沈侠 - 中山大学 - 生命科学学院

个人简介

2007 年本科毕业于中国人民大学统计学院，2012 年于瑞典乌普萨拉大学(Uppsala University)获得生物信息学博士学位，主要贡献于数量遗传学的统计学方法创新研究与基因组大数据分析。在入职中山大学生命科学学院前，曾任英国爱丁堡大学 (University of Edinburgh) 和瑞典卡罗琳斯卡医学院 (Karolinska Institutet) 两所世界知名院校助理教授兼博士生导师。研究成果发表于 Nature Genetics、Nature Communications、American Journal of Human Genetics、PLoS Genetics 等国际知名期刊，受到生物统计与统计遗传学领域的高度认可，曾在海外主持并获得了多项有国际竞争力的科研经费支持。在中山大学生命科学学院继续开展广泛的国际国内交叉学科合作，致力于从多种生物组学大数据分析中挖掘出新颖且具有高影响力的研究成果。

研究领域

Statistical Omics, Quantitative Genetics, High-throughput Big Data Analysis, Bioinformatics

近期论文

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Nowak C, Hetty S, Salihovic S, Castillejo-Lopez C, Ganna A, Cook N, Broeckling CD, Prenni J, Shen X, Giedraitis V, Ärnlöv J, Lind L, Berne C, Sundström J, Fall T, Ingelsson E (2018): Glucose challenge metabolomics implicates medium-chain acylcarnitines in insulin resistance. Scientific Reports, in press. Li X, Meng X, Spiliopoulou A, Timofeeva M, Wei W-Q, Gifford A, Shen X, He Y, Varley T, Tzoulaki I, Wright AF, Denny JC, Campbell H, Theodoratou E (2018): MR-PheWAS: exploring the causal effect of SUA level on multiple disease outcomes by using genetic instruments in UK Biobank. Annals of the Rheumatic Diseases, online first. DOWNLOAD Ning Z, Lee Y, Joshi PK, Wilson JF, Pawitan Y, Shen X (2017): A selection operator for summary association statistics reveals allelic heterogeneity of complex traits. American Journal of Human Genetics, 101(6): 903-912; doi: 10.1016/j.ajhg.2017.09.027. DOWNLOAD Joshi PK, Pirastu N, Kentistou KA, Fischer K, Hofer E, Schraut KE, Clark DW, Nutile T, Barnes CLK, Timmers PRHJ, Shen X, Gandin I, McDaid AF, Hansen TF, Gordon SD, Giulianini F, Boutin TS, Abdellaoui A, Zhao W, Medina-Gomez C, Bartz TM, Trompet S, Lange LA, Raffield L, van der Spek A, Galesloot TE, Proitsi P, Yanek LR, Bielak LF, Payton A, Murgia F, Concas MP, Biino G, Tajuddin SM, Seppälä I, Amin N, Boerwinkle E, Børglum AD, Campbell A, Demerath EW, Demuth I, Faul JD, Ford I, Gialluisi A, Gögele M, Graff M, Hingorani A, Hottenga JJ, Hougaard DM, Hurme MA, Ikram MA, Jylhä M, Kuh D, Ligthart L, Lill CM, Lindenberger U, Lumley T, Mägi R, Marques-Vidal P, Medland SE, Milani L, Nagy R, Ollier WER, Peyser PA, Pramstaller PP, Ridker PM, Rivadeneira F, Ruggiero D, Saba Y, Schmidt R, Schmidt H, Slagboom PE, Smith BH, Smith JA, Sotoodehnia N, Steinhagen-Thiessen E, van Rooij FJA, Verbeek AL, Vermeulen SH, Vollenweider P, Wang Y, Werge T, Whitfield JB, Zonderman AB, Lehtimäki T, Evans MK, Pirastu M, Fuchsberger C, Bertram L, Pendleton N, Kardia SLR, Ciullo M, Becker DM, Wong A, Psaty BM, van Duijn CM, Wilson JG, Jukema JW, Kiemeney L, Uitterlinden AG, Franceschini N, North KE, Weir DR, Metspalu A, Boomsma DI, Hayward C, Chasman D, Martin NG, Sattar N, Campbell H, Esko T, Kutalik Z, Wilson JF (2017): Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. Nature Communications, 8, 910; doi: 10.1038/s41467-017-00934-5. DOWNLOAD Shen X, Klarić L, Sharapov S, Mangino M, Ning Z, Wu D, Trbojević-Akmačić I, Pučić-Baković M, Rudan I, Polašek O, Hayward C, Spector TD, Wilson JF, Lauc G, Aulchenko YS (2017): Multivariate discovery and replication of five novel loci associated with Immunoglobulin G N-glycosylation. Nature Communications, 8, 447; doi: 10.1038/s41467-017-00453-3. DOWNLOAD Wang B, Li Z, Xu W, Feng X, Wan Q, Zan Y, Sheng S, Shen X (2017): Bivariate genomic analysis identifies a hidden locus associated with bacteria hypersensitive response in Arabidopsis thaliana. Scientific Reports, 7, 45281; doi: 10.1038/srep45281. DOWNLOAD