Chen, Peng - Cornell University - Department of Chemistry and Chemical Biology

个人简介

Professional Appointments 7/2013 - Peter J. W. Debye Professor of Chemistry, Cornell University 1/2013 - Professor of Chemistry and Chemical Biology, Cornell University 2011 - 2012 Associate Professor of Chemistry and Chemical Biology, Cornell University 2005 - 2011 Assistant Professor of Chemistry and Chemical Biology, Cornell University Education and Training 2004 - 2005 Postdoctoral Fellow, Chemistry and Chemical Biology, Harvard University Advisor: Prof. X. Sunney Xie. Field: Single-Molecule Biophysics 1998 - 2003 Ph.D. (Jan 2004), Chemistry, Stanford University Advisor: Prof. Edward I. Solomon. Field: Bioinorganic/Physical Inorganic Chemistry Thesis: "Spectroscopic Definition of Electronic Structure Contributions to O2 and N2O Activation by Mononuclear, Binuclear, and Tetranuclear Copper Sites in Biology" 1997 - 1998 Teaching and Graduate Research Assistant, University of California, San Diego Advisor: Prof. Yitzhak Tor. Field: Organic Chemistry 1993 - 1997 B.S., Chemistry, Nanjing University, China Advisor: Prof. Jianyi Shen. Field: Physical Chemistry Selected Honors and Awards 2018 Sessler Distinguished Alumni Lecturer, Stanford University 2017 Visiting Professor in the Debye Chair, Utrecht University 2017 Catalysis Forum Lecturer, DICP, Chinese Academy of Sciences 2016 Excellence in Catalysis Award, Catalysis Society of Metro NY 2016 NSF Colloquium Lecturer, Tata Institute of Fundamental Research 2014 Finalist, Blavatnik National Awards for Young Scientists 2014 Early-Career Award in Experimental Physical Chemistry, ACS PHYS Division 2014 Coblentz Award 2013 Honorable Lecturer, Applied Chemistry Lecture Series, CIAC, Chinese Academy of Sciences 2013 Lester S. Andrews Lecturer, Mississippi State University 2011 CAPA Distinguished Junior Faculty Award 2010 Paul D. Saltman Memorial Award 2009 Alfred P. Sloan Research Fellow 2007 NSF Career Award 2005 Camille and Henry Dreyfus New Faculty Award 2002 Franklin Veatch Memorial Fellowship 1999 Gerhard Casper Stanford Graduate Fellowship 1996 Guanghua Award 1994 YinSong Award 1993 - 1997 RenMin Award, four times 1993 - 1997 Excellent Student Honor, four times

研究领域

Our research focuses on developing and applying single-molecule techniques to solve scientific problems of physical, bioinorganic, and biophysical in nature. Compared with traditional ensemble measurements, single-molecule approaches remove ensemble averaging, so that transient intermediates and heterogeneous subpopulations can be captured and characterized. Current projects are divided into two main areas: Single-molecule catalysis. Here we study the catalytic, electrocatalytic, and photoelectrocatalytic properties of nanoscale materials and small-molecule catalysts at the single-turnover temporal resolution and nanometer spatial resolution. The goal here is to acquire chemical knowledge for developing better catalysts for chemical processing, fuel generation, and (solar) energy conversion. Single-molecule bioinorganic/biophysical chemistry. Here we study the dynamics and mechanisms of the protein machineries involved in cellular metal regulation, trafficking, and efflux both in vitro and in living cells, as well as of molecular processes related to protein folding in living cells. The goal here is to acquire chemical and biological knowledge for developing strategies to cure and prevent diseases.

近期论文

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N. Zou, X. Zhou, G. Chen, N. M. Andoy, W. Jung, G. Liu, P. Chen* "Cooperative communication within and between single nanocatalysts" Nature Chem. 2018, 10, 607-614. G. Chen, N. Zou, B. Chen, J. B. Sambur, E. Choudhary, P. Chen* "Bimetallic effect of single nanocatalysts visualized by super-resolution catalysis imaging" ACS Cent. Sci. 2017, 3, 1189-1197. C. Liu, K. Kubo, E. Wang, K.-S. Han, F. Yang, G. Chen, F. A. Escobedo,* G. W. Coates,* P. Chen* "Single polymer growth dynamics" Science 2017, 358, 353-355. A. G. Santiago, T.-Y. Chen, L. A. Genova, W. Jung, A. M. G. Thompson, M. M. McEvoy, P. Chen* “Adaptor protein mediates dynamic pump assembly for bacterial metal efflux” Proc. Natl. Acad. Sci. U.S.A. 2017, 114, 6694-6699. J. B. Sambur, T.-Y. Chen, E. Choudhary, G. Chen, E. J. Nissen, E. M. Thomas, N. Zou, P. Chen* "Sub-particle reaction and photocurrent mapping to optimize catalyst-modified photoanodes" Nature 2016, 530, 77-80. D. J. Martell, C. P. Joshi, A. Gaballa, A. G. Santiago, T.-Y. Chen, W. Jung, J. D. Helmann, P. Chen* “Metalloregulator CueR biases RNA polymerase’s kinetic sampling of dead-end or open complex to repress or activate transcription” Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 13467-13472. T.-Y. Chen, A. G. Santiago, W. Jung, L. Krzeminski, F. Yang, D. J. Martell, J. D. Helmann, P. Chen* “Concentration and chromosome-organization dependent regulator unbinding from DNA for transcription regulation in living cells” Nature Commun. 2015, 6, 7445. DOI: 10.1038/ncomms8445. N. M. Andoy, X. Zhou, E. Choudary, H. Shen, P. Chen* "Single-Molecule Catalysis Mapping Quantifies Site-specific Activity and Uncovers Radial Activity Gradient on Single 2D Nanocrystals" J. Am. Chem. Soc. 2013, 135, 1845-1852. C. P. Joshi,D. Panda,D. J. Martell,N. M. Andoy, T.-Y. Chen, A. Gaballa, J. D. Helmann, P. Chen* "Direct Substitution and Assisted Dissociation Pathways for Turning Off Transcription by A MerR-family Metalloregulator" Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 15121-15126. X. Zhou, N. M. Andoy, G. Liu, E. Choudhary, K.-S. Han, H. Shen, P. Chen* "Quantitative Super-resolution Imaging Uncovers Reactivity Patterns on Single Nanocatalysts" Nature Nanotech. 2012, 7, 237–241. W. Xu, J. S. Kong, Y.-T. E. Yeh, P. Chen* "Single-Molecule Nanocatalysis Reveals Heterogeneous Reaction Pathways and Catalytic Dynamics" Nature Mater. 2008, 7, 992-996.