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一九八六年至一九八九年,中山大学生物系动物学博士研究生,获理学博士学位。论文题目:非洲锥虫动基体DNA功能的研究。 一九七九年至一九 八二年,中山大学生物系硕士研究生,获理学硕士学位。论文题目:中国马、牛伊氏锥虫株的流行病学研究。 一九七七年至一九七九年,中山大学生物系动物学本科(因提前考入研究生,未获学士学位

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寄生原生动物分子生物学

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Li ZF, Guo Q, Zheng L, Ji Y, Xie YT, Lai DH, Lun ZR, Suo X, Gao N. 2017. Cryo-EM structures of the 80S ribosomes from human parasites Trichomonas vaginalis and Toxoplasma gondii. Cell Res. 2017 Aug 15. doi: 10.1038/cr.2017.104. [Epub ahead of print] Gao JM, Xie YT, Xu ZS, Chen H, Hide G, Yang TB, Shen JL, Lai DH, Lun ZR. 2017. Genetic analyses of Chinese isolates of Toxoplasma gondii reveal a new genotype with high virulence to murine hosts. Vet Parasitol. 241:52-60. doi: 10.1016/j.vetpar.2017.05.007. Wang J, Xu C, Lun ZR, Meshnick SR. 2017. Unpacking 'Artemisinin Resistance'. Trends Pharmacol Sci. 38(6):506-511. Review. Li FJ, Xu ZS, Aye HM, Brasseur A, Lun ZR, Tan KSW, He CY. 2017. An efficient Cumate-inducible system for procyclic and bloodstream form Trypanosoma brucei. Mol Biochem Parasitol. 214:101-104. Li FJ, Wang JG, Xu ZS, Soo ADS, Lim TW, Lun ZR, Lin QS, He CY. 2017.ATP production drives autophagy induction in an early-branching eukaryotic parasite. Autophagy, 13(4):715-729. Hong XK, Zhang X, Fusco OA, Lan YG, Lun ZR, Lai DH. 2017. PCR-based identification of Trypanosoma lewisi and Trypanosoma musculi using maxicircle kinetoplast DNA. Acta Trop. 171:207-212. Xie YT, Gao JM, Wu YP, Tang P, Hide G, Lai DH, Lun ZR. 2017. Recombinant α-actinin subunit antigens of Trichomonas vaginalis as potential vaccine candidates in protecting against trichomoniasis. Parasit Vectors. 10(1):83. doi: 10.1186/s13071-017-2009-8. Zheng LL, Deng KW, Deng AC, Wu J, Yang JH, Lun ZR, Qu LH. 2017. Exo-miRExplorer: A comprehensive resource for exploring and comparatively analyzing exogenous microRNAs. Front Microbiol. 8:126. doi: 10.3389/fmicb.2017.00126. eCollection 2017 Li K, Zhou S, Guo Q, Chen X, Lai DH, Lun ZR, Guo X. 2017. The eIF3 complex of Trypanosoma brucei: composition conservation does not imply the conservation of structural assembly and subunits function. RNA. 23(3):333-345. doi: 10.1261/rna.058651.116. Epub 2016 Dec 8. Namayanja M, Dai Y, Nerima B, Matovu E, Lun ZR, Lubega GW, Chen ZJ. 2017. Trypanosoma brucei brucei traverses different biological barriers differently and may modify the host plasma membrane in the process. Exp Parasitol. 174:31-41. Qin AP, Lai DH, Liu QF, Huang WJ, Wu YP, Chen XY, Yan SX, Xia HM, Hide G, Lun ZR, Ayala FJ, and Xiang AP. 2017. Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against Toxoplasma gondii. Proc Natl Acad Sci USA, 114(6):1365-1370. Wen YZ, Su BX, Lyu SS, Hide G, Lun ZR, Lai DH. 2016. Trehalose, an easy, safe and efficient cryoprotectant for the parasitic protozoan Trypanosoma brucei. Acta Trop. 164:297-302. doi: 10.1016/j.actatropica.2016.09.024. Zhou Q, Gu JH, Lun ZR, Ayala FJ and Li ZY. 2016. Two distinct cytokinesis pathways drive trypanosome cell division in opposite directions. Proc Natl Acad Sci USA., 113:2387-2392. Chang KP, Kolli BK; New Light Group. 2016. New "light" for one-world approach toward safe and effective control of animal diseases and insect vectors from leishmaniac perspectives. Parasite & Vectors. 2016; 9(1):396. doi: 10.1186/s13071-016-1674-3. Review. Wen YZ, Lun ZR, Zhu XQ, Hide G, Lai DH. 2016. Further evidence from SSCP and ITS DNA sequencing support Trypanosoma evansi and Trypanosoma equiperdum as subspecies or even strains of Trypanosoma brucei. Infect Genet Evol. 41:56-62. LinRH, Lai DH, Zheng LL, Wu J, Lukeš J, Hide G, Lun Z.R.2015. Analysis of the mitochondrial maxicircle of Trypanosoma lewisi, a neglected human pathogen. Parasites & Vectors. 8:665. DOI 10.1186/s13071-015-1281-8. Lun ZR, Wu MS, Chen YF, Wang JY, Zhou XN, Liao LF, Chen JP, Chow MC, KP Chang. 2015. Visceral leishmaniasis in China: An endemic disease under control. Clinical Microbiology Reviews, 28:987-1004. Guo HM, Gao JM, Luo YL, Wen YZ, Zhang YL, Hide G, Zhou WL, Ayala FJ, Lun ZR. 2015. Infection by Toxoplasma gondii, a severe parasite in neonates and AIDS patients, causes impaired anion secretion in airway epithelia. Proc. Natl. Acad. Sci. USA, 112: 4435-4440. Lun ZR, Lai, DH, Wen YZ, Zheng LL, Sheng JL, Yang TB, Zhou WL, Hide G, Qu LH, Ayala FJ. (2015). Cancer in the parasitic protozoans Trypanosoma brucei and Toxoplasma gondii. Proc. Natl. Acad. Sci. USA. 112:8835-8842. Lun ZR, Wen YZ, Uzureau P, Lecordier L, Lai DH, Lan YG, Desquesnes M, Geng GQ, Yang TB, Zhou WL, Jannin JG, Simarro PP, Truc P, Vincendeau P, Pays E. 2015. Resistance to normal human serum reveals Trypanosoma lewisi as an underestimated human pathogen. Mol Biochem Parasitol., 199:58-61. Carnes J, Anupama A, Balmer O, Jackson A, Lewis M, Brown R, Cestari I, Desquesnes M, Gendrin C, Hertz-Fowler C, Imamura H, Ivens A, Kořený L, Lai DH, MacLeod A, McDermott SM, Merritt C, Monnerat S, Moon W, Myler P, Phan I, Ramasamy G, Sivam D, Lun ZR, Lukeš J, Stuart K, Schnaufer A. (2015). Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty. PLoS Negl. Trop. Dis. 9 (1):e3404. Xie YT, Lai DH, Liu GY, Zhou JL, Lun ZR. 2015. Severe fever with thrombocytopenia syndrome in China. The Lancet Inf. Dis. 15(2):145. Gao JM, Yi SQ, Wu MS, Geng GQ, Shen JL, Lu FL, Hide G, Lai DH, Lun ZR. 2015. Investigation of infectivity of neonates and adults from different rat strains to Toxoplasma gondii Prugniaud shows both variation which correlates with iNOS and Arginase-1 activity and increased susceptibility of neonates to infection. Exp. Parasitol. 149:47-53.

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