Weaver, Jimmie - Oklahoma State University

个人简介

Jimmie D. Weaver was born and raised here in Oklahoma. He completed B.S. in Chemistry with math and physics minors in 2004 from Southern Nazarene University where he was a defensive lineman on the football team during the teams early years. He spent the next year working in an immunology lab under the guidance of Prof. William Hildebrand, OUHSC where he learned many of the techniques used in biology, cell culture, ELISA assays, affinity chromatography, etc. After a year, Jimmie joined the graduate program at The University of Kansas where he worked with Prof. Jon Tunge. From 2005-2010 Jimmie developed Pd-mediated decarboxylative coupling reactions. After completion of his PhD, Jimmie took a post-doc position with Jon Ellman at Yale University in 2010, where he focused on catalyst development for asymmetric sulfinyl-urea catalyzed reactions. In the fall of 2012, Jimmie took an assistant professor position at Oklahoma State University where he has established an independent research program focused on the catalytic generation and exploitation of reactive intermediates for really cool applications such as C-H functionalization (mostly geared towards SAR studies), C-F functionalization and cross-coupling of perfluoroarenes, uphill catalysis, and environmental remediation of persistent organic pollutants.

研究领域

The Weaver group attempts to ask fundamentally interesting questions, understanding of which allows us to push the boundaries of what is possible. We are particularly interested in developing strategies that allow the catalytic generation of reactive interemediates as well as the behavior of these transient species. What we have learned has implications to several areas of broad interest including cross-coupling reactions, C-F functionalization chemistry, and even performing catalysis in a endergonic direction i.e. uphill catalysis. Out of our fundamental interest has grown a number of other interests which we pursue as a natural consequence of where the chemistry leads us.

近期论文

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Manjula D. Rathnayake, Jimmie D. Weaver, III*. "A General Photocatalytic Route to Prenylation"A General Photocatalytic Route to Prenylation" Eur. J. Org. Chem.. 2019, Accepted Author Manuscript. doi:10.1002/ejoc.201900356 Daniel Jespersen, Brockton Keen, Jon I. Day, Anuradha Singh, Justin Briles, Duncan Mullins, and Jimmie D. Weaver, III*. "Solubility of Iridium and Ruthenium Organometallic Photoredox Catalysts" Org. Process Res. Dev., 2019, Article ASAP DOI: 10.1021/acs.oprd.9b00041. Sonal Priya, Jimmie D. Weaver, III. "Prenyl Praxis: A Method for Direct Photocatalytic Defluoroprenylation" J. Am. Chem. Soc., 2018, 140 (47), 16020. Kip Teegardin, Lacey Gotcher, Jimmie D. Weaver, III. "Formation of Non-Natural α,α-Disubstituted Amino Esters via Catalytic Michael Addition" Org. Lett., 2018, 20 (22), 7239. Jon I. Day, Kamaljeet Singh, Winston Trinh, and Jimmie D. Weaver, III, "Visible light mediated generation of trans-arylcyclohexenes and their utilization in the synthesis of cyclic bridged ethers" J. Am. Chem. Soc., 2018, 140, 9934. This article was featured as a JACS cover: Kamaljeet Singh, Winston Trinh and Jimmie D. Weaver, III, "An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings" Org. Biomol. Chem., 2018, Advance Article DOI: 110.1039/C8OB01273C Publication Date (Web): June 25, 2018 This article was featured as a highlight for the RSC blog by blogger Dr. Victoria Corless. Carla Saunders, Mohammed B. Khaled, Jimmie D. Weaver, and Dean J Tantillo, "Prediction of 19F NMR Chemical Shifts for Fluorinated Aromatic Compounds" J. Org. Chem., 2018, 83, 3220. Kip A. Teegardin and Jimmie D. Weaver, "Preparation of Fac-Tris(2-Phenylpyridinato) Iridium(III)" Org. Synth. 2018, 95, 29. Kamaljeet Singh, Christopher J. Fennell, Evangelos A. Coutsias, Reza Latifi, Steve Hartson, Jimmie D. Weaver, "Light Harvesting for Rapid and Selective Reactions: Click Chemistry with Strain-Loadable Alkenes" Chem, 2018, 4 (1), 124. Mohammad B. Khaled, Roukaya K El Mokadem, and Jimmie D. Weaver "Hydrogen Bond Directed Photocatalytic Hydrodefluorination; Overcoming Electronic Control" J. Am. Chem. Soc., 2017, 139, 13092. Sameera Senaweera and Jimmie D. Weaver "SNAr catalysis enhanced by an aromatic donor–acceptor interaction; facile access to chlorinated polyfluoroarenes" Chem. Commun., 2017, 53, 7545. Jon I. Day and Jimmie D. Weaver * "Selective and Scalable Perfluoroarylation of Nitroalkanes" J. Org. Chem., 2017, 82, 6801 Kip A. Teegardin and Jimmie D. Weaver* "Polyfluoroarylation of oxazolones: access to non-natural fluorinated amino acids" Chem. Commun., 2017, 53, 4771 Sameera Senaweera and Jimmie D. Weaver* "Photocatalytic C-F Reduction and Functionalization" Aldrichimica Acta, 2016, 49, 45. Amandeep Arora and Jimmie D. Weaver* "Visible Light Photocatalysis for the Generation and Use of Reactive Azolyl and Polyfluoroaryl Intermediates" Acc. Chem. Res., 2016, 49, 2273. Arora, A.; Weaver, J. D., "Photocatalytic Generation of 2-Azoyl Radicals; Intermediates for the Azoylation of Arenes and Heteroarenes via C-H Functionalization" Org. Lett., 2016, 18, 3996. A. Singh, C. J. Fennell and J. D. Weaver, "Photocatalyst size controls electron and energy transfer: selectable E/Z isomer synthesis via C–F alkenylation" Chem. Sci., 2016, 7, 6796. Teegardin, K.; Day, J. I.; Chan, J.; Weaver, J. "Advances in Photocatalysis: A Microreview of Visible Light Mediated Ruthenium and Iridium Catalyzed Organic Transformations" Org. Process Res. Dev., 2016, 20, 1156. Sameera Senaweera and Jimmie D. Weaver, "Dual C–F, C–H Functionalization via Photocatalysis: Access to Multifluorinated Biaryls" J. Am. Chem. Soc., 2016, 138, 2520. This paper was highlighted in C&En News,http://cen.acs.org/articles/94/i10/Dual-CFCH-functionalization-unveiled.html A. Singh, J. J. Kubik and J. D. Weaver, "Photocatalytic C–F alkylation; facile access to multifluorinated arenes" Chem. Sci., 2015, 6, 7206.