个人简介
教育经历
1982.9~1986.7 华南理工大学微生物工程本科，工学学士
1986.9～1989.7 华南理工大学工业发酵硕士，工学硕士
1998.7～2001.7 中山大学博士，理学博士
研究领域
微生物代谢工程与合成生物学 主要从事萜类、酪氨酸衍生物及其生物碱等天然产物的微生物代谢工程与合成生物学的研究。研究兴趣主要集中在利用代谢工程、合成生物学及系统生物学相结合的技术，包括启动子工程、染色体工程、转录机制工程、基因组编辑、进化工程、微生物传感器工程、基于组学的系统代谢工程、CRISPR工程等，对微生物细胞进行全局调控，构建高效细胞工厂(大肠杆菌、酿酒酵母和谷氨酸棒杆菌)，以过量生产萜类(番茄红素、玉米黄素、虾青素和航空燃油)、酪氨酸衍生物及其生物碱(莽草酸、对羟基苯乙酸、L-DOPA、白藜芦醇、吗啡和黄连素)等高附加值的天然产物。
近期论文
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Lu A, Liu JZ*: Enhanced Astaxanthin Production in Escherichia coli via Morphology and Oxidative Stress Engineering. Journal of Agricultural and Food Chemistry 2019, 67:11703-11709.(2019.10)
Shen YP, Fong LS, Yan ZB, Liu JZ*: Combining directed evolution of pathway enzymes and dynamic pathway regulation using a quorum‑sensing circuit to improve the production of 4‑hydroxyphenylacetic acid in Escherichia coli. Biotechnology for Biofuels 2019, 12:94. (2019.4)
Niu FX, He X, Wu YQ, Liu JZ*: Enhancing production of pinene in Escherichia coli by using a combination of tolerance, evolution, and modular co-culture engineering. Frontiers in Microbiology 2018, 9: 1623 (2018.7).
Li Z, Shen YP, Jiang XL, Feng LS, Liu JZ*: Metabolic evolution and a comparative omics analysis of Corynebacterium glutamicum for putrescine production.Journal of Industrial Microbiology & Biotechnology 2018, 45:123-139. (2018.2)
Li Z, Liu JZ*: Transcriptomic changes in response to putrescine production in metabolically engineered Corynebacterium glutamicum. Frontiers in Microbiology 2017, 8: 1987. (2017.10)
Lu Q, Bu YF, Liu JZ*: Metabolic engineering of Escherichia coli for producing astaxanthin as the predominant carotenoid.Marine Drugs 2017, 15: 296. (2017.10)
Niu FX, Lu Q, Bu YF, Liu JZ*: Metabolic engineering for the microbial production of isoprenoids: Carotenoids and isoprenoid-based biofuels.Synthetic and Systems Biotechnology 2017, 2:167-175. (2017.9)
Shen HJ, Cheng BY, Zhang YM, Tang L, Li Z, Bu YF, Li XR, Tian GQ, Liu JZ*: Dynamic control of the mevalonate pathway expression for improved zeaxanthin production in Escherichia coli and comparative proteome analysis.Metabolic Engineering 2016, 38:180-190. (2016.11)
Wei T, Cheng BY, Liu JZ*: Genome engineering Escherichia coli for L-DOPA overproduction from glucose.Scientific Reports 2016,6: 30080. (2016.7.15)
Huang KY, Hu HY, Tang YL, Xia FG, Luo XQ, Liu JZ*: High-level expression, purification and large-scale production of l-methionine gamma-lyase from Idiomarina as a novel anti-leukemic drug.Marine Drugs 2015, 13:5492-5507. (2015.8)
Shen HJ, Hu JJ, Li XR, Liu JZ*: Engineering of Escherichia coli for lycopene production through promoter engineering.Current Pharmaceutical Biotechnology 2015, 16:1094-1103.
Zhang YY, Bu YF, Liu JZ*: Production of L-ornithine from sucrose and molasses by recombinant Corynebacterium glutamicum. Folia Microbiologica 2015, 60:393-398. (2015.9)
Li XR, Tian GQ, Shen HJ, Liu JZ*: Metabolic engineering of Escherichia coli to produce zeaxanthin.Journal of Industrial Microbiology & Biotechnology 2015, 42:627-636. (2015.4)
Huang MT, Chen YY, Liu JZ*: Chromosomal engineering of Escherichia coli for efficient production of Coenzyme Q(10).Chinese Journal of Chemical Engineering 2014, 22:559-569. (2014.5)
Cui YY, Ling C, Zhang YY, Huang J, Liu JZ*: Production of shikimic acid from Escherichia coli through chemically inducible chromosomal evolution and cofactor metabolic engineering.Microbial Cell Factories 2014, 13: 21. (2014.2.10)
Jiang LY, Zhang YY, Li Z, Liu JZ:* Metabolic engineering of Corynebacterium glutamicum for increasing the production of L-ornithine by increasing NADPH availability.Journal of Industrial Microbiology & Biotechnology 2013, 40:1143-1151. (2013.10)
Jiang LY, Chen SG, Zhang YY, Liu JZ*: Metabolic evolution of Corynebacterium glutamicum for increased production of L-ornithine.Bmc Biotechnology 2013, 13: 47 (2013. 6.1)
Chen YY, Shen HJ, Cui YY, Chen SG, Weng ZM, Zhao M, Liu JZ*: Chromosomal evolution of Escherichia coli for the efficient production of lycopene.BMC Biotechnology 2013, 13:6 (2013.1.28)
Lu DM, Liu JZ*, Mao ZW: Engineering of Corynebacterium glutamicum to enhance l-ornithine production by gene knockout and comparative proteomic analysis. Chinese Journal of Chemical Engineering 2012,20:731-739. (2012.8)
Lu DM, Jiang LY, Chen LA, Liu JZ*, Mao ZW: Optimization of fermentation conditions of the engineered Corynebacterium glutamicum to enhance L-ornithine production by response surface methodology. Journal of Biotechnology & Biomaterials, 2011, 1:116. doi:10.4172/2155-952X.1000116
Huang MT, Wang Y, Liu JZ*, Mao ZW: Multiple strategies for metabolic engineering of Escherichia coli for efficient production of Coenzyme Q(10).Chinese Journal of Chemical Engineering 2011,19:316-326. (2011.4)
Zhang Y, Liu JZ*, Huang JS, Mao ZW: Genome shuffling of Propionibacterium shermanii for improving vitamin B12 production and comparative proteome analysis.Journal of Biotechnology 2010, 148:139-143. (2010. 7.20)
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