徐卫华 - 中山大学 - 生命科学学院

个人简介

1982.8-1983. 8, 就职于浙江省长兴县农业局, 技术员；1986.8-1991.10, 就职于中国农业科学院蚕业研究所, 助理研究员；1995.4-2005.12, 就职于中国科技大学生命科学学院，副教授、教授。2001.11-2002.11 在美国 Ohio State University 昆虫系作访问学者；2006.1- 现在就职于中山大学生命科学学院。现任Journal of Insect Physiology编委，昆虫学报副主编。中国科学院动物所虫鼠害综合防治国家重点实验室学术委员会委员, 中国科学院上海植生所昆虫发育与进化生物学实验室学术委员会委员, 农业部蚕桑遗传改良重点实验室学术委员会委员，江苏省蚕桑生物学与生物技术重点实验室学术委员会委员，广东省动物保护与资源利用重点实验室学术委员会委员。

研究领域

昆虫发育的基因调节以农业害虫棉铃虫作为研究对象，围绕发育的激素和基因调节机制开展工作，试图阐明重要或关键基因如何调节昆虫发育以及相关的信号调节路径如何cross-talk 控制发育的机制。

近期论文

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[1] Zhang X-S., Wang T., Lin X-W., Denlinger DL*., Xu W-H*. Reactive oxygen species regulate insect lifespan using components of the insulin signaling pathway. Proc. Natl. Acad. Sci. USA. 2017. 114(37):E7832-E7840. [2] Li H-Y#, Wang T#., Yang Y-P., Geng S-L., Xu W-H*. TGF-β signaling regulates p-Akt levels via PP2A during diapause entry in the cotton bollworm, Helicoverpa armigera. Insect Biochemistry and Molecular Biology. 2017. 87:165-173, [3] Yang C#., Lin X-W#., Xu W-H*. Cathepsin L participates in the remodeling of the midgut through dissociation of midgut cells and activation of apoptosis via caspase-1. Insect Biochemistry and Molecular Biology. 2017. 82:21-30. [4] Lin X-W. Tang L., Yang J.-H., Xu W-H*. HIF-1 regulates insect lifespan extension by inhibiting c-Myc-TFAM signaling and mitochondrial biogenesis. Biochim. Biophys. Acta-Molecular Cell Research, 2016, 1863,2594-2603. [5] Lin X-W. and Xu W-H*. Hexokinase is a key regulator of energy metabolism and ROS activity in insect lifespan extension. Aging-US. 2016. 8(2):245-259. [6] Chen W. Xu W.-H*. Wnt/-catenin signaling regulates Helicoverpa armigera pupal development by up-regulating c-Myc and AP-4. Insect Biochemistry and Molecular Biology. 2014. 53:44-53. [7] Lu Y-X., Denlinger DL., Xu W.-H*. Polycomb repressive complex 2 (PRC2) protein ESC regulates insect development by mediating H3K27me3 and promoting PTTH gene expression. J. Biol. Chem. 2013, 288(32):23554-23564. [8] Zhang Y., Lu Y.-X., Liu J., Yang C., Feng Q.-L., Xu W.-H*. A regulatory pathway, ecdysone-transcription factor Relish- cathepsin L, is involved in insect fat body dissociation. PLoS Genetics 2013. 9(2): e1003273. Doi:10.1371/journal.pgen.1003273. [9] Xu W.-H*., Lu Y.-X., Denlinger D.L*. Cross-talk between the fat body and brain regulates insect developmental arrest. Proc. Natl. Acad. Sci. USA. 2012.109(36):14687-14692. [10] Zhang Q., Lu Y.-X., Xu W.-H*. Integrated proteomic and metabolomic analysis of the larval brain associated with diapause induction and preparation in the cotton bollworm, Helicoverpa armigera, Journal of Proteome Research, 2012.11:1042-1053 [11] Bao B., Feng Q.L., Xu W-H*. Transcription factor fork head regulates the promoter of diapause hormone gene in the cotton bollworm, Helicoverpa armigera, and the modification of SUMOylation. Insect Biochemistry and Molecular Biology. 2011, 41(9): 670-679. [12] Bao B., Xu W.-H*. Identification of gene expression changes associated with the initiation of diapause in the brain of the cotton bollworm, Helicoverpa armigera. BMC Genomics 2011.12:224. [13] Lv Y-X., Xu W-H*. Proteomic and phosphoproteomic analysis at diapause initiation in the cotton bollworm, Helicoverpa armigera, Journal of Proteome Research, 2010, 9(10):5053-5064. [14] Hu C-H., Hong B., Xu W-H*. Identification of an E-box DNA binding protein AP-4 and its function in regulating the expression of the gene encoding diapause hormone and pheromone biosynthesis activating neuropeptide in Helicoverpa armigera. Insect Molecular Biology. 2010, 19(2):243-252.