Yang JH, Zheng LS, Yu P, Zhou AD, Zhang Y, Xie SJ, Liang ZR, Zhang CM, Zhou H, Qu LH. Wnt/β-catenin pathway transactivates microRNA-150 that promotes EMT of colorectal cancer cells by suppressing CREB signaling. Oncotarget. 2016 Jul 5;7(27):42513-4252 Zheng LL, Xu WL, Liu S, Sun WJ, Li JH, Wu J, Yang JH*, Qu LH*. tRF2Cancer: A web server to detect tRNA-derived small RNA fragments (tRFs) and their expression in multiple cancers. Nucleic Acids Res. 2016 Jul 8;44(W1):W185-93. (* Correspondence Author) Wang ZL+, Li B,+ Piccolo SR, Zhang XQ, Li JH, Zhou H, Yang JH*, Qu LH*. Integrative analysis reveals clinical phenotypes and oncogenic potentials of long non-coding RNAs across 15 cancer types. Oncotarget. 2016 Jun 7;7(23):35044-55. (* Correspondence Author,+Co-first author) Zheng LL, Li JH, Wu J, Sun WJ, Liu S, Wang ZL, Zhou H, Yang JH*, Qu LH*. deepBase v2.0: identification, expression, evolution and function of small RNAs, LncRNAs and circular RNAs from deep-sequencing data. Nucleic Acids Res. 2016 Jan 4;44(D1):D196-202. (* Correspondence Author) ESI Highly Cited Paper Sun WJ, Li JH, Liu S, Wu J, Zhou H, Qu LH*, Yang JH*. RMBase: a resource for decoding the landscape of RNA modifications from high-throughput sequencing data. Nucleic Acids Res. 2016 Jan 4;44(D1):D259-65. (* Correspondence Author)ESI Highly Cited Paper